Funded Postdoctoral Positions

Research Associate - Chemist/Chemical Biologist (Fixed Term)

Fixed-term: The funds for this post are available for 2 years in the first instance.

The Balasubramanian group seeks to recruit a postdoctoral chemist to work on an ambitious project aimed at the production of molecularly annotated 3D atlases of tumours, funded by a Cancer Research UK Grand Challenge Award. The post holder will be based at the Department of Chemistry and work in close contact with colleagues in the Imaging and Molecular Annotation of Xenografts (IMAXT) team at the CRUK Cambridge Institute (see https://imaxt.cruk.cam.ac.uk).

The successful applicant will play a key role in developing new technologies and chemical tools to produce bioconjugates of antibodies, small molecules and/or oligonucleotides and use them as probes to measure the genetic and proteomic landscape of cancer in situ. The post holder will also contribute to the development of new strategies to specifically crosslink nucleic acids from biological samples to various polymer matrices and hydrogels to enable improved imaging, and to achieve chemical ligation of oligonucleotides on solid supports, ideally in an inducible manner.

The successful applicant will have a strong background in organic chemistry and chemical biology, with an interest in bioconjugation, nucleic acid and/or peptide chemistry. Some experience or interest in molecular and cellular biology would be desirable. We seek a highly-motivated individual with excellent communication skills and who is able to work effectively as part of a multi-disciplinary team. The candidate should possess strong laboratory skills, show exceptional initiative and demonstrate a capacity for innovation and independent thought.

Candidates should have (or be about to receive) a PhD in a relevant discipline.

Only candidates who apply through the University online recruitment system will be considered.  Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.  Apply online

For queries relating to your application or the application process, please contact Jo Lockhart, PA to Professor Sir Shankar Balasubramanian (BalasubramanianRecruitment@ch.cam.ac.uk) or Ilaria Falciatori, IMAXT Project Manager (Ilaria.Falciatori@cruk.cam.ac.uk).

Please quote reference MA21104 on your application and in any correspondence about this vacancy.

Research Associate - The Chemical Biology of DNA (Fixed Term)

Fixed-term: The funds for this post are available for 2 years in the first instance.

The Balasubramanian group seeks a postdoctoral chemical biologist to investigate the role of G-quadruplex DNA secondary structures and natural chemical modifications to DNA bases. In particular, the successful applicant will play a key role in developing novel epigenetic and DNA structure engineering technologies to explore how the chemistry and structure of nucleic acids structure influences oncogenesis.

The candidate will have a strong background in organic chemistry as applied to nucleic acids and in the use of chemical biology with genome editing methods in cells. We are particularly interested in applicants who have proven experience in the use of chemical approaches for sequence-specific DNA targeting to manipulate gene expression. We seek a highly-motivated individual with excellent communication skills and who is able to work effectively as part of a multi-disciplinary team. The candidate should possess strong laboratory skills, show exceptional initiative and demonstrate a capacity for innovation and independent thought.

Candidates should have (or be about to receive) a PhD in a relevant discipline.

Only candidates who apply through the University online recruitment system will be considered.  Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.  Apply online

For queries relating to your application or the application process, please contact Jo Lockhart, PA to Professor Sir Shankar Balasubramanian (BalasubramanianRecruitment@ch.cam.ac.uk).

Please quote reference MA21413 on your application and in any correspondence about this vacancy.