Funded Postdoctoral Positions

We currently have 2 funded Postdoctoral Research Associate positions available  - Previous applicants need not apply

Research Associate - Chemical biologist (Fixed Term)
Structure and function of G-quadruplex secondary structures in DNA


Fixed-term: The funds for this post are available for 2 years in the first instance.  Applications are invited for a highly motivated postdoctoral scientist to work with Professor Sir Shankar Balasubramanian on a Cancer Research UK funded project to investigate the structure and function of G-quadruplex secondary structures in DNA.  The position is available from August 2018 onwards.  Certain G-rich DNA (and RNA) sequences can fold into four-stranded secondary structures called G-quadruplexes.  We have been studying the formation of these structures in vitro and in cells with a view to elucidating their function(s), their roles in disease states and their potential as molecular targets for drugs.  Evidence suggests G-quadruplexes may be important for the control of transcription, translation and other key processes in biology.  Our research programme uses a combination of interdisciplinary approaches that include chemical biology, molecular biophysics, structural biology, cell biology and genomics to explore mechanisms involving G-quadruplexes with an emphasis on intervention strategies for cancer [e.g. see Nature Reviews Molecular Cell Biology, 2017, 18, 279; Nature Chemistry, 2017, 9, 1110; Nature Genetics, 2016, 48, 1267-1272; Nature, 2018, 558, 465-469; Nature Communications, 20178, 14432].

We look to appoint a scientist with experience and/or a strong interest in nucleic acids who can develop and apply molecular approaches to elucidate mechanisms.  The successful candidate will possess strong experimental skills in chemical biology and/or molecular biology and demonstrate a rigorous intellectual capacity for innovation and show exceptional initiative and independent thinking.  We seek individuals with excellent communication skills and the ability to work effectively as part of a multidisciplinary team.

Candidates should have (or be about to receive) a PhD in a relevant discipline.  See https://www.balasubramanian.co.uk for further information.

Only candidates who apply through the University's on-line Web Recruitment System will be considered.  See http://www.jobs.cam.ac.uk/job/18249/

For queries regarding applying online for this post, please contact Jo Lockhart, PA to Professor Sir Shankar Balasubramanian, email: herchel-smith-medchem-pa@ch.cam.ac.uk.

Please quote reference MA16241 on your application and in any correspondence about this vacancy.

Research Associate - Chemical Biologist (Fixed Term)
To explore natural, modified bases in DNA and their epigenetic functions


Fixed-term: The funds for this post are available for 2 years in the first instance.We seek a postdoctoral scientist to work with Professor Sir Shankar Balasubramanian on a Wellcome Trust-funded project to investigate nucleic acid base modifications. The position is available from August 2018 onwards.The DNA alphabet also includes natural chemical modifications to DNA bases that can change the structure, recognition and function of DNA. Our programme of research aims to elucidate DNA base modifications and their effects on the folded structure of DNA, protein-DNA interactions and also the assembly of nucleosomes with the goal of explaining how and why this modulates the function of cells and organisms. Examples will include 5-methylcytosine, a well-known epigenetic feature in addition to more recently discovered modified bases such as 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine. Our lab employs and develops chemical, physical, biological and genomic approaches to investigate the presence of, and to gain mechanistic insights into modified base function in human, mouse and parasite genomes [e.g. see: Nature Reviews Chemistry, 2017, 1, 0069; Nature Chemical Biology, 2015, 11, 555; Nature Structural & Molecular Biology, 2015, 22, 44; Nature Chemistry, 2014, 6, 1049; Genome Biology, 2012, 13:R69; Science, 2012, 336, 934].

We look to appoint someone with a strong interest in nucleic acids, who can develop and apply molecular approaches to understand how structure leads to function. The successful candidate is expected to be skilled in analytical methods, organic synthesis and molecular design, and have a capacity for innovation and creativity. Ideally, the candidate will also have an interest or experience in molecular biology and the application of chemistry to cell biology. Strong communication skills and the ability to work effectively as part of a multi-disciplinary team will be important.

Candidates should have (or be about to receive) a PhD in a relevant discipline.  See https://www.balasubramanian.co.uk for further information.

Only applicants using the University's Web Recruitment Systemwide be considered (http://www.jobs.cam.ac.uk/job/18250/)

Please ensure that you upload a 2-page Curriculum Vitae (CV), a covering letter and publications list in the Upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries regarding applying online for this post, please contact Jo Lockhart, PA to Professor Sir Shankar Balasubramanian, email: herchel-smith-medchem-pa@ch.cam.ac.uk.

Please quote reference MA16242 on your application and in any correspondence about this vacancy.