Small-molecule-mediated G-quadruplex isolation from human cells
S Müller, S Kumari, R Rodriguez and S Balasubramanian
Nature Chemistry, 2010, 2, 1095 – 1098
DOI: 10.1038/NCHEM.842
Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
M Bejugam, M Gunaratnam, S Müller, D A Sanders, S Sewitz, J A Fletcher, S Neidle and S Balasubramanian
ACS Med. Chem. Lett., 2010, 1, 306 – 310
DOI: 10.1021/ml100062z
Distinct functions of maternal and somatic Pat1 protein paralogs
A Marnef, M Maldonado, A Bugaut, S Balasubramanian, M Kress, D Weil and N Standart
RNA, 2010, 16, 2094 – 2107
DOI: 10.1261/rna.2295410
The BCL-2 5′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif that Modulates Protein Expression
R Shahid, A Bugaut and S Balasubramanian
Biochemistry, 2010, 49, 8300 – 8306
DOI: 10.1021/bi100957h
Small Molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
A Bugaut, R Rodriguez, S-T D Hsu and S Balasubramanian
Org. Biomol. Chem., 2010, 8, 2771 – 2776
DOI: 10.1039/c002418j
RNA Conformation in Catalytically Active Human Telomerase
J A Yeoman, A Orte, B Ashbridge, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2010, 132, 2852 – 2853
DOI: 10.1021/ja909383n
Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes
A Fegan, P S Shirude, L Ying and S Balasubramanian
Chem. Commun., 2010, 46, 946 – 948
DOI: 10.1039/b920680a
Single-Molecule Analysis of the Human Telomerase RNA·Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations
B Ashbridge, A Orte, J A Yeoman, M Kirwan, T Vulliamy, I Dokal, D Klenerman and S Balasubramanian
Biochemistry, 2009, 48, 10858 – 10865
DOI: 10.1021/bi901373e
Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
H Fernando, S Sewitz, J Darot, S Tavaré, J L Huppert and S Balasubramanian
Nucleic Acids Research, 2009, 37, 6716 – 6722
DOI: 10.1093/nar/gkp740
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
N J Lehrbach, J Armisen, H L Lightfoot, K J Murfitt, A Bugaut, S Balasubramanian and E A Miska
Nature Structural & Molecular Biology, 2009, 16, 1016 – 1020
DOI:10.1038/nsmb.1675
A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
S-T Hsu, P Varnai, A Bugaut, A P Reszka, S Neidle and S Balasubramanian
J. Am. Chem. Soc., 2009, 131, 13399 – 13409
DOI: 10.1021/ja904007p
G-quadruplex DNA bound by a synthetic ligand is highly dynamic
P V Jena, P S Shirude, B Okumus, K Laxmi-Reddy, F Godde, I Huc, S Balasubramanian and T Ha
J. Am. Chem. Soc., 2009, 131, 12522 – 12523
DOI: 10.1021/ja903408r
A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
Z A E Waller, S A Sewitz, S-T Hsu and S Balasubramanian
J. Am. Chem. Soc., 2009, 131, 12628 – 12633
DOI: 10.1021/ja901892u
G-quadruplex nucleic acids as therapeutic targets
S Balasubramanian and S Neidle
Curr. Opin. Chem. Bio., 2009, 13, 345 – 353
DOI: 10.1016/j.cbpa.2009.04.637
Controlled-folding of a small molecule modulates DNA G-quadruplex recognition
S Müller, G Dan Pantos, R Rodriguez and S Balasubramanian
Chem. Commun., 2009, 80 – 82
DOI: 10.1039/B816861J
Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
J E Redman, J M Granadino-Roldán, J A Schouten, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2009, 7, 76 – 84
DOI: 10.1039/b814682a
FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
T B C London, L J Barber, G Mosedale, G P Kelly, S Balasubramanian, I D Hickson, S J Boulton and K Hiom
J. Biol. Chem., 2008, 283, 36132 – 36139
DOI: 10.1074/jbc.M808152200
Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of the NRAS Proto-oncogene
S Kumari, A Bugaut and S Balasubramanian
Biochemistry, 2008, 47, 12664 – 12669
DOI: 10.1021/bi8010797
Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes
J Dash, P S Shirude, S-T D Hsu and S Balasubramanian
J. Am. Chem. Soc., 2008, 130, 15950 – 15956
DOI: 10.1021/ja8046552
A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
R Rodriguez, S Müller, J A Yeoman, C Trentesaux, J-F Riou and S Balasubramanian
J. Am. Chem. Soc., 2008, 130, 15758 – 15759
DOI: 10.1021/ja805615w
Accurate whole human genome sequencing using reversible terminator chemistry
D R Bentley, S Balasubramanian, H P Swerdlow et al.
Nature, 2008, 456, 53 – 59
DOI: 10.1038/nature07517
G-quadruplexes: the beginning and end of UTRs
J L Huppert, A Bugaut, S Kumari and S Balasubramanian
Nucleic Acids Res., 2008, 36, 6260 – 6268
DOI: 10.1093/nar/gkn511
Selective Recognition of a DNA G-Quadruplex by an Engineered Antibody
H Fernando, R Rodriguez and S Balasubramanian
Biochemistry, 2008, 47, 9365 – 9371
DOI: 10.1021/bi800983u
Single molecule conformational analysis of DNA G-quadruplexes
P S Shirude and S Balasubramanian
Biochimie, 2008, 90, 1197 – 1206
DOI: 10.1039/b801465e
G-quadruplex recognition by bis-indole carboxamides
J Dash, P S Shirude and S Balasubramanian
Chem. Commun., 2008, 3055 – 3057
DOI: 10.1039/b806042h
Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC
P S Shirude, L Ying and S Balasubramanian
Chem. Commun., 2008, 2007 – 2009
DOI: 10.1039/b801465e
Rigid cyanine dye nucleic acid labels
A Fegan, P S Shirude and S Balasubramanian
Chem. Commun., 2008, 2004 – 2006
DOI: 10.1039/b801629a
Single-molecule analysis of human telomerase monomer
D Alves, H Li, R Codrington, A Orte, X Ren, D Klenerman and S Balasubramanian
Nature Chemical Biology, 2008, 4, 287 – 289
DOI: 10.1038/nchembio.82
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry
A Bugaut, K Jantos, J-L Wietor, R Rodriguez, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 2008, 47, 2677 – 2680
DOI: 10.1002/anie.200705589
Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition
Z A E Waller, P Shirude, R Rodriguez and S Balasubramanian
Chem. Commun., 2008, 1467 – 1469
DOI: 10.1039/b718854d
A Sequence-Independent Study of the Influence of Short Loop Lengths on the Stability and Topology of Intramolecular DNA G-Quadruplexes
A Bugaut and S Balasubramanian
Biochemistry, 2008, 47, 689 – 697
DOI: 10.1021/bi701873c1
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression
M Bejugam, S Sewitz, S P Shirude, R Rodriquez, R Shahid and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 12926 – 12927
DOI: 10.1021/ja075881p
Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands
P S Shirude, E R Gillies, S Ladame, F Godde, K Shin-ya, I Huc and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 11890 – 11891
DOI: 10.1021/ja073775h
Ligand-Driven G-Quadruplex Conformational Switching By Using an Unusual Mode of Interaction
R Rodriguez, G Dan Pantos, D P N Goncalves, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 2007, 46, 5404 – 5407
DOI: 10.1002/anie.200605075
Single-Molecule Conformational Analysis of G-Quadruplex Formation in the Promoter DNA Duplex of the Proto-Oncogene C-Kit
P S Shirude, B Okumus, L Ying, T Ha and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 7484 – 7485
DOI: 10.1021/ja070497d
An RNA G-quadruplex in the 5‘ UTR of the NRAS proto-oncogene modulates translation
S Kumari, A Bugaut, J L Huppert and S Balasubramanian
Nature Chemical Biology, 2007, 3, 218 – 221
DOI: 10.1038/nchembio864
G-quadruplexes in promoters throughout the human genome
J L Huppert and S Balasubramanian
Nucleic Acids Res., 2007, 35, 2, 406 – 413
DOI: 10.1093/nar/gkm109
Tetramethylpryidiniumporphyrazines – a new class of G-quadruplex inducing and stabilising ligands
D P Goncalves, R Rodriguez, S Balasubramanian and J K M Sanders
Chem. Commun., 2006, 4685 – 4687
DOI: 10.1039/b611731g
Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
J E Redman, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2006, 4, 4364 – 4369
DOI: 10.1039/B611716C
A Simple Nanomixer for Single-Molecule Kinetics Measurements
S S White, S Balasubramanian, D Klenerman and L Ying
Angew. Chem. Int. Ed., 2006, 45, 7540 – 7543
DOI: 10.1002/anie.200602289
Determination of the Fraction and Stoichiometry of Femtomolar Levels of Biomolecular Complexes in an Excess of Monomer Using Single-Molecule, Two-Color Coincidence Detection
A Orte, R Clarke, S Balasubramanian and D Klenerman
Anal. Chem., 2006 78, 7707 – 7715
DOI: 10.1021/ac061122y
Structural Analysis of the Catalytic Core of Human Telomerase RNA by FRET and Molecular Modeling
G Gavory, M F Symmons, Y Krishnan Ghosh, D Klenerman and S Balasubramanian
Biochemistry, 2006, 45, 13304 – 13311
DOI: 10.1021/bi061150a
Oxazole-Based Peptide Macrocycles: A New Class of G-Quadruplex Binding Ligands
K Jantos, R Rodriguez, S Ladame, P S Shirude and S Balasubramanian
J. Am. Chem. Soc., 2006, 128, 13662 – 13663
DOI: 10.1021/ja064713e
Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
D P N Goncalves, S Ladame, S Balasubramanian and J K M Sanders
Org. Biomol. Chem., 2006, 4, 3337 – 3342
DOI: 10.1039/b608494j
Investigating a quadruplex-ligand interaction by unfolding kinetics
J J Green, S Ladame, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2006, 126, 9809 – 9812
DOI: 10.1021/ja0615425
A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
H Fernando, A P Reszka, J Huppert, S Ladame, S Rankin, A R Venkitaraman, S Neidle and S Balasubramanian
Biochemistry, 2006, 45, 7854 – 7860
DOI: 10.1021/bi0601510
Analysis of Human Telomerase Activity and Function by Two Color Single Molecule Coincidence Fluorescence Spectroscopy
X Ren, H Li, R W Clarke, D A Alves, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2006, 128, 4992 – 5000
DOI: 10.1021/ja056613z
A Reversible pH-Driven DNA Nanoswitch Array
D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman and D Zhou
J. Am. Chem. Soc., 2006, 128, 2067 – 2071
DOI: 10.1021/ja0568300
Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein
S Ladame, J A Schouten, J Roldan, J E Redman, S Neidle and S Balasubramanian
Biochemistry, 2006, 45, 1393 – 1399
DOI: 10.1021/bi050229x
