Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis
M Nappi, A Hofer, S Balasubramanian and M Gaunt
J. Am. Chem. Soc., 2020, 21484-21492
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Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma
Y-Z Xu, P Jenjaroenpun, T Wongsurawat, S D Byrum, V Shponka, D Tannahill, E AnChavez, S S Hung, C Steidl, S Balasubramanian, L M Rimsza and S Kendrick
NAR Cancer, 2020, 2:4, zcaa029
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Natural, modified DNA bases
M Bilyard, S Becker and S Balasubramanian
Currently. Op. in Chemistry. Bio., 2022, 57, 1-7
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Landscape of G-quadruplex DNA structural regions in breast cancer
R Hänsel-Hertsch, A Simeone, A Shea, W Hui, K Zyner, G Marsico, O Rueda, A Bruna, A Martin, X Zhang, S Adhikari, D Tannahill, C Caldas and S Balasubramanian
Nature Genetics, 2020, 52, 878-883
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Single-molecule visualization of DNA G-quadruplex formation in live cells
M Di Antonio, A Ponjavic, A Radzevičius, R T Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, S F Lee, D Klenerman and S Balasubramanian
Nature Chemistry, 2020, 12, 832–837
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Genome-wide DNA Methylation Signatures Are Determined by DNMT3A/B Sequence Preferences
S-Q Mao, S Martinez Cuesta, D Tannahill and S Balasubramanian
Biochemistry, 2020, 59, 27, 2541–2550
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The regulation and functions of DNA and RNA G-quadruplexes
D Varshney, J Spiegel, K Zyner, D Tannahill and S Balasubramanian
Nature Reviews Molecular Cell Biology, 2020, 21, 459–474
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Affinity-selected bicyclic peptide G-quadruplex ligands mimic a protein-like binding mechanism
K C Liu, K Röder, C Mayer, S Adhikari, D J Wales and S Balasubramanian
J. Am. Chem. Soc., 2020, 142, 18, 8367-8373
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The structure and function of DNA G-Quadruplexes
J Spiegel, S Adhikari and S Balasubramanian
Trends in Chemistry, 2020, 2:2, 123-136
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A Spontaneous Ring‐Opening Reaction Leads to a Repair‐Resistant Thymine Oxidation Product in Genomic DNA
A Sahakyan, A Mahtey, F Kawasaki and S Balasubramanian
Chem. Bio. Chem., 2020, 21, 320-323
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An Activatable Cancer-Targeted Hydrogen Peroxide Probe for Photoacoustic and Fluorescence Imaging
J Weber, L Bollepalli, A Belenguer, M Di Antonio, N De Mitri, J Joseph, S Balasubramanian, C Hunter and S Bohndiek
Cancer Res., 2019, 79, 5407
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Unusual Activity of a Chlamydomonas TET/JBP Family Enzyme
L Aravind, S Balasubramanian and A Rao
Biochemistry, 2019, 58, 3627-3629
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Genetic interactions of G-quadruplexes in humans
K Zyner, D Mulhearn, S Adhikari, S Martínez Cuesta, M Di Antonio, N Erard, G Hannon, D Tannahill and S Balasubramanian
eLife, 2019, 8:e46793
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Sequencing abasic sites in DNA at single-nucleotide resolution
Z Liu, S Martínez Cuesta, P van Delft and S Balasubramanian
Nature Chemistry, 2019, 11, 629-637
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A Photo‐responsive Small‐Molecule Approach for the Opto‐epigenetic Modulation of DNA Methylation
H P Nguyen, S Stewart, M N Kukwikila, S F Jones, D Offenbartl-Stiegert, S Mao, S Balasubramanian, S Beck and S Howorka
Angew. Chem. Int. Ed., 2019, 58, 6620-6624
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METTL1 Promotes let-7 MicroRNA Processing via m7G Methylations
L Pandolfini, I Barbieri, A Bannister, A Hendrick, B Andrews, N Webster, P Murat, P Mach, R Brandi, S Robson, V Migliori, A Alendar, M d’Onofrio, S Balasubramanian and T Kouzarides
Molecular Cell, 2019, 74, 1-13
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Detection, Structure and Function of Modified DNA Bases
A Hofer, Z Liu, S Balasubramanian
J. Am. Chem. Soc., 2019, 141, 16, 6420-6429
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Whole genome experimental maps of DNA G-quadruplexes in multiple species
G Marsico, V S Chambers, A B Sahakyan, P McCauley, J M Boutell, M Di Antonio, S Balasubramanian
Nucleic Acids Research, 2019, 47:8, 3862-3874
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Structure of (3+1) hybrid G-quadruplex in the PARP1 promoter
A Sengar, J J Vandana, V S Chambers, M Di Antonio, F R Winnerdy, S Balasubramanian, A T Phan
Nucleic Acids Research, 2018, 47:3, 1564–1572
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RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs
P Murat, G Marsico, B Herdy, A Ghanbarian, G Portella and S Balasubramanian
Genome Biology, 2018, 9:229
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5-Formylcytosine organises nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells
E-A Raiber, G Portella, S Martinez Cuesta, R Hardisty, P Murat, Z Li, M Iurlaro, W Dean, J Spindel, D Beraldi, Z Liu, M Dawson, W Reik and S Balasubramanian
Nature Chemistry, 2018, 10, 1258–1266
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DNA G-quadruplex structures mold the DNA methylome
S-Q Mao, A T Ghanbarian, J Spiegel, S Martinez Cuesta, D Beraldi, M Di Antonio, G Marsico, R Hansel-Hertsch, D Tannahill and S Balasubramanian
Nature Structural & Molecular Biology, 2018, 25, 951–957
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Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts
B Herdy, C Mayer, D Varshney, G Marsico, P Murat, C Taylor, C D’Santos, D Tannahill and S Balasubramanian
Nucleic Acids Research, 2018, 46:21, 11592–11604
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Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome
C K Kwok, G Marsico, S Balasubramanian
Cold Spring Harb. Prospect. Biol., 2018, 10:a032284
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Sequencing 5‐Hydroxymethyluracil at Single‐Base Resolution
F Kawasaki, S Martinez Cuesta, D Beraldi, A Mahtey, R Hardisty, M Carrington, S Balasubramanian
Angew. Chem. Int. Ed., 2018, 57 (31), 9694-9696
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Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36
M C Chen, R Tippana, N A Demeshkina, P Murat, S Balasubramanian, S Myong and A R Ferré-D’Amaré
Nature, 2018, 558, 465–469
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NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
A Parry, M Hoare, D Bihary, R Hansel-Hertsch, S Smith, K Tomimatsu, E Mannion, A Smith, P D’Santos, A Russell, S Balasubramanian, H Kimura, S Samarajiwa and M Narita
Nature Communications, 2018, 9, 1840
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Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing
R Hansel-Hertsch, J Spiegel, G Marsico, D Tannahill and S Balasubramanian
Nature Protocols, 2018, 13, 551-564
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Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule
C Marchetti, K G Zyner, S A Ohnmacht, M Robson, S M Haider, J P Morton, G Marsico, T Vo, S Laughlin-Toth, A A Ahmed, G Di Vita, I Pazitna, M Gunaratnam, R J Besser, A C G Andrade, S Diocou, J A Pike, D Tannahill, R B Pedley, T R J Evans, W D Wilson, S Balasubramanian and S Neidle
J. Med. Chem., 2018, 61 (6), 2500–2517
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Machine learning model for sequence-driven DNA G-quadruplex formation
A Sahakyan, V S Chambers, G Marsico, T Santner, M Di Antonio and S Balasubramanian
Scientific Reports, 2017, 7, 14535
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DNA sequencing at 40: past, present and future
J Shendure, S Balasubramanian, G M Church, W Gilbert, J Rogers, J A Schloss and R H Waterson
Nature, 2017, 550, 345-353
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Therapeutics: Click and discover
G Vassiliou and S Balasubramanian
Nature, 2017, 548, 162-164
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Synthesis and multiple incorporations of 2′-O-methyl-5-hydroxymethyl-, 5-hydroxymethyl- and 5-formylcytidine monomers into RNA oligonucleotides
A Tanpure and S Balasubramanian
ChemBioChem, 2017, 18, 2236 –2241
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Mapping and elucidating the function of modified bases in DNA
E-A Raiber, R Hardisty, P van Delft and S Balasubramanian
Nature Review Chemistry, 2017, 1, 0069
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Local epigenetic reprogramming induced by G-quadruplex ligands
G Guilbaud, P Murat, B Recolin, B Campbell, A Maiter, J E Sale and S Balasubramanian
Nature Chemistry, 2017, 9, 1110-1117
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The profile and dynamics of RNA modifications in animals
P Van Delft, A Akay, S M Huber, C Bueschl, K L M Rudolph, T Di Domenico, R Schuhmacher, E A Miska and S Balasubramanian
ChemBioChem, 2017, 18, 979-984
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Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma
E-A Raiber, D Beraldi, S Martínez Cuesta, G R McInroy, Z Kingsbury, J Becq, T James, M Lopes, K Allinson, S Field, S Humphray, T Santarius, C Watts, D Bentley and S Balasubramanian
npj Genomic Medicine, 2017, 2:6
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DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
R Hänsel-Hertsch, M Di Antonio and S Balasubramanian
Nature Reviews Molecular Cell Biology, 2017, 18, 279–284
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, N J O’Neil, N Dos Santos, J Silvester, V Wei, J Garcia, F Kabeer, D Lai, P Soriano, J Banáth, D S Chiu, D Yap, D D Le, F B Ye, A Zhang, K Thu, J Soong, S Lin, A Hsin Chin Tsai, T Osako, T Algara, D N Saunders, J Wong, J Xian, M B Bally, J D Brenton, G W Brown, S P Shah, D Cescon, T W Mak, C Caldas, P C Stirling, P Hieter, S Balasubramanian and S Aparicio
Nature Communications, 2017, 8, 14432
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Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming
I Milagre, T M Stubbs, M R King, J Spindel, F Santos, F Krueger, M Bachman, A Segonds-Pichon, S Balasubramanian, S R Andrews, W Dean and W Reik
Cell Reports, 2017, 18:5, 1079–1089
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Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania
F Kawasaki, D Beraldi, R E Hardisty, G R McInroy, P van Delft and S Balasubramanian
Genome Biology, 2017, 18:23
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G-quadruplex structures within the 3’-UTR of LINE-1 elements stimulate retrotransposition
A B Sahakyan, P Murat, C Mayer and S Balasubramanian
Nature Str. Mol. Biol., 2017, 24, 243–247
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2′-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA
S M Huber, P van Delft, A Tanpure, E A Miska and S Balasubramanian
J. Am. Chem. Soc., 2017, 139 (5), 1766–1769
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Single genome retrieval of context-dependent variability in mutation rates for human germline
A B Sahakyan and S Balasubramanian
BMC Genomics, 2017, 18:81
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Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides
F Kawasaki, P Murat, Z Li, T Santner and S Balasubramanian
Chem. Comm., 2017, 53, 1389 – 1392
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Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms
T A Horea, F von Meyenna, M Ravichandranc, M Bachman, G Ficz, D Oxley, F Santosa, S Balasubramanian, T P Jurkowskic, and W Reik
PNAS, 2016, 113:42, 12202-12207
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Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
H L Lightfoot, E A Miska and S Balasubramanian
Org. Biomol. Chem., 2016, 14, 10208-10216
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G-quadruplex structures mark human regulatory chromatin
R Hänsel-Hertsch, D Beraldi, S V Lensing, G Marsico, K Zyner, A Parry, M Di Antonio, J Pike, H Kimura, M Narita, D Tannahill and S Balasubramanian
Nature Genetics, 2016, 48, 1267-1272
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rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
C K Kwok, G Marsico, A B Sahakyan, V S Chambers and S Balasubramanian
Nature Methods, 2016, 13, 841-844
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DSBCapture: in situ capture and sequencing of DNA breaks
S V Lensing, G Marsico, R Hänsel-Hertsch, E Y Lam, D Tannahill and S Balasubramanian
Nature Methods, 2016, 13, 855-857
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An Epigenetics-Inspired DNA-Based Data Storage System
C Mayer, G R McInroy, P Murat, P van Delft and S Balasubramanian
Angew. Chem. Int. Ed., 2016, 55:37, 11144-11148
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In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine
M Iurlaro, G R McInroy, H E Burgess, W Dean, E-A Raiber, M Bachman, D Beraldi, S Balasubramanian and W Reik
Genome Biology, 2016, 17:141
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Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA
C K Kwok, A Sahakyan and S Balasubramanian
Angew. Chem. Int. Ed., 2016, 55, 8958-8961
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Enhanced Methylation Analysis by Recovery of Unsequenceable Fragments
G R McInroy, D Beraldi, E-A Raiber, K Modrzynska, P van Delft, O Billker and S Balasubramanian
PLoS ONE, 2016, 3: e)152322
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Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases
A Sahakyan and S Balasubramanian
BMC Genomics, 2016, 17:225
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Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes
O S Walker, S J Elsas̈ser, M Mahesh, M Bachman, S Balasubramanian and J W Chin
J. Am. Chem. Soc., 2016, 138, 718 – 721
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Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies
S Patalano, A Vlasova, C Wyatt, P Ewels, F Camara, P G Ferreira, C L Asher, T P Jurkowski, A Segonds-Pichon, M Bachman, I González-Navarrete, A E Minoche, F Krueger, E Lowy, M Marcet-Houben, J L Rodriguez-Ales, F S Nascimento, S Balasubramanian, T Gabaldon, J E Tarver, S Andrews, H Himmelbauer, W O H Hughes, R Guigó, W Reik, and S Sumner
PNAS, 2016, 112, 13970 – 13975
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High-throughput sequencing of DNA G-quadruplex structures in the human genome
V S Chambers, G Marsico, J M Boutell, M Di Antonio, G P Smith and S Balasubramanian
Nature Biotechnology, 2015, 33, 877 – 881
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FOXM1 binds directly to non-consensus sequences in the human genome
D A Sanders, M V Gormally, G Marsico, D Beraldi, D Tannahill and S Balasubramanian
Genome Biology, 2015, 16:130
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5-Formylcytosine can be a stable DNA modification in mammals
M Bachman, S Uribe-Lewis, X Yang, H E Burgess, M Iurlaro, W Reik and S Balasubramanian
Nature Chemical Biology, 2015, 11, 555 – 557
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Selective Chemical Labeling of Natural T Modifications in DNA
R E Hardisty, F Kawasaki, A B Sahakyan and S Balasubramanian
J. Am. Chem. Soc., 2015, 137, 9270 – 9272
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C K Kwok and S Balasubramanian
Angew. Chem. Int. Ed., 2015, 54, 6751 – 6754
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G-quadruplex ligands exhibit differential G-tetrad selectivity
D D Le, M Di Antonio, L K M Chan, and S Balasubramanian
Chem. Commun., 2015, 51, 8048 – 8050
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Chemical Methods for Decoding Cytosine Modifications in DNA
M J Booth, E-A Raiber, and S Balasubramanian
Chem. Rev., 2015, 115, 2240 – 2254
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Accurate Measurement of 5-Methylcytosine and 5-Hydroxymethylcytosine in Human Cerebellum DNA by Oxidative Bisulfite on an Array (OxBS-Array)
S F Field, D Beraldi, M Bachman, S K Stewart, S Beck, and S Balasubramanian
PloS ONE, 2015, 10:e0118202t
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Formation and Abundance of 5-Hydroxymethylcytosine in RNA
S M Huber, P van Delft, L Mendil, M Bachman, K Smollett, F Werner, E A Miska and S Balasubramanian
ChemBioChem., 2015, 16, 752 – 755
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Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase
M C Chen, P Murat, K Abecassis, A R Ferre-D’Amare and S Balasubramanian
Nucleic Acids Res., 2015, 43, 2223 – 2231
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Decoding Genomes
S Balasubramanian
Biochem. Soc. Trans., 2015, 43, 1 – 5
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5-Formylcytosine alters the structure of the DNA double helix
E Raiber, P Murat, D Y Chirgadze, D Beraldi, B F Luisi and S Balasubramanian
Nature Structural & Molecular Biology, 2015, 22, 44 – 49
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Dual binding of an antibody and a small molecule increases the stability of the TERRA G-quadruplex
P M Yangyuoru, M Di Antonio, C Ghimire, G Biffi, S Balasubramanian, and H Mao
Angew. Chem. Int. Ed., 2015, 54, 910 – 913
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oxBS-450K: A method for analysing hydroxymethylation using 450K BeadChips
S K Stewart, T J Morris, P Guilhamon, H Bulstrode, M Bachman, S Balasubramanian and S Beck
Methods, 2015, 72, 9 – 15
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Solexa Sequencing: Decoding Genomes on a Population Scale
S Balasubramanian
Clin. Chem., 2015, 61, 21 – 24
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Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition
M V Gormally, T S Dexheimer, G Marsico, D A Sanders, C Lowe, D Matak-Vinković, S Michael, A Jadhav, G Rai, D J Maloney, A Simeonov and S Balasubramanian
Nature Communications, 2014, 5:5165
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Targeting DNA G-Quadruplexes with Helical Small Molecules
S Müller, K Laxmi-Reddy, PV Jena, B Baptiste, Z Dong, F Godde, T Ha, R Rodriguez, S Balasubramanian and I Huc
Chembiochem., 2014, 15, 2563 – 2570
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Nucleotide contributions to the structural integrity and DNA replication initiation activity of noncoding Y RNA
I Wang, M P Kowalski, A R Langley, R Rodriguez, S Balasubramanian, S T Hsu, and T Krude
Biochemistry, 2014, 53, 5848 – 5863
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5-Hydroxymethylcytosine is a predominantly stable DNA modification
M Bachman, S Uribe-Lewis, X Yang, M Williams, A Murrell and S Balasubramanian
Nature Chemistry, 2014, 6, 1049 – 1055
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Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells
D Schiavone, G Guilbaud, P Murat, C Papadopoulou, P Sarkies, M Prioleau, S Balasubramanian and J E Sale
The EMBO Journal, 2014, 33, 2507 – 2520
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Chemical biology on genomic DNA: minimizing PCR bias
G McInroy, E Raiber, and S Balasubramanian
Chem. Commun., 2014, 50, 12047 – 12049
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Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer
G Biffi, D Tannahill, J Miller, W J Howat and S Balasubramanian
PLoS ONE, 2014, 9, e102711
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Chemical Biology on the Genome
S Balasubramanian
Bioorg. Med. Chem.,2014, 22, 4356 – 4370
DOI: 10.1016/j.bmc.2014.05.016
Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand
M Di Antonio, K I E McLuckie, and S Balasubramanian
J. Am. Chem. Soc., 2014, 136, 5860 – 5863
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Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution
M J Booth, G Marsico, M Bachman, D Beraldi, and S Balasubramanian
Nature Chemistry, 2014, 6, 435 – 440
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G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation
P Murat, J Zhong, L Lekieffre, N P Cowieson, J L Clancy, T Preiss, S Balasubramanian, R Khanna and J Tellam
Nature Chemical Biology, 2014, 10, 358 – 364
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Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells
G Biffi, M Di Antonio, D Tannahill and S Balasubramanian
Nature Chemistry, 2014, 6, 75 – 80
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Targeting a c-MYC G-quadruplex DNA with a fragment library
H R Nasiri, N Bell, K McLuckie, J Husby, C Abell, S Neidle and S Balasubramanian
Chem. Commun., 2014, 50, 1704 – 1707
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Existence and consequences of G-quadruplex structures in DNA
P Murat and S Balasubramanian
Curr. Opin. Genet. Dev., 2014, 25, 22 – 29
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The binding interaction between long non-coding RNA HOTAIR and PRC2 proteins
L Wu, P Murat, D Matak-Vinkovic, A Murrell and S Balasubramanian
Biochemistry, 2013, 52, 9519 – 9527
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Targeting RNA-Protein Interactions within the Human Immunodeficiency Virus Type 1 Lifecycle
N Bell, A L’Hernault, P Murat, J E Richards, A M Lever, and S Balasubramanian
Biochemistry, 2013, 52, 9269 – 9274
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Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes
P Yangyuoru, A Zhang, Z Shi, D Koirala, S Balasubramanian and H Mao
ChemBioChem., 2013, 14, 1931 – 1935.
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A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
M Iurlaro, G Ficz, D Oxley, E Raiber, M Bachman, M J Booth, S Andrews, S Balasubramanian and W Reik
Genome Biology, 2013, 14:R119
DOI: 10.1186/gb-2013-14-10-r119
Oxidative Bisulfite sequencing of 5-methylcytosine and 5-hydroxymethlcytosine
M J Booth, T W B Ost, D Beraldi, N Bell, M Branco, W Reik and S Balasubramanian
Nature Protocols, 2013, 8, 1841 – 1851
DOI: 10.1038/nprot.2013.115
Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
P Murat, M V Gormally, D Sanders, M Di Antonio and S Balasubramanian
Chem. Commun., 2013, 49, 8453 – 8455
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G-quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
K I E McLuckie, M Di Antonio, H Zecchini, J Xian, C Caldas, B F Krippendorff, D Tannahill, C Lowe and S Balasubramanian
J. Am. Chem. Soc., 2013, 135, 9640 – 9643
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G-quadruplex structures are stable and detectable in human genomic DNA
E Yi Ni Lam, D Beraldi, D Tannahill and S Balasubramanian
Nature Communications, 2013, 4, 1796
DOI: 10.1038/ncomms2792
Down-regulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer
T Mitchell, A Ramos-Montoya, M Di Antonio, P Murat, S Ohnmacht, M Micco, S Jurmeister, L Fryer, S Balasubramanian, S Neidle and D E Neal
Biochemistry, 2013, 52, 1429 – 1436
DOI: 10.1021/bi301349c
Genome-wide mapping of FOXM1 binding reveals co binding with estrogen receptor alpha in breast cancer cells
D A Sanders, C S Ross-Innes, D Beraldi, J S Carroll and S Balasubramanian
Genome Biology, 2013, 14:R6
DOI: 10.1186/gb-2013-14-1-r6
Quantitative visualization of DNA G-quadruplex structures in human cells
G Biffi, D Tannahill, J McCafferty and S Balasubramanian
Nature Chemistry, 2013, 5, 182 – 186
DOI: 10.1038/nchem.1548
An Acetylene-Bridged 6,8-Purine Dimer as a Fluorescent Switch-On Probe for Parallel G-Quadruplexes
M Nikan, M Di Antonio, K Abecassis, K McLuckie and S Balasubramanian
Angew. Chem. Int. Ed. , 2013, 52, 1428 – 1431
DOI: 10.1002/anie.201207075
An RNA Hairpin to G-Quadruplex Conformational Transition
A Bugaut, P Murat and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 19953 – 19956
DOI: 10.1021/ja308665g
The Kinetics and Folding Pathways of Intramolecular G-Quadruplex Nucleic Acids
A Zhang and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 19297 – 19308
DOI: 10.1021/ja309851t
Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry
M Di Antonio, G Biffi, A Mariani, E-A Raiber, R Rodriguez and S Balasubramanian
Angew. Chem. Int. Ed, 2012, 51, 11073 – 11078
DOI: 10.1002/anie.201206281
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
S Müller, D A Sanders, M Di Antonio, S Matsis, J F Riou, R Rodriguez and S Balasubramanian
Org. Biomol. Chem., 2012, 10, 6537 – 6546
DOI: 10.1039/C2OB25830G
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase
E-A Raiber, D Beraldi, G Ficz, H Burgess, M R Branco, P Murat, D Oxley, M J Booth, W Reik and S Balasubramanian
Genome Biology, 2012, 13:R69
DOI: 10.1186/gb-2012-13-8-r69
An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2
G Biffi, D Tannahill and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 11974 – 11976
DOI: 10.1021/ja305734x
50-UTR RNA G-quadruplexes: translation regulation and targeting
A Bugaut and S Balasubramanian
Nucleic Acids Res., 2012, 40, 4727 – 4741
DOI: 10.1093/nar/gks068
Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution
M J Booth, M R Branco, G Ficz, D Oxley, F Krueger, W Reik and S Balasubramanian
Science, 2012, 336, 934 – 937
DOI: 10.1126/science.1220671
Experimental Approaches to Identify Cellular G-quadruplex Structures and Functions
M Di Antonio, R Rodriguez and S Balasubramanian
Methods, 2012, 57, 84 – 92
DOI: 10.1016/j.ymeth.2012.01.008
Comparative Structural Effects of HIV-1 Gag and Nucleocapsid Proteins in Binding to and Unwinding of the Viral RNA Packaging Signal
N M Bell, J C Kenyon, S Balasubramanian and A M L Lever
Biochemistry, 2012, 51, 3162 – 3169
DOI: 10.1093/nar/gks068
Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
R Rodriguez, K M Miller, J V Forment, C R Bradshaw, M Nikan, S Britton, T Oelschlaegel, B Xhemalce, S Balasubramanian and S P Jackson
Nature Chemical Biology, 2012, 8, 301 – 310
DOI: 10.1038/nchembio.780
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
P Sarkies, P Murat, L G Phillips, K J Patel, S Balasubramanian and J E Sale
Nucleic Acids Res., 2012, 40, 1485 – 1498
DOI: 10.1093/nar/gkr868
A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
E-A Raiber, R Kranaster, E Lam, M Nikan and S Balasubramanian
Nucleic Acids Res., 2012, 40, 1499 – 1508
DOI: 10.1093/nar/gkr882
Demonstration of Ligand Decoration, and Ligand-Induced Perturbation, of G-Quadruplexes in a Plasmid Using Atomic Force Microscopy
I Mela, R Kranaster, R M Henderso, S Balasubramanian and J M Edwardson
Biochemistry, 2012, 51, 578 – 585
DOI: 10.1021/bi201600g
Synthesis of Bis-indole Carboxamides as G-Quadruplex Stabilizing and Inducing Ligands
J Dash, R N Das, N Hegde, G D Pantoş, P Shirude and S Balasubramanian
Chem. Eur. J., 2012, 18, 554 – 64
DOI: 10.1002/chem.201102556
Decoding genomes at high speed: implications for science and medicine
S Balasubramanian
Angew. Chem. Int. Ed., 2011, 50, 12406 – 12410
DOI: 10.1002/anie.201106707
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands
D Koirala, S Dhakal, B Ashbridge, Y Sannohe, R Rodriguez, H Sugiyama, S Balasubramanian and H Mao
Nature Chemistry, 2011, 3, 782 – 787
DOI: 10.1038/nchem.1126
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton
N S Hegde, D A Sanders, R Rodriguez and S Balasubramanian
Nature Chemistry, 2011, 3, 725 – 731
DOI: 10.1038/nchem.1114
A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing
H L Lightfoot, A Bugaut, J Armisen, N J Lehrbach, E A Miska and S Balasubramanian
Biochemistry, 2011, 50, 7514 – 7521
DOI: 10.1021/bi200851d
A Sequence-Independent Analysis of the Loop Length Dependence of Intramolecular RNA G-Quadruplex Stability and Topology
A Zhang, A Bugaut and S Balasubramanian
Biochemistry, 2011, 50, 7251 – 7258
DOI: 10.1021/bi200805j
Sequencing nucleic acids: from chemistry to medicine
S Balasubramanian
Chem. Commun., 2011, 47, 7281 – 7286
DOI: 10.1039/c1cc11078k Highlight
Targeting G‐quadruplexes in gene promoters: a novel anticancer strategy?
S Balasubramanian, L H Hurley and S Neidle
Nature Reviews Drug Discovery, 2011, 10, 261 – 275
DOI: 10.1038/nrd3428
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
J S Smith, Q Chen, L A Yatsunyk, J M Nicoludis, M S Garcia, R Kranaster, S Balasubramanian, D Monchaud, M Teulade-Fichou, L Abramowitz, D C Schultz and F B Johnson
Nature Structural & Molecular Biology, 2011, 18, 478 – 485
DOI: 10.1038/nsmb.2033
Synthesis and Binding Studies of Novel Diethynyl-pyridine Amides with Genomic Promoter DNA G-quadruplexes
J Dash, Z A E Waller, G D Pantos and S Balasubramanian
Chem. Eur. J., 2011, 17, 4571 – 4581
DOI: 10.1002/chem.201003157
G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells
K I E McLuckie, Z A E Waller, D A Sanders, D Alves, R Rodriguez, J Dash, G J McKenzie, A R Venkitaraman and S Balasubramanian
J. Am. Chem. Soc., 2011, 133, 2658 – 2663
DOI: 10.1021/ja109474c
