Selective Photocatalytic C-H oxidation of 5-methylcytosine in DNA
T Yan, Y Chen, B Mortishire-Smith, A Simeone, A Hofer and S Balasubramanian
Angew. Chem. Int. Ed., 2024, e202413593
DOI: 10.1002/anie.202413593
Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
S M Flynn, S Dhir, K Herka, C Doyle, L Melidis, A Simeone, W W W Hui, R de Cesaris Araujo Tavares, S Schoenfelder, D Tannahill and S Balasubramanian
Genome Biology., 2024, 25, 237
DOI: 10.1186/s13059-024-03377-6
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
C J Carnie, A C Acampora, A S Bader, C Erdenebat, S Zhao, E Bitensky, D van den Heuvel, A Parnas, V Gupta, G D’Alessandro, M Sczaniecka-Clift, P Weickert, F Aygenli, M J Götz, J Cordes, I Esain-Garcia, L Melidis, A P Wondergem, S Lam, M S Robles, S Balasubramanian, S Adar, M S Luijsterburg, S P Jackson and J Stingele
Nature Cell Biology., 2024, 26, 797-810
DOI: 10.1038/s41556-024-01391-1
An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription
Y Chen, A Simeone, L Melidis, S Martinez Cuesta, D Tannahill and S Balasubramanian
ACS Chem. Biol., 2024, 19, 3, 736-742
DOI: 10.1021/acschembio.3c00775
G-quadruplex DNA structure is a positive regulator of MYC transcription
I Esain-Garcia, A Kirchner, L Melidis, R de Cesaris Araujo Tavares, S Dhir, A Simeone, Z Yu, S K Madden, R Hermann, D Tannahill and S Balasubramanian
PNAS, 2024, 12 (7), e2320240121
DOI: 10.1073/pnas.2320240121
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
A Serrano-Benitez, S E Wells, L Drummond-Clarke, L C Russo, J C Thomas, G A Leal, M A Farrow, J M Edgerton, S Balasubramanian, M Yang, C Frezza, A Gautam, J Brazina, K Burdova, N C Hoch, S P Jackson and K W Caldecott
The EMBO Journal., 2023, e113190
DOI: 10.15252/embj.2022223190
A Photoredox Reaction for the Selective Modification of 5-Carboxycytosine in DNA
B J Mortishire-Smith, S M Becker, A Simeone, L Melidis and S Balasubramanian
J. Am. Chem. Soc., 2023, 145, 19, 10505-105511
DOI: 10.1021/jacs.2c12558
Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis
M M Simpson, C C Lam, J M Goodman and S Balasubramanian
Angew. Chemie, 2023, e202304756
DOI: 10.1002/anie.202304756
Simultaneous sequencing of genetic and epigenetic bases in DNA
J Füllgrabe, W S Gosal, P Creed, S Liu, C K Lumby, D J Morley, T W B Ost, A J Vilella, S Yu, H Bignell, P Burns, T Charlesworth, B Fu, H Fordham, N J Harding, O Gandelman, P Golder, C Hodgson, M Li, M Lila, Y Liu, J Mason, J Mellad, J M Monahan, O Nentwich, A Palmer, M Steward, M Taipale, A Vandomme, R S San-Bento, A Singhal, J Vivian, N Wójtowicz, N Williams, N J Walker, N C H Wong, G N Yalloway, J D Holbrook and S Balasubramanian
Nature Biotechnology, 2023, 41, 1457-1464
DOI: 10.1038/s41587-022-01652-0
Chem-map profiles drug binding to chromatin in cells
Z Yu, J Spiegel, L Melidis, W W I Hui, X Zhang, A Radzevičius and S Balasubramanian
Nature Biotechnology, 2023, 41, 1265-1271
DOI: 10.1038/s41587-022-01636-0
Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA
I C Navarro, K M Suen, D Bensaddek, A Tanpure, A Lamond, S Balasubramanian and E A Miska
Wellcome Open Res, 2022, 7:282
DOI: 10.12688/wellcomeopenres.17893.1
DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody
S Galli, L Melidis, S M Flynn, D Varshney, A Simeone, J Spiegel, S K Madden, D Tannahill and S Balasubramanian
Journal of the American Chemical Society, 2022, 144, 50, 23096–23103
DOI: 10.1021/jacs.2c10656#
Self-organization of plasticity and specialization in a primitively social insect
S Patalano, A Alsina, C Gregorio-Rodríguez, M Bachman, S Dreier, I Hernando-Herraez, P Nana, S Balasubramanian, S Sumner, W Reik and S Rulands
Cells Systems, 2022, 13:9, 768-700.e4
DOI: 10.1016/j.cels.2022.08.002
Early detection of cancer
D Crosby, S Bhatia, K M Brindle, L M Coussens, C Dive, M Emberton, S Esener, R C Fitzgerald, S S Gambhir, P Kuhn, T R Rebbeck and S Balasubramanian
Science, 2022, 375:6586
DOI: 10.1126/science.aay9040
G-quadruplex DNA structures in human stem cells and differentiation
K G Zyner, A Simeone, S M Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill and S Balasubramanian
Nature Communications, 2022, 13:142
DOI: 10.1038/s41467-021-27719-1
Single-cell mapping of DNA G-quadruplex structures in human cancer cells
W W I Hui, A Simeone, K Zyner, D Tannahill and S Balasubramanian
Scientific Reports, 2021, 11, 23641
DOI: 10.1038/s41598-021-02943-3
RNA G-quadruplex structures control ribosomal protein production
D Varshney, S Martínez Cuesta, B Herdy, U Abdullah, D Tannahill and S Balasubramanian
Scientific Reports, 2021, 11, 22735
DOI: 10.1038/s41598-021-01847-6
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells
X Zhang, J Spiegel, S Martínez Cuesta, S Adhikari and S Balasubramanian
Nature Chemistry, 2021, 13, 626–633
DOI: 10.1038/s41557-021-00736-9
Promoter G-quadruplex folding precedes transcription and is controlled by chromatin
J Shen, D Varshney, A Simeone, X Zhang, S Adhikari, D Tannahill and S Balasubramanian
Genome Biology, 2021, 22, 143
DOI: 10.1186/s13059-021-02346-7
G-quadruplexes are transcription factor binding hubs in human chromatin
J Spiegel, S Martinez Cuesta, S Adhikari, R Hänsel-Hertsch, D Tannahill and S Balasubramanian
Genome Biology, 2021, 22, 117
DOI: 10.1186/s13059-021-02324-z
TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions
R Broome, I Chernukhin, S Jamieson, K Kishore, E K Papachristou, S-Q Mao, C Gonzalez Tejedo, A Mahtey, V Theodorou, A J Groen, C D’Santos, S Balasubramanian, A Madalina Farcas, R Siersbæk, J S Carroll
Cell Reports, 2021, 34:8, 108776
DOI: 10.1016/j.celrep.2021.108776
