Research

Pre 2000 papers

31

Screening for Oligonucleotide Binding Affinity by a Convenient Fluorescence Competition Assay

J G Harrison, X Liu and S Balasubramanian
Nucleic Acids Research, 1999, 27, e14
DOI: 10.1093/nar/27.17.e14

30

Thermodynamic Melting Studies on Oligonucleotide-Peptide Conjugates

C Frier, J G Harrison and S Balasubramanian
Nucleosides and Nucleotides, 1999, 18, 1477 – 1478
DOI: 10.1080/07328319908044758

29

Solid-phase synthesis: designer linkers for combinatorial chemistry

K Gordon and S Balasubramanian
J.Chem. Tech. Biotech., 1999, 74, 835 – 851
DOI: 10.1002/(SICI)1097-4660(199909)74:9<835::AID-JCTB130>3.0.CO;2-Z

28

Recent advances in solid-phase chemical methodologies

K Gordon and S Balasubramanian
Current Opinion in Drug Discovery and Development, 1999, 2, 342 – 349

27

Exploring a chemical encoding strategy for combinatorial synthesis using Friedels-Craft alkylation

R H Scott, C Barnes U Gerhard and S Balasubramanian
Chem. Commun., 1999, 1331-1332
DOI: 10.1039/A902489A

26

Studies on Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid Phase Synthesis

H B Lee and S Balasubramanian

J. Org. Chem., 1999, 64, 3454 – 3460; 1999, 64, 5728 (legend correction)
DOI: 10.1021/jo981987e

25

Inhibition of Human Telomerase by PNA- Cationic Peptide Conjugates

J G Harrison, C Frier, R Laurant, K D Raney and S Balasubramanian
Bioorg. Med. Chem. Lett., 1999, 9, 1273 – 1278
DOI: 10.1016/S0960-894X(99)00170-5

24

Progress in Chemical Encoding for Combinatorial Synthesis


C Barnes, R H Scott and S Balasubramanian
Recent Res. Devel. in Organic Chem., 1998, 2, 367 – 379
DOI: 10.1002/chin.199946279

23

Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates

J G Harrison and S Balasubramanian
Nucleic Acids Res., 1998, 26, 3136 – 3145
DOI: 10.1093/nar/26.13.3136

22

Optically Biased Diffusion of Single Molecules Studied by Confocal Fluorescence Microscopy


M A Osbourne, S Balasubramanian, W S Furey and D Klenerman

J. Phys. Chem. B, 1998, 102, 3160 – 3167
DOI: 10.1021/jp9715078

21

Use of Fluorescence Resonance Energy Transfer to Investigate the Conformation of DNA Substrates Bound to the Klenow Fragment

W S Furey, C M Joyce, M A Osbourne, D Klenerman, J A Peliska and S Balasubramanian
Biochemistry, 1998, 37, 2979 – 2990
DOI: 10.1021/bi9719758

20

A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine peptide Library


Y W Cheung, C Abell and S Balasubramanian
J. Am. Chem. Soc., 1997, 119, 9568 – 9569
DOI: 10.1021/ja971825k

19

Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids

M H Todd, S Balasubramanian and C Abell
Tetrahedron Lett., 1997, 38, 6781 – 6784
DOI: 10.1016/S0040-4039(97)01552-9

18

Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support

V Arumugam, A Routledge, C Abell and S Balasubramanian
Tetrahedron Lett., 1997, 38, 6473 – 6476
DOI: 10.1016/S0040-4039(97)01481-0

17

Properties of Fluorophores on Solid Phase Resins; Implications for Screening, Encoding and Reaction Monitoring

R H Scott and S Balasubramanian
Bioorg. Med. Chem. Lett., 1997, 7, 1567 – 1572
DOI: 10.1016/S0960-894X(97)00263-1

16

A Convenient Synthetic Route to Oligonucleotide Conjugates

J G Harrison and S Balasubramanian
Bioorg. Med. Chem. Lett., 1997, 7, 1041 – 1046
DOI: 10.1016/S0960-894X(97)00152-2

15

The Use of a Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis

A Routledge, C Abell and S Balasubramanian

Tetrahedron Lett., 1997, 38, 1227 – 1230
DOI: 10.1016/S0040-4039(96)02478-1

14

An Investigation into Solid-Phase Radical Chemistry – Synthesis of Furan Rings


A Routledge, C Abell and S Balasubramanian

SynLett., 1997, 61 – 62
DOI: 10.1055/s-1997-704

13

Solid Phase Reductive Alkylation of Secondary Amines

N K Khan, V Arumugam and S Balasubramanian
Tetrahedron Lett., 1996, 37, 4819 – 4822
DOI: 10.1016/0040-4039(96)00945-8

12

Escherichia coli Chorismate Synthase Catalyses the Conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate


S Bornemann, M K Ramjee, S Balasubramanian, C Abell, J R Coggins, D J Lowe and R N F Thorneley
J. Biol. Chem., 1995, 270, 22811 – 22815
DOI: 10.1074/jbc.270.39.22811

11

The Mechanism of Metal Independent Hydroxylation by Chromobacterium violaceum Phenylalanine Hydroxylase

R T Carr, S Balasubramanian, P Hawkins and S J Benkovic

Biochemistry, 1995, 34, 7525 – 7532
DOI: 10.1021/bi00022a028

10

Escherichia coli Chorismate Synthase: A Deuterium Kinetic Isotope Effect Under Single Turnover and Steady State Conditions shows that a Flavin Intermediate forms before the C-(6proR)-H bond is cleaved

S Bornemann, S Balasubramanian, J R Coggins, C Abell, D J Lowe and R N F Thorneley

Biochem. J., 1995, 305, 707 – 710
DOI: 10.1042/bj3050707

9

Observation of a Secondary Tritium Isotope Effect in the Reaction Catalyzed by Neurospora Crassa Chorismate Synthase

S Balasubramanian, J R Coggins and C Abell
Biochemistry, 1995, 34, 341 – 348
DOI: 10.1021/bi00001a042

8

Recombinant HIV-1 Nucleocapsid Protein Accelerates HIV-1 Reverse Transcriptase Catalyzed DNA Strand Transfer Reactions and Modulates RNase H Activity


J A Peliska, S Balasubramanian, D P Giedroc and S J Benkovic
Biochemistry, 1994, 33, 13817 – 13823
DOI: 10.1021/bi00250a036

7

Identification of Metal Ligands in Cu(II) Inhibited Chromobacterium violaceum Phenylalanine Hydroxylase by Electron Spin Echo Envelope Modulation Analysis of Histidine to Serine Mutations


S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic

Biochemistry, 1994, 33, 8532 – 8537
DOI: 10.1021/bi00194a019

6

Studies on Escherichia coli Chorismate Synthase

S Borneman, M N Ramjee, D J Lowe, R N F Thorneley, J R Coggins, C Abell, S Balasubramanian, T R Hawkes, W W Nichols and G M Davies
Flavins and Flavoproteins, (Ed. K. Yagi) 843-846. Walter de Gruyer, Berlin, New York, 1994

5

Histidines 138 and 143 are Copper Binding Ligands in Chromobacterium violaceum Phenylalanine Hydroxylase

S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic
Chemistry and Biology of Pteridines and Folates, Eds. J.E. Ayling, M.G. Nair, and C.M. Baugh, 1993, 67 – 71
DOI: 10.1007/978-1-4615-2960-6_13

4

Reaction of (6R)-6-F-EPSP with Recombinant Escherichia coli Chorismate Synthase Generates a Stable Flavin Mononucleotide Semiquinone Radical

M N Ramjee, S Balasubramanian, C Abell, J R Coggins, G M Davies, T R Hawkes, D J Lowe and R N F Thorneley
J. Am. Chem. Soc., 1992, 114, 3151 – 3153
DOI: 10.1021/ja00034a079

3

Inhibition of Chorismate Synthase by (6R)- and (6S)-6-Fluoro-5-enolpyruvylshikimate 3-Phosphate


S Balasubramanian, G M Davies, J R Coggins and C Abell
J. Am. Chem. Soc., 1991, 113, 8945 – 8946
DOI: 10.1021/ja00023a051

2

The Synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-Enolpyruvylshikimate 3-Phosphate

S Balasubramanian and C Abell
Tetrahedron Lett., 1991, 32, 963 – 966
DOI: 10.1016/S0040-4039(00)92131-2

1

Observation of an Isotope Effect in the Chorismate Synthase Reaction

S Balasubramanian, C Abell and J R Coggins

J. Am. Chem. Soc., 1990, 112, 8581-858
DOI: 10.1021/ja00179a052