2021 – to date papers


Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity

A Serrano-Benitez, S E Wells, L Drummond-Clarke, L C Russo, J C Thomas, G A Leal, M A Farrow, J M Edgerton, S Balasubramanian, M Yang, C Frezza, A Gautam, J Brazina, K Burdova, N C Hoch, S P Jackson and K W Caldecott
The EMBO Journal., 2023, e113190
DOI: 10.15252/embj.2022223190


A Photoredox Reaction for the Selective Modification of 5-Carboxycytosine in DNA

B J Mortishire-Smith, S M Becker, A Simeone, L Melidis and S Balasubramanian
J. Am. Chem. Soc., 2023, early online article
DOI: 10.1021/jacs.2c12558


Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis

M M Simpson, C C Lam, J M Goodman and S Balasubramanian
Angew. Chemie, 2023, e202304756
DOI: 10.1002/anie.202304756


Simultaneous sequencing of genetic and epigenetic bases in DNA

J Füllgrabe, W S Gosal, P Creed, S Liu, C K Lumby, D J Morley, T W B Ost, A J Vilella, S Yu, H Bignell, P Burns, T Charlesworth, B Fu, H Fordham, N J Harding, O Gandelman, P Golder, C Hodgson, M Li, M Lila, Y Liu, J Mason, J Mellad, J M Monahan, O Nentwich, A Palmer, M Steward, M Taipale, A Vandomme, R S San-Bento, A Singhal, J Vivian, N Wójtowicz, N Williams, N J Walker, N C H Wong, G N Yalloway, J D Holbrook and S Balasubramanian
Nature Biotechnology, 2023, early online article
DOI: 10.1038/s41587-022-01652-0


Chem-map profiles drug binding to chromatin in cells

Z Yu, J Spiegel, L Melidis, W W I Hui, X Zhang, A Radzevičius and S Balasubramanian
Nature Biotechnology, 2023, early online article
DOI: 10.1038/s41587-022-01636-0


Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

I C Navarro, K M Suen, D Bensaddek, A Tanpure, A Lamond, S Balasubramanian and E A Miska
Wellcome Open Res, 2022, 7:282
DOI: 10.12688/wellcomeopenres.17893.1


DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody

S Galli, L Melidis, S M Flynn, D Varshney, A Simeone, J Spiegel, S K Madden, D Tannahill and S Balasubramanian
Journal of the American Chemical Society, 2022, 144, 50, 23096–23103
DOI: 10.1021/jacs.2c10656#


Self-organization of plasticity and specialization in a primitively social insect

S Patalano, A Alsina, C Gregorio-Rodríguez, M Bachman, S Dreier, I Hernando-Herraez, P Nana, S Balasubramanian, S Sumner, W Reik and S Rulands
Cells Systems, 2022, 13:9, 768-700.e4
DOI: 10.1016/j.cels.2022.08.002


Early detection of cancer

D Crosby, S Bhatia, K M Brindle, L M Coussens, C Dive, M Emberton, S Esener, R C Fitzgerald, S S Gambhir, P Kuhn, T R Rebbeck and S Balasubramanian
Science, 2022, 375:6586
DOI: 10.1126/science.aay9040


G-quadruplex DNA structures in human stem cells and differentiation

K G Zyner, A Simeone, S M Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill and S Balasubramanian
Nature Communications, 2022, 13:142
DOI: 10.1038/s41467-021-27719-1


Single-cell mapping of DNA G-quadruplex structures in human cancer cells

W W I Hui, A Simeone, K Zyner, D Tannahill and S Balasubramanian
Scientific Reports, 2021, 11, 23641
DOI: 10.1038/s41598-021-02943-3


RNA G-quadruplex structures control ribosomal protein production

D Varshney, S Martínez Cuesta, B Herdy, U Abdullah, D Tannahill and S Balasubramanian
Scientific Reports, 2021, 11, 22735
DOI: 10.1038/s41598-021-01847-6


Chemical profiling of DNA G-quadruplex-interacting proteins in live cells

X Zhang, J Spiegel, S Martínez Cuesta, S Adhikari and S Balasubramanian
Nature Chemistry, 2021, 13, 626–633
DOI: 10.1038/s41557-021-00736-9


Promoter G-quadruplex folding precedes transcription and is controlled by chromatin

J Shen, D Varshney, A Simeone, X Zhang, S Adhikari, D Tannahill and S Balasubramanian
Genome Biology, 2021, 22, 143
DOI: 10.1186/s13059-021-02346-7


G-quadruplexes are transcription factor binding hubs in human chromatin

J Spiegel, S Martinez Cuesta, S Adhikari, R Hänsel-Hertsch, D Tannahill and S Balasubramanian
Genome Biology, 2021, 22, 117
DOI: 10.1186/s13059-021-02324-z


TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

R Broome, I Chernukhin, S Jamieson, K Kishore, E K Papachristou, S-Q Mao, C Gonzalez Tejedo, A Mahtey, V Theodorou, A J Groen, C D’Santos, S Balasubramanian, A Madalina Farcas, R Siersbæk, J S Carroll
Cell Reports, 2021, 34:8, 108776
DOI: 10.1016/j.celrep.2021.108776