DNA molecular motor driven micromechanical cantilever arrays
W Shu, D Liu, M Watari, C K Riener, T Strunz, M E Welland, S Balasubramanian and R McKendry
J. Am. Chem. Soc., 2005, 127, 17054 – 17060
DOI: 10.1021/ja0554514
PNA forms an i-motif
Y Krishnan-Ghosh, E Stephens and S Balasubramanian
Chem. Commun., 2005, 5278 – 5280
DOI: 10.1039/B510405J
Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach
S Ladame, A Whitney and S Balasubramanian
Angew. Chem. Int. Ed., 2005, 44, 5736 – 5739
DOI: 10.1002/anie.200501450
Putative DNA quadruplex formation within the human c-kit oncogene
S Rankin, A P Reszka, J Huppert, M Zloh, G N Parkinson, A K Todd, S Ladame, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 2005, 127, 10584 – 10589
DOI: 10.1021/ja050823u
Dynamic covalent chemistry on self-templating PNA oligomers: formation of a bimolecular PNA quadruplex
Y Krishnan-Ghosh and S Balasubramanian
Chem. Commun., 2005, 3068 – 3070
DOI: 10.1039/B503578C
Prevalence of quadruplexes in the human genome
J L Huppert and S Balasubramanian
Nucleic Acids Res., 2005, 33, 2908 – 2916
DOI: 10.1093/nar/gki609
Solid-phase methods for the synthesis of cyanine dyes
S Mason, J Hake, J Nairne, E J Cummins and S Balasubramanian
J. Org. Chem., 2005, 70, 2939 – 2949
DOI: 10.1021/jo0479415
Loop-length dependent folding of G-quadruplexes
P Hazel, J Huppert, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 2004, 126, 16405 – 16415
DOI: 10.1021/ja045154j
Individual molecules of dye-labeled DNA act as a reversible two-colour switch upon application of an electric field
S S White, L Ying, S Balasubramanian and D Klenerman
Angew. Chem. Int. Ed., 2004, 43, 5926 – 5930
DOI: 10.1021/jp036715g
Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
S D Patel, M Isalan, G Gavory, S Ladame, Y Choo and S Balasubramanian
Biochemistry, 2004, 43, 13452 – 13458
DOI: 10.1021/bi048892t
Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform
S Ladame, J A Schouten, J Stuart, J Roldan, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2004, 2, 2925 – 2931
DOI: 10.1039/B409698C
Measuring Single Molecule Nucleic Acid Dynamics in Solution by Two-Color Filtered Ratiometric Fluorescence Correlation Spectroscopy
H Li, X Ren, S Balasubramanian and D Klenerman
PNAS, 2004, 101, 14425 – 14430
DOI: 10.1073/pnas.0404295101
Formation of an Interlocked Quadruplex Dimer by d(GGGT)
Y Krishnan-Ghosh, D Liu and S Balasubramanian
J. Am. Chem. Soc. , 2004, 125, 11009 – 11016
DOI: 10.1021/ja049259y
Studies on the chemical stability and synthetic utility of an oxazolidine linker for solid-phase chemistry
A J Wills, M Cano and S Balasubramanian
J. Org. Chem., 2004, 69, 5439 – 47
DOI: 10.1021/jo049569z
Molecule by molecule direct and quantitative counting of antibody complexes in solution
H Li, L Ying, S Balasubramanian and D Klenerman
Anal. Chem., 2004, 76, 4446 – 51
DOI: 10.1021/ac049512c
A PNA4 Quadruplex
Y Krishnan-Ghosh, E Stephens and S Balasubramanian
J. Am. Chem. Soc., 2004, 126, 5944 – 5945
DOI: 10.1021/ja031508f
Targeting the Single-Stranded Overhang of Telomeres with PNA Inhibits Cell Growth and Induces Apoptosis of Human Immortal Cells
M A Shammas, X Liu, G Gavory, K D Raney, S Balasubramanian and R J Shmookler Reis
Experimental Cell Research, 2004, 295, 204 – 214
DOI: 10.1016/j.yexcr.2004.01.003
Templated Ligand Assembly using G-quadruplex DNA and Dynamic Covalent Chemistry
A Whitney, S Ladame and S Balasubramanian
Angew. Chem. Int. Ed., 2004, 43, 1143 – 1146
DOI: 10.1002/anie.200353069
Studies on the Structure and Dynamics of the Human Telomeric Quadruplex by Single Molecule Fluorescence Resonance Energy Transfer
L Ying, J J Green, H Li, D Klenerman and S Balasubramanian
PNAS, 2003, 100, 14629 – 14634
DOI: 10.1073/pnas.2433350100
A proton fuelled DNA nanomachine
D Liu and S Balasubramanian
Angew. Chem. Int. Ed., 2003, 42, 5734 – 5736
DOI: 10.1002/anie.200352402
Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenital point mutation
X Ren, G Gavory, H Li, L Ying, D Klenerman and S Balasubramanian
Nucleic Acids Res., 2003, 31, 6509 – 6515
DOI: 10.1093/nar/gkg871
From the combinatorial chemistry boom to polymer-supported parallel chemistry: established technologies for drug discovery
M Cano and S Balasubramanian
Drugs of the Future, 2003, 28, 659 – 678
DOI: 10.1002/chin.200446268
Recent Developments in Linker Design and Application
A J Wills and S Balasubramanian
Curr. Op. Chem. Biol., 2003, 7, 346 – 352
DOI: 10.1016/S1367-5931(03)00035-8
Dynamic Covalent Chemistry on Self-Templating Peptides: Formation of a Disulfide-linked β-Hairpin Mimic
Y Krishnan-Ghosh and S Balasubramanian
Angew. Chem. Int. Ed., 2003, 42, 2171 – 2173
DOI: 10.1002/anie.200250551
G-Quadruplex-Specific Peptide-Hemicyanine Ligands by Partial Combinatorial Selection
J A Schouten, S Ladame, S J Mason, M A Cooper and S Balasubramanian
J. Am. Chem. Soc., 2003, 125, 5594 – 5595
DOI: 10.1021/ja029356w
Kinetics of Unfolding the Human Telomeric DNA Quadruplex using a PNA Trap
J Green, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2003, 125, 3763 – 3767
DOI: 10.1021/ja029149w
Ultrasensitive coincidence fluorescence detection of single DNA molecules
H Li, L Ying, J J Green, S Balasubramanian and D Klenerman
Anal. Chem., 2003, 75, 1664 – 1670
DOI: 10.1021/ac026367z
Site-Specific Cleavage of Human Telomerase RNA using PNA-Neocuproine.Zn(II) derivatives
A Whitney, G Gavory and S Balasubramanian
Chem. Commun., 2003, 36 – 37
DOI: 10.1039/B210135A
PNA and oligonucleoide inhibitors of human telomerase
G Gavory and S Balasubramanian
Telomerases, Telomeres and Cancer Eds., G Krupp and R Parwaresch 67-80, Landes Bioscience: Austin, 2003
Solid phase catch-activate and release synthesis of cyanine dyes
S J Mason and S Balasubramanian
Org. Lett., 2002, 4, 4261 – 62
DOI: 10.1021/ol026836j
Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro
G Gavory, M Farrow and S Balasubramanian
Nucleic Acids Res., 2002, 30, 4470 – 4480
Synthesis of a polymer supported oxazolidine aldehyde for asymmetric chemistry
A J Wills, Y Krishnan-Ghosh and S Balasubramanian
J. Org. Chem., 2002, 67, 6646 – 6652
DOI: 10.1021/jo0203239
Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation
I Horsey, Y Krishnan-Ghosh and S Balasubramanian
Chem. Commun., 2002, 14, 1950 – 51
DOI: 10.1039/B206054J
Solid phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates
S Ladame, R J Harrison, S Neidle and S Balasubramanian
Org. Lett., 2002, 4, 2509 – 2512
DOI: 10.1021/ol026130p
Synthesis of diastereomerically pure 1,4,5-substituted-2-oxopiperazines on solid-phase
N M Khan, M Cano and S Balasubramanian
Tetrahedron Lett., 2002, 43, 2439 – 2443
DOI: 10.1016/S0040-4039(02)00268-X
Practical synthesis of a dithiane protected 3′,5′-dialkyoxybenzoin photolabile safety-catch linker (BPSC) for solid phase organic synthesis
M Cano, M Ladlow and S Balasubramanian
J. Org. Chem., 2002, 67, 129 – 135
DOI: 10.1021/jo010703e
Studies on the chemical stability and functional group compatibility of the Benzoin Photolabile Safety-catch (BPSC) linker using an analytical construct
M Cano, M Ladlow and S Balasubramanian
J. Comb. Chem., 2002, 4, 44 – 48
DOI: 10.1021/cc010040e
Solid Phase Chemical Technologies for Combinatorial Chemistry
S Balasubramanian
J. Cell. Biochem. Suppl., 2001, 37, 28 – 33
Non-Arrhenius kinetics of a DNA Hairpin-Loop
L Ying, M I Wallace, S Balasubramanian and D Klenerman
PNAS, 2001, 98, 5584 – 5589
DOI: 10.1073/pnas.10152349844
Probing DNA surface attachment and local environment using single molecule spectroscopy
M A Osborne, C L Barnes, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2001, 105, 3120 – 3126
DOI: 10.1021/jp0038660
Selection of Zinc Fingers that Bind Single-Stranded Telomeric DNA in the G-Quadruplex Conformation
M Isalan, S D Patel, S Balasubramanian and Y Choo
Biochemistry, 2001, 40, 830 – 836
DOI: 10.1021/bi001728v
Exploring a Benzyloxyaniline Linker Utilizing Ceric Ammonium Nitrate (CAN) as a Cleavage Reagent: Solid-Phase Synthesis of N-Unsubstituted Beta-Lactams and Secondary Amides
K Gordon and S Balasubramanian
Org. Lett., 2001, 3, 53 – 56
DOI: 10.1021/ol006766l
The science of chemical discovery: probing the unknown with new technologies
S Balasubramanian
Drug Discovery Today, 2000, 5, 533-534
DOI: 10.1016/S1359-6446(00)01582-8
FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin Loop
M I Wallace, L Ying, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2000, 104, 11551 – 11555
DOI: 10.1021/jp001560n
A stereoselective synthesis of 1,3,4-substituted -lactams from polymer-supported chiral oxazolidine aldehyde
K Gordon, M Bolger, N Khan and S Balasubramanian
Tetrahedron Lett., 2000, 41, 8621 – 8625
DOI: 10.1021/ol2020048
Strategies for the synthesis of fluorescently labelled PNA
X Liu and S Balasubramanian
Tetrahedron Lett., 2000, 41, 6153 – 6156
DOI: 10.1016/S0040-4039(00)00996-5
Single Molecule Analysis of DNA Immobilised on Microspheres
M A Osborne, W S Furey, D Klenerman and S Balasubramanian
Anal. Chem., 2000, 72, 3678 – 3681
DOI: 10.1021/ac000129r
Ratiometric analysis of single-molecule fluorescence resonance energy transfer using logical combinations of threshold criteria: A study of 12-mer DNA
L Ying, M I Wallace, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2000, 104, 5171 – 5178
DOI: 10.1021/jp993914k
Recent Developments in the Encoding and Deconvolution of Combinatorial Libraries
C L Barnes and S Balasubramanian
Curr. Opin. Chem. Bio., 2000, 4, 346 – 350
DOI: 10.1016/S1367-5931(00)00098-3
Double Fluorescence Resonance Energy Transfer to Explore Multicomponent Binding Interactions: A Case Study of DNA Mismatches
I Horsey, W S Furey, J G Harrison, M A Osborne and S Balasubramanian
Chem. Commun., 2000, 12, 1043 – 1044
DOI: 10.1039/B002540M
Solid-Phase Synthesis of N-Alkyl-N-(β-keto)amides and 1,2,4,5-Tetrasubstituted Imidazoles Using a Traceless Cleavage Strategy
H B Lee and S Balasubramanian
Org. Lett., 2000, 2, 323 – 326
DOI: 10.1021/ol991271l
Read Article