Funded Postdoctoral Positions

We currently have 4 positions available

Molecular biologists/biochemists based at CRUK Cambridge Institute

Postdoctoral Research Associate: Molecular biologist/biochemist (Fixed Term)  SW27532

We seek a postdoctoral scientist to work with Professor Sir Shankar Balasubramanian on the chemical biology of nucleic acids and their role in the fundamental mechanisms of cancer. The post will be based in our group at Cancer Research UK’s Cambridge Institute (CI) and involves close collaboration with our group based in the University Chemistry Department.

We have a vacancy for a molecular biologist to contribute to our research on genome structure and function.  Current projects include elucidating four-stranded nucleic acid structures (G-quadruplexes), their interacting proteins, their function and suitability as therapeutic targets and biomarkers of cancer.  We also study the structure and function of chemically modified DNA bases and their epigenetic roles in normal biology and disease. Our interdisciplinary lab innovates and applies methods that include sequencing technologies, genome-targeting and chemical biology.

Our ideal candidate will have a capacity for innovation, initiative and creativity to solve biological problems using molecular and cellular strategies. We value good communication skills and an ability to work well in a multi-disciplinary team. This project provides an opportunity for an outstanding individual to make an inspired contribution to the fundamental understanding of genome function.

Postdoctoral Research Associate: Molecular biologist/biochemist to study DNA base modifications and their epigenetic functions (Fixed Term) SW27533

We seek two postdoctoral scientists to work with Professor Sir Shankar Balasubramanian on a Wellcome Trust-funded programme to investigate the structure and function of chemically modified nucleic acid bases. This is an interdisciplinary project that encompasses the use of organic and biophysical chemistry, chemical biology and molecular biology on DNA and on the genome.

We look to appoint chemists or chemical biologists to carry out research on how chemically modified bases affect the structure and function of DNA. The investigations will involve a consideration of the chemistry and enzymology of nucleic acids, protein-DNA interactions, epigenetics, chromatin structure and transcription. This will enable us to gain a deeper understanding of the function of base modifications and their involvement in regulating gene expression in normal and disease states using cellular models from human, and mouse and also parasite models.

Chemists/chemical biologists based at The Department of Chemistry

Postdoctoral Research Associate: Chemist/chemical biologist (Fixed Term)  MA27501

Applications are invited for a postdoctoral chemist to work with Professor Sir Shankar Balasubramanian on the chemical biology of nucleic acids, funded by Cancer Research UK. The successful applicant will work on an interdisciplinary project to elucidate the function and biological mechanisms of four-stranded DNA G-quadruplexes and to investigate their potential as therapeutic targets and biomarkers of cancer. The development and application of chemical tools will be central to the project.  SeeDOI: 10.1016/j.trechm.2019.07.002, DOI: 10.1038/s41580-020-0236-x for further information.

Applicants must have a background in organic chemistry or chemical biology, with strong interest in DNA-related mechanisms. Experience in biochemistry, nucleic acid-protein interactions and transcriptional control would be highly desirable. We seek a highly motivated individual with good communication skills and a capacity for innovation and creativity, who can work well as part of a multi-disciplinary team.

Postdoctoral Research Associate: Chemists/chemical biologists to study DNA base modifications and their epigenetic functions (Fixed Term) MA27502

We seek a postdoctoral scientist to work with Professor Sir Shankar Balasubramanian on a Wellcome Trust-funded programme to investigate the structure and function of chemically modified nucleic acid bases. This is an interdisciplinary project that encompasses the use of biophysics, chemical biology and molecular biology on DNA and on the genome.  See DOI: 10.1021/jacs.9b01915, DOI: 10.1038/s41570-017-0069 for further information.

We look to appoint a chemist or chemical biologist to explore how chemically modified DNA bases affect the structure and function of DNA.  The research will involve chemistry and enzymology of nucleic acids, protein-DNA interactions, epigenetics, chromatin structure and transcription. We aim to gain a deeper understanding of the function of base modifications and their involvement in regulating gene expression in normal and disease states using cellular models from human, and mouse and also parasite models.

General information:    All positions are fixed-term and the funds are available for 2 years in the first instance.  Successful candidates will have a capacity for innovation and creativity. Strong communication skills and the ability to work effectively as part of a multi-disciplinary team will be important. Experience in working in an interdisciplinary environment, particularly with chemists/chemical biologists would be an advantage. Candidates for all positions should have (or be about to receive) a PhD in a relevant discipline. The positions are available immediately.

We can only accept applications that that come through the University of Cambridge on-line recruitment system via the reference link on each position

For more information about any of these positions, please contact Jo Lockhart, Science Administrator, Balasubramanian Group, quoting the appropriate reference number via email: BalasubramanianRecruitment@ch.cam.ac.uk