Funded Postdoctoral Positions

We are seeking Postdoctoral Research Associates to work on our Wellcome Trust and CRUK grants.

Previous applicants need not apply

Molecular biologists/biochemists to explore DNA base modifications and their epigenetic functions


Fixed term: The funds for this post are available for 2 years in the first instance.  This position is available from November 2018 onwards.

We seek postdoctoral scientists to work with Professor Sir Shankar Balasubramanian on a Wellcome Trust-funded programme to investigate the epigenetic role of nucleic acid base modifications. This is an interdisciplinary project that encompasses organic and biophysical chemistry, chemical and molecular biology and genomics.  See https://www.balasubramanian.co.uk for further information.

We look to appoint outstanding molecular biologists or biochemists to carry out research on how chemically modified bases affect the structure and function of DNA. Part of the investigations will involve a consideration of the chemistry and enzymology of nucleic acids, protein-DNA interactions, chromatin structure and transcription. This will enable us to gain a deeper understanding of epigenetic regulation in normal and disease states using human, mouse and parasite systems along with experimental developmental model systems.

The successful candidate will have a capacity for innovation and creativity. Strong communication skills and the ability to work effectively as part of a multi-disciplinary team will be important. Experience in working in an interdisciplinary environment, particularly with chemists/chemical biologists would be an advantage.

Candidates should have (or be about to receive) a PhD in a relevant discipline.

Only candidates who apply through the University's on-line Web Recruitment System will be considered.  Further details can be found at http://www.jobs.cam.ac.uk/job/19081/. Please ensure that you upload a 2-page Curriculum Vitae (CV), a covering letter and publications list in the Upload section of the online application. Previous applicants need not apply.

Closing date: 5th November 2018

For queries regarding this post quoting reference MA16983, please contact Jo Lockhart, PA to Professor Sir Shankar Balasubramanian, email: BalasubramanianRecruitment@ch.cam.ac.uk

Chemists/Chemical biologists to study DNA base modifications and their epigenetic functions


Fixed term: The funds for this post are available for 2 years in the first instance. This position is available from November 2018 onwards.

We seek postdoctoral scientists to work with Professor Sir Shankar Balasubramanian on a Wellcome Trust-funded programme to investigate the epigenetic role of chemically modified nucleic acid bases. This is an interdisciplinary project that encompasses organic and biophysical chemistry, chemical and molecular biology and genomics.  See https://www.balasubramanian.co.uk for further information.

We look to appoint chemists or chemical biologists to carry out research on how chemically modified bases affect the structure and function of DNA.  Part of the investigations will involve a consideration of the chemistry and enzymology of nucleic acids, protein-DNA interactions, chromatin structure and transcription. This will enable us to gain a deeper understanding of epigenetic regulation in normal and disease states using human, mouse and parasite models.

The successful candidate will have a capacity for innovation and creativity. Strong communication skills and the ability to work effectively as part of a multi-disciplinary team will be important. Experience in nucleic acid chemistry and working in an interdisciplinary environment with molecular/cell biologists or biochemists would be an advantage.

Candidates should have (or be about to receive) a PhD in a relevant discipline.

Only candidates who apply through the University's on-line Web Recruitment System will be considered.  Please see further details http://www.jobs.cam.ac.uk/job/19079/. Please ensure that you upload a 2-page Curriculum Vitae (CV), a covering letter and publications list in the Upload section of the online application. Previous applicants need not apply.

Closing date: 5th November 2018

For queries regarding this post quoting reference MA16981, please contact Jo Lockhart, PA to Professor Sir Shankar Balasubramanian, email: BalasubramanianRecruitment@ch.cam.ac.uk

Chemical biologist – Structure and function of G-quadruplex secondary structures in DNA


Fixed term: The funds for this post are available for 2 years in the first instance.  The position is available from November 2018 onwards.

Applications are invited for a postdoctoral scientist to work with Professor Sir Shankar Balasubramanian on a Cancer Research UK funded project.

Certain G-rich DNA (and RNA) sequences can fold into four-stranded secondary structures called G-quadruplexes.  We have been studying the formation of these structures in vitro and in cells to understand their function(s), their roles in mechanisms of importance to cancer and their potential as molecular targets for drugs. We are particularly interested in why G-quadruplexes form and how they affect the processes of transcription, translation.  Part of this work will involve the study of protein-G-quadruplex interactions. Our research programme uses a combination of interdisciplinary approaches that include chemical biology, molecular biophysics, structural biology, cell biology and genomics to explore mechanisms involving G-quadruplexes with an emphasis on intervention strategies for cancer [e.g. see Nature Reviews Molecular Cell Biology2017, 18, 279; Nature Chemistry2017,9, 1110; Nature Genetics, 2016,48, 1267-1272; Nature2018,558, 465–469; Nature Communications20178, 14432].

We look to appoint a scientist with experience with an interest in nucleic acids who can develop and apply molecular approaches to elucidate mechanisms. Skills in chemical biology are essential and a knowledge of molecular biology would be beneficial.  We value innovation, initiative and independent thinking. We seek individuals with excellent communication skills and the ability to work effectively as part of a multidisciplinary team.

Candidates should have (or be about to receive) a PhD in a relevant discipline.  See https://www.balasubramanian.co.uk for further information.

Only candidates who apply through the University's on-line Web Recruitment System will be considered.  Further details can be found at http://www.jobs.cam.ac.uk/job/19080/. Please ensure that you upload a 2-page Curriculum Vitae (CV), a covering letter and publications list in the Upload section of the online application. Previous applicants need not apply.

Closing date: 5th November 2018

For queries regarding this post quoting reference MA16982, please contact Jo Lockhart, PA to Professor Sir Shankar Balasubramanian, email: BalasubramanianRecruitment@ch.cam.ac.uk