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240

A Photo‐responsive Small‐Molecule Approach for the Opto‐epigenetic Modulation of DNA Methylation
H P Nguyen, S Stewart, M N Kukwikila, S F Jones, D Offenbartl-Stiegert, S Mao, S Balasubramanian, S Beck and S Howorka
Angew. Chem. Int. Ed., 2019, 58, 6620-6624
DOI: 10.1002/anie.201901139
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239

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylations
L Pandolfini, I Barbieri, A Bannister, A Hendrick, B Andrews, N Webster, P Murat, P Mach, R Brandi, S Robson, V Migliori, A Alendar, M d’Onofrio, S Balasubramanian and T Kouzarides
Molecular Cell, 2019, 74, 1-13
DOI: 10.1016/j.molcel.2019.03.040
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238

Detection, Structure and Function of Modified DNA Bases
A Hofer, Z Liu, S Balasubramanian
J. Am. Chem. Soc., 2019, 141, 16, 6420-6429
DOI: 10.1021/jacs.9b01915
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237

Whole genome experimental maps of DNA G-quadruplexes in multiple species
G Marsico, V S Chambers, A B Sahakyan, P McCauley, J M Boutell, M Di Antonio, S Balasubramanian
Nucleic Acids Research, 2019, 47:8, 3862-3874
DOI: 10.1093/nar/gkz179
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236

Structure of (3+1) hybrid G-quadruplex in the PARP1 promoter
A Sengar, J J Vandana, V S Chambers, M Di Antonio, F R Winnerdy, S Balasubramanian, A T Phan
Nucleic Acids Research, 2018, 47:3, 1564–1572
DOI: 10.1093/nar/gky1179
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235

RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs
P Murat, G Marsico, B Herdy, A Ghanbarian, G Portella and S Balasubramanian
Genome Biology, 2018, 9:229
DOI: 10.1186/s13059-018-1602-2
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234

5-Formylcytosine organises nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells
E-A Raiber, G Portella, S Martinez Cuesta, R Hardisty, P Murat, Z Li, M Iurlaro, W Dean, J Spindel, D Beraldi, Z Liu, M Dawson, W Reik and S Balasubramanian
Nature Chemistry, 2018, 10, 1258–1266
DOI: 10.1038/s41557-018-0149-x
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233

DNA G-quadruplex structures mold the DNA methylome
S-Q Mao, A T Ghanbarian, J Spiegel, S Martinez Cuesta, D Beraldi, M Di Antonio, G Marsico, R Hansel-Hertsch, D Tannahill and S Balasubramanian
Nature Structural & Molecular Biology2018, 25, 951–957
DOI: 10.1038/s41594-018-0131-8
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232

Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts
B Herdy, C Mayer, D Varshney, G Marsico, P Murat, C Taylor, C D’Santos, D Tannahill and S Balasubramanian
Nucleic Acids Research2018, 46:21, 11592–11604
DOI: 10.1093/nar/gky861
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231

Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome
C K Kwok, G Marsico, S Balasubramanian
Cold Spring Harb. Prospect. Biol.2018, 10:a032284
DOI: 10.1101/cshperspect.a032284
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230

Sequencing 5‐Hydroxymethyluracil at Single‐Base Resolution
F Kawasaki, S Martinez Cuesta, D Beraldi, A Mahtey, R Hardisty, M Carrington, S Balasubramanian
Angew. Chem. Int. Ed.2018, 57 (31), 9694-9696
DOI: 10.1002/anie.201804046
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229

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36
M C Chen, R Tippana, N A Demeshkina, P Murat, S Balasubramanian, S Myong and A R Ferré-D’Amaré
Nature2018, 558, 465–469
DOI: 10.1038/s41586-018-0209-9
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228

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
A Parry, M Hoare, D Bihary, R Hansel-Hertsch, S Smith, K Tomimatsu, E Mannion, A Smith, P D’Santos, A Russell,  S Balasubramanian, H Kimura, S Samarajiwa and M Narita
Nature Communications2018, 9, 1840
DOI: 10.1038/s41467-018-04283-9
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227

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing
R Hansel-Hertsch, J Spiegel, G Marsico, D Tannahill and S Balasubramanian
Nature Protocols2018, 13, 551-564
DOI: 10.1038/nprot.2017.150
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226

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule
C Marchetti, K G Zyner, S A Ohnmacht, M Robson, S M Haider, J P Morton, G Marsico, T Vo, S Laughlin-Toth, A A Ahmed, G Di Vita, I Pazitna, M Gunaratnam, R J Besser, A C G Andrade, S Diocou, J A Pike, D Tannahill, R B Pedley, T R J Evans, W D Wilson, S Balasubramanian and S Neidle
J. Med. Chem.2018, 61 (6), 2500–2517
DOI: 10.1021/acs.jmedchem.7b01781
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225

Machine learning model for sequence-driven DNA G-quadruplex formation
A Sahakyan, V S Chambers, G Marsico, T Santner, M Di Antonio and S Balasubramanian
Scientific Reports2017, 7, 14535
DOI: 10.1038/s41598-017-14017-4
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224

DNA sequencing at 40: past, present and future
J Shendure, S Balasubramanian, G M Church, W Gilbert, J Rogers, J A Schloss and R H Waterson
Nature2017, 550, 345-353
DOI: 10.1038/nature24286
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223

Therapeutics: Click and discover
G Vassiliou and S Balasubramanian
Nature2017, 548, 162-164
DOI: 10.1038/548162a
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222

Synthesis and multiple incorporations of 2′-O-methyl-5-hydroxymethyl-, 5-hydroxymethyl- and 5-formylcytidine monomers into RNA oligonucleotides
A Tanpure and S Balasubramanian
ChemBioChem2017, 18, 2236 –2241
DOI: 10.1002/cbic.201700492
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221

Mapping and elucidating the function of modified bases in DNA
E-A Raiber, R Hardisty, P van Delft and S Balasubramanian
Nature Review Chemistry2017, 1, 0069
DOI: 10.1038/s41570-017-0069
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220

Local epigenetic reprogramming induced by G-quadruplex ligands
G Guilbaud, P Murat, B Recolin, B Campbell, A Maiter, J E Sale and S Balasubramanian
Nature Chemistry2017, 9, 1110-1117
DOI: 10.1038/nchem.2828
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219

The profile and dynamics of RNA modifications in animals
P Van Delft, A Akay, S M Huber, C Bueschl, K L M Rudolph, T Di Domenico, R Schuhmacher, E A Miska and S Balasubramanian
ChemBioChem2017, 18, 979-984
DOI: 10.1002/cbic.201700093
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218

Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma
E-A Raiber, D Beraldi, S Martínez Cuesta, G R McInroy, Z Kingsbury, J Becq, T James, M Lopes, K Allinson, S Field, S Humphray, T Santarius, C Watts, D Bentley and S Balasubramanian
npj Genomic Medicine20172:6
DOI: 10.1038/s41525-017-0007-6
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217

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
R Hänsel-Hertsch, M Di Antonio and S Balasubramanian
Nature Reviews Molecular Cell Biology2017, 18, 279–284
DOI: 10.1038/nrm.2017.3
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216

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, N J O’Neil, N Dos Santos, J Silvester, V Wei, J Garcia, F Kabeer, D Lai, P Soriano, J Banáth, D S Chiu, D Yap, D D Le, F B Ye, A Zhang, K Thu, J Soong, S Lin, A Hsin Chin Tsai, T Osako, T Algara, D N Saunders, J Wong, J Xian, M B Bally, J D Brenton, G W Brown, S P Shah, D Cescon, T W Mak, C Caldas, P C Stirling, P Hieter, S Balasubramanian and S Aparicio
Nature Communications20178, 14432
DOI:10.1038/ncomms144328
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215

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming
I Milagre, T M Stubbs, M R King, J Spindel, F Santos, F Krueger, M Bachman, A Segonds-Pichon, S Balasubramanian, S R Andrews, W Dean and W Reik
Cell Reports201718:5, 1079–1089
DOI: 10.1016/j.celrep.2017.01.008
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214

Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania
F Kawasaki, D Beraldi, R E Hardisty, G R McInroy, P van Delft and S Balasubramanian
Genome Biology201718:23
DOI: 10.1186/s13059-017-1150-1
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213

G-quadruplex structures within the 3’-UTR of LINE-1 elements stimulate retrotransposition
A B Sahakyan, P Murat, C Mayer and S Balasubramanian
Nature Str. Mol. Biol.201724, 243–247
DOI: 10.1038/nsmb.3367
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212

2′-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA
S M Huber, P van Delft, A Tanpure, E A Miska and S Balasubramanian
J. Am. Chem. Soc.2017139 (5), 1766–1769
DOI: 10.1021/jacs.6b12180
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211

Single genome retrieval of context-dependent variability in mutation rates for human germline
A B Sahakyan and S Balasubramanian
BMC Genomics201718:81
DOI: 10.1186/s12864-016-3440-5
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210

Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides
F Kawasaki, P Murat, Z Li, T Santner and S Balasubramanian
Chem. Comm.2017, 53, 1389 – 1392
DOI: 10.1039/C6CC08670E
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209

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms
T A Horea, F von Meyenna, M Ravichandranc, M Bachman, G Ficz, D Oxley, F Santosa, S Balasubramanian, T P Jurkowskic, and W Reik
PNAS, 2016, 113:42, 12202-12207
DOI: 10.1073/pnas.1608679113
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208

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
H L Lightfoot, E A Miska and S Balasubramanian
Org. Biomol. Chem., 2016, 14, 10208-10216
DOI: 10.1039/c6ob01945e
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207

G-quadruplex structures mark human regulatory chromatin
R Hänsel-Hertsch, D Beraldi, S V Lensing, G Marsico, K Zyner, A Parry, M Di Antonio, J Pike, H Kimura, M Narita, D Tannahill and S Balasubramanian
Nature Genetics, 2016, 48, 1267-1272
DOI: 10.1038/ng.3662
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206

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
C K Kwok, G Marsico, A B Sahakyan, V S Chambers and S Balasubramanian
Nature Methods, 2016, 13, 841-844
DOI: 10.1038/nmeth.3965
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205

DSBCapture: in situ capture and sequencing of DNA breaks
S V Lensing, G Marsico, R Hänsel-Hertsch, E Y Lam, D Tannahill and S Balasubramanian
Nature Methods, 2016, 13, 855-857
DOI: 10.1038/nmeth.3960
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204

An Epigenetics-Inspired DNA-Based Data Storage System
C Mayer, G R McInroy, P Murat, P van Delft and S Balasubramanian
Angew. Chem. Int. Ed., 2016, 55:37, 11144-11148
DOI: 10.1002/anie.201605531
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203

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine
M Iurlaro, G R McInroy, H E Burgess, W Dean, E-A Raiber, M Bachman, D Beraldi, S Balasubramanian and W Reik
Genome Biology, 2016, 17:141
DOI: 10.1186/s13059-016-1001-5
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202

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA
C K Kwok, A Sahakyan and S Balasubramanian
Angew. Chem. Int. Ed., 2016, 55, 8958-8961
DOI: 10.1002/anie.201603562
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201

Enhanced Methylation Analysis by Recovery of Unsequenceable Fragments
G R McInroy, D Beraldi, E-A Raiber, K Modrzynska, P van Delft, O Billker and S Balasubramanian
PLoS ONE, 2016, 3: e)152322
DOI: 10.1371/journal.pone.0152322
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200

Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases
A Sahakyan and S Balasubramanian
BMC Genomics, 2016, 17:225
DOI: 10.1186/s12864-016-2582-9
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199

Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes
O S Walker, S J Elsas̈ser, M Mahesh, M Bachman, S Balasubramanian and J W Chin
J. Am. Chem. Soc., 2016, 138, 718 – 721
DOI: 10.1021/jacs.5b07627
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198

Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies
S Patalano, A Vlasova, C Wyatt, P Ewels, F Camara, P G Ferreira, C L Asher, T P Jurkowski, A Segonds-Pichon, M Bachman, I González-Navarrete, A E Minoche, F Krueger, E Lowy, M Marcet-Houben, J L Rodriguez-Ales, F S Nascimento, S Balasubramanian, T Gabaldon, J E Tarver, S Andrews, H Himmelbauer, W O H Hughes, R Guigó, W Reik, and S Sumner
PNAS, 2016, 112, 13970 – 13975
DOI: 10.1073/pnas.1515937112
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197

High-throughput sequencing of DNA G-quadruplex structures in the human genome
V S Chambers, G Marsico, J M Boutell, M Di Antonio, G P Smith and S Balasubramanian
Nature Biotechnology, 2015, 33, 877 – 881
DOI: 10.1038/nbt.3295
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196

FOXM1 binds directly to non-consensus sequences in the human genome
D A Sanders, M V Gormally, G Marsico, D Beraldi, D Tannahill and S Balasubramanian
Genome Biology, 2015, 16:130
DOI: 10.1186/s13059-015-0696-z
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195

5-Formylcytosine can be a stable DNA modification in mammals
M Bachman, S Uribe-Lewis, X Yang, H E Burgess, M Iurlaro, W Reik and S Balasubramanian
Nature Chemical Biology, 2015, 11, 555 – 557
DOI: 10.1038/nchembio.1848
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194

Selective Chemical Labeling of Natural T Modifications in DNA
R E Hardisty, F Kawasaki, A B Sahakyan and S Balasubramanian
J. Am. Chem. Soc., 2015, 137, 9270 – 9272
DOI: 10.1021/jacs.5b03730
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193

Targeted detection of G-quadruplexes in cellular RNAs
C K Kwok and S Balasubramanian
Angew. Chem. Int. Ed., 2015, 54, 6751 – 6754
DOI: 10.1002/anie.201500891
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192

G-quadruplex ligands exhibit differential G-tetrad selectivity
D D Le, M Di Antonio, L K M Chan, and S Balasubramanian
Chem. Commun., 2015, 51, 8048 – 8050
DOI: 10.1039/C5CC02252E
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191

Chemical Methods for Decoding Cytosine Modifications in DNA
M J Booth, E-A Raiber, and S Balasubramanian
Chem. Rev., 2015, 115, 2240 – 2254
DOI: 10.1021/cr5002904
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190

Accurate Measurement of 5-Methylcytosine and 5-Hydroxymethylcytosine in Human Cerebellum DNA by Oxidative Bisulfite on an Array (OxBS-Array)
S F Field, D Beraldi, M Bachman, S K Stewart, S Beck, and S Balasubramanian
PloS ONE, 2015, 10:e0118202t
DOI: 10.1371/journal.pone.0118202
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189

Formation and Abundance of 5-Hydroxymethylcytosine in RNA
S M Huber, P van Delft, L Mendil, M Bachman, K Smollett, F Werner, E A Miska and S Balasubramanian
ChemBioChem., 2015, 16, 752 – 755
DOI: 10.1002/cbic.201500013
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188

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase
M C Chen, P Murat, K Abecassis, A R Ferre-D’Amare and S Balasubramanian
Nucleic Acids Res., 2015, 43, 2223 – 2231
DOI: 10.1093/nar/gkv051
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187

Decoding Genomes
S Balasubramanian
Biochem. Soc. Trans., 2015, 43, 1 – 5
DOI: 10.1042/BST20140254
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186

5-Formylcytosine alters the structure of the DNA double helix
E Raiber, P Murat, D Y Chirgadze, D Beraldi, B F Luisi and S Balasubramanian
Nature Structural & Molecular Biology, 2015, 22, 44 – 49
DOI: 10.1038/nsmb.2936
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185

Dual binding of an antibody and a small molecule increases the stability of the TERRA G-quadruplex
P M Yangyuoru, M Di Antonio, C Ghimire, G Biffi, S Balasubramanian, and H Mao
Angew. Chem. Int. Ed., 2015, 54, 910 – 913
DOI: 10.1002/anie.201408113
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184

oxBS-450K: A method for analysing hydroxymethylation using 450K BeadChips
S K Stewart, T J Morris, P Guilhamon, H Bulstrode, M Bachman, S Balasubramanian and S Beck
Methods, 2015, 72, 9 – 15
DOI: 10.1016/j.ymeth.2014.08.009
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183

Solexa Sequencing: Decoding Genomes on a Population Scale
S Balasubramanian
Clin. Chem., 2015, 61, 21 – 24
DOI: 10.1373/clinchem.2014.221747
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182

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition
M V Gormally, T S Dexheimer, G Marsico, D A Sanders, C Lowe, D Matak-Vinković, S Michael, A Jadhav, G Rai, D J Maloney, A Simeonov and S Balasubramanian
Nature Communications, 2014, 5:5165
DOI: 10.1038/ncomms6165
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181

Targeting DNA G-Quadruplexes with Helical Small Molecules
S Müller, K Laxmi-Reddy, PV Jena, B Baptiste, Z Dong, F Godde, T Ha, R Rodriguez, S Balasubramanian and I Huc
Chembiochem., 2014, 15, 2563 – 2570
DOI: 10.1002/cbic.201402439
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180

Nucleotide contributions to the structural integrity and DNA replication initiation activity of noncoding Y RNA
I Wang, M P Kowalski, A R Langley, R Rodriguez, S Balasubramanian, S T Hsu, and T Krude
Biochemistry, 2014, 53, 5848 – 5863
DOI: 10.1021/bi500470b
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179

5-Hydroxymethylcytosine is a predominantly stable DNA modification
M Bachman, S Uribe-Lewis, X Yang, M Williams, A Murrell and S Balasubramanian
Nature Chemistry, 2014, 6, 1049 – 1055
DOI: 10.1038/nchem.2064
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178

Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells
D Schiavone, G Guilbaud, P Murat, C Papadopoulou, P Sarkies, M Prioleau, S Balasubramanian and J E Sale
The EMBO Journal, 2014, 33, 2507 – 2520
DOI: 10.15252/embj.201488398
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177

Chemical biology on genomic DNA: minimizing PCR bias
G McInroy, E Raiber, and S Balasubramanian
Chem. Commun., 2014, 50, 12047 – 12049
DOI: 10.1039/C4CC05107F
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176

Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer
G Biffi, D Tannahill, J Miller, W J Howat and S Balasubramanian
PLoS ONE, 2014, 9, e102711
DOI: 10.1371/journal.pone.0102711
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175

Chemical Biology on the Genome
S Balasubramanian
Bioorg. Med. Chem.,2014, 22, 4356 – 4370
DOI: 10.1016/j.bmc.2014.05.016
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174

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand
M Di Antonio, K I E McLuckie, and S Balasubramanian
J. Am. Chem. Soc., 2014, 136, 5860 – 5863
DOI: 10.1021/ja5014344
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173

Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution
M J Booth, G Marsico, M Bachman, D Beraldi, and S Balasubramanian
Nature Chemistry, 2014, 6, 435 – 440
DOI: 10.1038/nchem.1893
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172

G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation
P Murat, J Zhong, L Lekieffre, N P Cowieson, J L Clancy, T Preiss, S Balasubramanian, R Khanna and J Tellam
Nature Chemical Biology, 2014, 10, 358 – 364
DOI: 10.1038/nchembio.1479
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171

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells
G Biffi, M Di Antonio, D Tannahill and S Balasubramanian
Nature Chemistry, 2014, 6, 75 – 80
DOI: 10.1038/nchem.1805
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170

Targeting a c-MYC G-quadruplex DNA with a fragment library
H R Nasiri, N Bell, K McLuckie, J Husby, C Abell, S Neidle and S Balasubramanian
Chem. Commun., 2014, 50, 1704 – 1707
DOI: 10.1039/C3CC48390H
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169

Existence and consequences of G-quadruplex structures in DNA
P Murat and S Balasubramanian
Curr. Opin. Genet. Dev., 2014, 25, 22 – 29
DOI: 10.1016/j.gde.2013.10.012
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168

The binding interaction between long non-coding RNA HOTAIR and PRC2 proteins
L Wu, P Murat, D Matak-Vinkovic, A Murrell and S Balasubramanian
Biochemistry, 2013, 52, 9519 – 9527
DOI: 10.1021/bi401085h
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167

Targeting RNA-Protein Interactions within the Human Immunodeficiency Virus Type 1 Lifecycle
N Bell, A L’Hernault, P Murat, J E Richards, A M Lever, and S Balasubramanian
Biochemistry, 2013, 52, 9269 – 9274
DOI: 10.1021/bi401270d
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166

Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes
P Yangyuoru, A Zhang, Z Shi, D Koirala, S Balasubramanian and H Mao
ChemBioChem., 2013, 14, 1931 – 1935.
DOI: 10.1002/cbic.201300350
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165

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
M Iurlaro, G Ficz, D Oxley, E Raiber, M Bachman, M J Booth, S Andrews, S Balasubramanian and W Reik
Genome Biology, 2013, 14:R119
DOI: 10.1186/gb-2013-14-10-r119
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164

Oxidative Bisulfite sequencing of 5-methylcytosine and 5-hydroxymethlcytosine
M J Booth, T W B Ost, D Beraldi, N Bell, M Branco, W Reik and S Balasubramanian
Nature Protocols, 2013, 8, 1841 – 1851
DOI: 10.1038/nprot.2013.115
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163

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
P Murat, M V Gormally, D Sanders, M Di Antonio and S Balasubramanian
Chem. Commun., 2013, 49, 8453 – 8455
DOI: 10.1039/C3CC44737E
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162

G-quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells
K I E McLuckie, M Di Antonio, H Zecchini, J Xian, C Caldas, B F Krippendorff, D Tannahill, C Lowe and S Balasubramanian
J. Am. Chem. Soc., 2013, 135, 9640 – 9643
DOI: 10.1021/ja404868t
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161

G-quadruplex structures are stable and detectable in human genomic DNA
E Yi Ni Lam, D Beraldi, D Tannahill and S Balasubramanian
Nature Communications, 2013, 4, 1796
DOI: 10.1038/ncomms2792
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160

Down-regulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer
T Mitchell, A Ramos-Montoya, M Di Antonio, P Murat, S Ohnmacht, M Micco, S Jurmeister, L Fryer, S Balasubramanian, S Neidle and D E Neal
Biochemistry, 2013, 52, 1429 – 1436
DOI: 10.1021/bi301349c
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159

Genome-wide mapping of FOXM1 binding reveals co binding with estrogen receptor alpha in breast cancer cells
D A Sanders, C S Ross-Innes, D Beraldi, J S Carroll and S Balasubramanian
Genome Biology, 2013, 14:R6
DOI: 10.1186/gb-2013-14-1-r6
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158

Quantitative visualization of DNA G-quadruplex structures in human cells
G Biffi, D Tannahill, J McCafferty and S Balasubramanian
Nature Chemistry, 2013, 5, 182 – 186
DOI: 10.1038/nchem.1548
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157

An Acetylene-Bridged 6,8-Purine Dimer as a Fluorescent Switch-On Probe for Parallel G-Quadruplexes
M Nikan, M Di Antonio, K Abecassis, K McLuckie and S Balasubramanian
Angew. Chem. Int. Ed. , 2013, 52, 1428 – 1431
DOI: 10.1002/anie.201207075
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156

An RNA Hairpin to G-Quadruplex Conformational Transition
A Bugaut, P Murat and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 19953 – 19956
DOI: 10.1021/ja308665g
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155

The Kinetics and Folding Pathways of Intramolecular G-Quadruplex Nucleic Acids
A Zhang and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 19297 – 19308
DOI: 10.1021/ja309851t
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154

Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry
M Di Antonio, G Biffi, A Mariani, E-A Raiber, R Rodriguez and S Balasubramanian
Angew. Chem. Int. Ed, 2012, 51, 11073 – 11078
DOI: 10.1002/anie.201206281
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153

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
S Müller, D A Sanders, M Di Antonio, S Matsis, J F Riou, R Rodriguez and S Balasubramanian
Org. Biomol. Chem., 2012, 10, 6537 – 6546
DOI: 10.1039/C2OB25830G
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152

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase
E-A Raiber, D Beraldi, G Ficz, H Burgess, M R Branco, P Murat, D Oxley, M J Booth, W Reik and S Balasubramanian
Genome Biology, 2012, 13:R69
DOI: 10.1186/gb-2012-13-8-r69
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151

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2
G Biffi, D Tannahill and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 11974 – 11976
DOI: 10.1021/ja305734x
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150

50-UTR RNA G-quadruplexes: translation regulation and targeting
A Bugaut and S Balasubramanian
Nucleic Acids Res., 2012, 40, 4727 – 4741
DOI: 10.1093/nar/gks068
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149

Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution
M J Booth, M R Branco, G Ficz, D Oxley, F Krueger, W Reik and S Balasubramanian
Science, 2012, 336, 934 – 937
DOI: 10.1126/science.1220671
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148

Experimental Approaches to Identify Cellular G-quadruplex Structures and Functions
M Di Antonio, R Rodriguez and S Balasubramanian
Methods, 2012, 57, 84 – 92
DOI: 10.1016/j.ymeth.2012.01.008
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147

Comparative Structural Effects of HIV-1 Gag and Nucleocapsid Proteins in Binding to and Unwinding of the Viral RNA Packaging Signal
N M Bell, J C Kenyon, S Balasubramanian and A M L Lever
Biochemistry, 2012, 51, 3162 – 3169
DOI: 10.1093/nar/gks068
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146

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
R Rodriguez, K M Miller, J V Forment, C R Bradshaw, M Nikan, S Britton, T Oelschlaegel, B Xhemalce, S Balasubramanian and S P Jackson
Nature Chemical Biology, 2012, 8, 301 – 310
DOI: 10.1038/nchembio.780
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145

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
P Sarkies, P Murat, L G Phillips, K J Patel, S Balasubramanian and J E Sale
Nucleic Acids Res., 2012, 40, 1485 – 1498
DOI: 10.1093/nar/gkr868
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144

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
E-A Raiber, R Kranaster, E Lam, M Nikan and S Balasubramanian
Nucleic Acids Res., 2012, 40, 1499 – 1508
DOI: 10.1093/nar/gkr882
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143

Demonstration of Ligand Decoration, and Ligand-Induced Perturbation, of G-Quadruplexes in a Plasmid Using Atomic Force Microscopy
I Mela, R Kranaster, R M Henderso, S Balasubramanian and J M Edwardson
Biochemistry, 2012, 51, 578 – 585
DOI: 10.1021/bi201600g
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142

Synthesis of Bis-indole Carboxamides as G-Quadruplex Stabilizing and Inducing Ligands
J Dash, R N Das, N Hegde, G D Pantoş, P Shirude and S Balasubramanian
Chem. Eur. J., 2012, 18, 554 – 64
DOI: 10.1002/chem.201102556
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141

Decoding genomes at high speed: implications for science and medicine
S Balasubramanian
Angew. Chem. Int. Ed., 2011, 50, 12406 – 12410
DOI: 10.1002/anie.201106707
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140

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands
D Koirala, S Dhakal, B Ashbridge, Y Sannohe, R Rodriguez, H Sugiyama, S Balasubramanian and H Mao
Nature Chemistry, 2011, 3, 782 – 787
DOI: 10.1038/nchem.1126
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139

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton
N S Hegde, D A Sanders, R Rodriguez and S Balasubramanian
Nature Chemistry, 2011, 3, 725 – 731
DOI: 10.1038/nchem.1114
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138

A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing
H L Lightfoot, A Bugaut, J Armisen, N J Lehrbach, E A Miska and S Balasubramanian
Biochemistry, 2011, 50, 7514 – 7521
DOI: 10.1021/bi200851d
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137

A Sequence-Independent Analysis of the Loop Length Dependence of Intramolecular RNA G-Quadruplex Stability and Topology
A Zhang, A Bugaut and S Balasubramanian
Biochemistry, 2011, 50, 7251 – 7258
DOI: 10.1021/bi200805j
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136

Sequencing nucleic acids: from chemistry to medicine
S Balasubramanian
Chem. Commun., 2011, 47, 7281 – 7286
DOI: 10.1039/c1cc11078k Highlight
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135

Targeting G‐quadruplexes in gene promoters: a novel anticancer strategy?
S Balasubramanian, L H Hurley and S Neidle
Nature Reviews Drug Discovery, 2011, 10, 261 – 275
DOI: 10.1038/nrd3428
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134

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
J S Smith, Q Chen, L A Yatsunyk, J M Nicoludis, M S Garcia, R Kranaster, S Balasubramanian, D Monchaud, M Teulade-Fichou, L Abramowitz, D C Schultz and F B Johnson
Nature Structural & Molecular Biology, 2011, 18, 478 – 485
DOI: 10.1038/nsmb.2033
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133

Synthesis and Binding Studies of Novel Diethynyl-pyridine Amides with Genomic Promoter DNA G-quadruplexes
J Dash, Z A E Waller, G D Pantos and S Balasubramanian
Chem. Eur. J., 2011, 17, 4571 – 4581
DOI: 10.1002/chem.201003157
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132

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells
K I E McLuckie, Z A E Waller, D A Sanders, D Alves, R Rodriguez, J Dash, G J McKenzie, A R Venkitaraman and S Balasubramanian
J. Am. Chem. Soc., 2011, 133, 2658 – 2663
DOI: 10.1021/ja109474c
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131

Small-molecule-mediated G-quadruplex isolation from human cells
S Müller, S Kumari, R Rodriguez and S Balasubramanian
Nature Chemistry, 2010, 2, 1095 – 1098
DOI: 10.1038/NCHEM.842
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130

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
M Bejugam, M Gunaratnam, S Müller, D A Sanders, S Sewitz, J A Fletcher, S Neidle and S Balasubramanian
ACS Med. Chem. Lett., 2010, 1, 306 – 310
DOI: 10.1021/ml100062z
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129

Distinct functions of maternal and somatic Pat1 protein paralogs
A Marnef, M Maldonado, A Bugaut, S Balasubramanian, M Kress, D Weil and N Standart
RNA, 2010, 16, 2094 – 2107
DOI: 10.1261/rna.2295410
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128

The BCL-2 5′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif that Modulates Protein Expression
R Shahid, A Bugaut and S Balasubramanian
Biochemistry, 2010, 49, 8300 – 8306
DOI: 10.1021/bi100957h
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127

Small Molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
A Bugaut, R Rodriguez, S-T D Hsu and S Balasubramanian
Org. Biomol. Chem., 2010, 8, 2771 – 2776
DOI: 10.1039/c002418j
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126

RNA Conformation in Catalytically Active Human Telomerase
J A Yeoman, A Orte, B Ashbridge, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2010, 132, 2852 – 2853
DOI: 10.1021/ja909383n
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125

Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes
A Fegan, P S Shirude, L Ying and S Balasubramanian
Chem. Commun., 2010, 46, 946 – 948
DOI: 10.1039/b920680a
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124

Single-Molecule Analysis of the Human Telomerase RNA·Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations
B Ashbridge, A Orte, J A Yeoman, M Kirwan, T Vulliamy, I Dokal, D Klenerman and S Balasubramanian
Biochemistry, 2009, 48, 10858 – 10865
DOI: 10.1021/bi901373e
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123

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
H Fernando, S Sewitz, J Darot, S Tavaré, J L Huppert and S Balasubramanian
Nucleic Acids Research, 2009, 37, 6716 – 6722
DOI: 10.1093/nar/gkp740
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122

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
N J Lehrbach, J Armisen, H L Lightfoot, K J Murfitt, A Bugaut, S Balasubramanian and E A Miska
Nature Structural & Molecular Biology, 2009, 16, 1016 – 1020
DOI:10.1038/nsmb.1675
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121

A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
S-T Hsu, P Varnai, A Bugaut, A P Reszka, S Neidle and S Balasubramanian
J. Am. Chem. Soc., 2009, 131, 13399 – 13409
DOI: 10.1021/ja904007p
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120

G-quadruplex DNA bound by a synthetic ligand is highly dynamic
P V Jena, P S Shirude, B Okumus, K Laxmi-Reddy, F Godde, I Huc, S Balasubramanian and T Ha
J. Am. Chem. Soc., 2009, 131, 12522 – 12523
DOI: 10.1021/ja903408r
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119

A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
Z A E Waller, S A Sewitz, S-T Hsu and S Balasubramanian
J. Am. Chem. Soc., 2009, 131, 12628 – 12633
DOI: 10.1021/ja901892u
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118

G-quadruplex nucleic acids as therapeutic targets
S Balasubramanian and S Neidle
Curr. Opin. Chem. Bio., 2009, 13, 345 – 353
DOI: 10.1016/j.cbpa.2009.04.637
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117

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition
S Müller, G Dan Pantos, R Rodriguez and S Balasubramanian
Chem. Commun., 2009, 80 – 82
DOI: 10.1039/B816861J
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116

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
J E Redman, J M Granadino-Roldán, J A Schouten, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2009, 7, 76 – 84
DOI: 10.1039/b814682a
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115

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
T B C London, L J Barber, G Mosedale, G P Kelly, S Balasubramanian, I D Hickson, S J Boulton and K Hiom
J. Biol. Chem., 2008, 283, 36132 – 36139
DOI: 10.1074/jbc.M808152200
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114

Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of the NRAS Proto-oncogene
S Kumari, A Bugaut and S Balasubramanian
Biochemistry, 2008, 47, 12664 – 12669
DOI: 10.1021/bi8010797
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113

Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes
J Dash, P S Shirude, S-T D Hsu and S Balasubramanian
J. Am. Chem. Soc., 2008, 130, 15950 – 15956
DOI: 10.1021/ja8046552
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112

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
R Rodriguez, S Müller, J A Yeoman, C Trentesaux, J-F Riou and S Balasubramanian
J. Am. Chem. Soc., 2008, 130, 15758 – 15759
DOI: 10.1021/ja805615w
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111

Accurate whole human genome sequencing using reversible terminator chemistry
D R Bentley, S Balasubramanian, H P Swerdlow et al.
Nature, 2008, 456, 53 – 59
DOI: 10.1038/nature07517
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110

G-quadruplexes: the beginning and end of UTRs
J L Huppert, A Bugaut, S Kumari and S Balasubramanian
Nucleic Acids Res., 2008, 36, 6260 – 6268
DOI: 10.1093/nar/gkn511
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109

Selective Recognition of a DNA G-Quadruplex by an Engineered Antibody
H Fernando, R Rodriguez and S Balasubramanian
Biochemistry, 2008, 47, 9365 – 9371
DOI: 10.1021/bi800983u
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108

Single molecule conformational analysis of DNA G-quadruplexes
P S Shirude and S Balasubramanian
Biochimie, 2008, 90, 1197 – 1206
DOI: 10.1039/b801465e
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107

G-quadruplex recognition by bis-indole carboxamides
J Dash, P S Shirude and S Balasubramanian
Chem. Commun., 2008, 3055 – 3057
DOI: 10.1039/b806042h
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106

Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC
P S Shirude, L Ying and S Balasubramanian
Chem. Commun., 2008, 2007 – 2009
DOI: 10.1039/b801465e
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105

Rigid cyanine dye nucleic acid labels
A Fegan, P S Shirude and S Balasubramanian
Chem. Commun., 2008, 2004 – 2006
DOI: 10.1039/b801629a
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104

Single-molecule analysis of human telomerase monomer
D Alves, H Li, R Codrington, A Orte, X Ren, D Klenerman and S Balasubramanian
Nature Chemical Biology, 2008, 4, 287 – 289
DOI: 10.1038/nchembio.82
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103

Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry
A Bugaut, K Jantos, J-L Wietor, R Rodriguez, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 2008, 47, 2677 – 2680
DOI: 10.1002/anie.200705589
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102

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition
Z A E Waller, P Shirude, R Rodriguez and S Balasubramanian
Chem. Commun., 2008, 1467 – 1469
DOI: 10.1039/b718854d
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101

A Sequence-Independent Study of the Influence of Short Loop Lengths on the Stability and Topology of Intramolecular DNA G-Quadruplexes
A Bugaut and S Balasubramanian
Biochemistry, 2008, 47, 689 – 697
DOI: 10.1021/bi701873c
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100

Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression
M Bejugam, S Sewitz, S P Shirude, R Rodriquez, R Shahid and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 12926 – 12927
DOI: 10.1021/ja075881p
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99

Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands
P S Shirude, E R Gillies, S Ladame, F Godde, K Shin-ya, I Huc and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 11890 – 11891
DOI: 10.1021/ja073775h
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98

Ligand-Driven G-Quadruplex Conformational Switching By Using an Unusual Mode of Interaction
R Rodriguez, G Dan Pantos, D P N Goncalves, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 2007, 46, 5404 – 5407
DOI: 10.1002/anie.200605075
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97

Single-Molecule Conformational Analysis of G-Quadruplex Formation in the Promoter DNA Duplex of the Proto-Oncogene C-Kit
P S Shirude, B Okumus, L Ying, T Ha and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 7484 – 7485
DOI: 10.1021/ja070497d
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96

An RNA G-quadruplex in the 5 UTR of the NRAS proto-oncogene modulates translation
S Kumari, A Bugaut, J L Huppert and S Balasubramanian
Nature Chemical Biology, 2007, 3, 218 – 221
DOI: 10.1038/nchembio864
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95

G-quadruplexes in promoters throughout the human genome
J L Huppert and S Balasubramanian
Nucleic Acids Res., 2007, 35, 2, 406 – 413
DOI: 10.1093/nar/gkm109
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94

Tetramethylpryidiniumporphyrazines – a new class of G-quadruplex inducing and stabilising ligands
D P Goncalves, R Rodriguez, S Balasubramanian and J K M Sanders
Chem. Commun., 2006, 4685 – 4687
DOI: 10.1039/b611731g
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93

Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
J E Redman, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2006, 4, 4364 – 4369
DOI: 10.1039/B611716C
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92

A Simple Nanomixer for Single-Molecule Kinetics Measurements
S S White, S Balasubramanian, D Klenerman and L Ying
Angew. Chem. Int. Ed., 2006, 45, 7540 – 7543
DOI: 10.1002/anie.200602289
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91

Determination of the Fraction and Stoichiometry of Femtomolar Levels of Biomolecular Complexes in an Excess of Monomer Using Single-Molecule, Two-Color Coincidence Detection
A Orte, R Clarke, S Balasubramanian and D Klenerman
Anal. Chem., 2006 78, 7707 – 7715
DOI: 10.1021/ac061122y
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90

Structural Analysis of the Catalytic Core of Human Telomerase RNA by FRET and Molecular Modeling
G Gavory, M F Symmons, Y Krishnan Ghosh, D Klenerman and S Balasubramanian
Biochemistry, 2006, 45, 13304 – 13311
DOI: 10.1021/bi061150a
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89

Oxazole-Based Peptide Macrocycles: A New Class of G-Quadruplex Binding Ligands
K Jantos, R Rodriguez, S Ladame, P S Shirude and S Balasubramanian
J. Am. Chem. Soc., 2006, 128, 13662 – 13663
DOI: 10.1021/ja064713e
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88

Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
D P N Goncalves, S Ladame, S Balasubramanian and J K M Sanders
Org. Biomol. Chem., 2006, 4, 3337 – 3342
DOI: 10.1039/b608494j
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87

Investigating a quadruplex-ligand interaction by unfolding kinetics
J J Green, S Ladame, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2006, 126, 9809 – 9812
DOI: 10.1021/ja0615425
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86

A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
H Fernando, A P Reszka, J Huppert, S Ladame, S Rankin, A R Venkitaraman, S Neidle and S Balasubramanian
Biochemistry, 2006, 45, 7854 – 7860
DOI: 10.1021/bi0601510
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85

Analysis of Human Telomerase Activity and Function by Two Color Single Molecule Coincidence Fluorescence Spectroscopy
X Ren, H Li, R W Clarke, D A Alves, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2006, 128, 4992 – 5000
DOI: 10.1021/ja056613z
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84

A Reversible pH-Driven DNA Nanoswitch Array
D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman and D Zhou
J. Am. Chem. Soc., 2006, 128, 2067 – 2071
DOI: 10.1021/ja0568300
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83

Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein
S Ladame, J A Schouten, J Roldan, J E Redman, S Neidle and S Balasubramanian
Biochemistry, 2006, 45, 1393 – 1399
DOI: 10.1021/bi050229x
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82

DNA molecular motor driven micromechanical cantilever arrays
W Shu, D Liu, M Watari, C K Riener, T Strunz, M E Welland, S Balasubramanian and R McKendry
J. Am. Chem. Soc., 2005, 127, 17054 – 17060
DOI: 10.1021/ja0554514
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81

PNA forms an i-motif
Y Krishnan-Ghosh, E Stephens and S Balasubramanian
Chem. Commun., 2005, 5278 – 5280
DOI: 10.1039/B510405J
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80

Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach
S Ladame, A Whitney and S Balasubramanian
Angew. Chem. Int. Ed., 2005, 44, 5736 – 5739
DOI: 10.1002/anie.200501450
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79

Putative DNA quadruplex formation within the human c-kit oncogene
S Rankin, A P Reszka, J Huppert, M Zloh, G N Parkinson, A K Todd, S Ladame, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 2005, 127, 10584 – 10589
DOI: 10.1021/ja050823u
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78

Dynamic covalent chemistry on self-templating PNA oligomers: formation of a bimolecular PNA quadruplex
Y Krishnan-Ghosh and S Balasubramanian
Chem. Commun., 2005, 3068 – 3070
DOI: 10.1039/B503578C
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77

Prevalence of quadruplexes in the human genome
J L Huppert and S Balasubramanian
Nucleic Acids Res., 2005, 33, 2908 – 2916
DOI: 10.1093/nar/gki609
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76

Solid-phase methods for the synthesis of cyanine dyes
S Mason, J Hake, J Nairne, E J Cummins and S Balasubramanian
J. Org. Chem., 2005, 70, 2939 – 2949
DOI: 10.1021/jo0479415
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75

Loop-length dependent folding of G-quadruplexes
P Hazel, J Huppert, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 2004, 126, 16405 – 16415
DOI: 10.1021/ja045154j
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74

Individual molecules of dye-labeled DNA act as a reversible two-colour switch upon application of an electric field
S S White, L Ying, S Balasubramanian and D Klenerman
Angew. Chem. Int. Ed., 2004, 43, 5926 – 5930
DOI: 10.1021/jp036715g
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73

Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
S D Patel, M Isalan, G Gavory, S Ladame, Y Choo and S Balasubramanian
Biochemistry, 2004, 43, 13452 – 13458
DOI: 10.1021/bi048892t
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72

Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform
S Ladame, J A Schouten, J Stuart, J Roldan, S Neidle and S Balasubramanian
Org. Biomol. Chem., 20042, 2925 – 2931
DOI: 10.1039/B409698C
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71

Measuring Single Molecule Nucleic Acid Dynamics in Solution by Two-Color Filtered Ratiometric Fluorescence Correlation Spectroscopy
H Li, X Ren, S Balasubramanian and D Klenerman
PNAS, 2004, 101, 14425 – 14430
DOI: 10.1073/pnas.0404295101
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70

Formation of an Interlocked Quadruplex Dimer by d(GGGT)
Y Krishnan-Ghosh, D Liu and S Balasubramanian
J. Am. Chem. Soc. , 2004, 125, 11009 – 11016
DOI: 10.1021/ja049259y
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69

Studies on the chemical stability and synthetic utility of an oxazolidine linker for solid-phase chemistry
A J Wills, M Cano and S Balasubramanian
J. Org. Chem., 2004, 69, 5439 – 47
DOI: 10.1021/jo049569z
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68

Molecule by molecule direct and quantitative counting of antibody complexes in solution
H Li, L Ying, S Balasubramanian and D Klenerman
Anal. Chem., 2004, 76, 4446 – 51
DOI: 10.1021/ac049512c
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67

A PNA4 Quadruplex
Y Krishnan-Ghosh, E Stephens and S Balasubramanian
J. Am. Chem. Soc., 2004, 126, 5944 – 5945
DOI: 10.1021/ja031508f
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66

Targeting the Single-Stranded Overhang of Telomeres with PNA Inhibits Cell Growth and Induces Apoptosis of Human Immortal Cells
M A Shammas, X Liu, G Gavory, K D Raney, S Balasubramanian and R J Shmookler Reis
Experimental Cell Research, 2004, 295, 204 – 214
DOI: 10.1016/j.yexcr.2004.01.003
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65

Templated Ligand Assembly using G-quadruplex DNA and Dynamic Covalent Chemistry
A Whitney, S Ladame and S Balasubramanian
Angew. Chem. Int. Ed., 2004, 43, 1143 – 1146
DOI: 10.1002/anie.200353069
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64

Studies on the Structure and Dynamics of the Human Telomeric Quadruplex by Single Molecule Fluorescence Resonance Energy Transfer
L Ying, J J Green, H Li, D Klenerman and S Balasubramanian
PNAS, 2003, 100, 14629 – 14634
DOI: 10.1073/pnas.2433350100
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63

A proton fuelled DNA nanomachine
D Liu and S Balasubramanian
Angew. Chem. Int. Ed., 2003, 42, 5734 – 5736
DOI: 10.1002/anie.200352402
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62

Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenital point mutation
X Ren, G Gavory, H Li, L Ying, D Klenerman and S Balasubramanian
Nucleic Acids Res., 2003, 31, 6509 – 6515
DOI: 10.1093/nar/gkg871
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61

From the combinatorial chemistry boom to polymer-supported parallel chemistry: established technologies for drug discovery
M Cano and S Balasubramanian
Drugs of the Future, 2003, 28, 659 – 678
DOI: 10.1002/chin.200446268
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60

Recent Developments in Linker Design and Application
A J Wills and S Balasubramanian
Curr. Op. Chem. Biol., 2003, 7, 346 – 352
DOI: 10.1016/S1367-5931(03)00035-8
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59

Dynamic Covalent Chemistry on Self-Templating Peptides: Formation of a Disulfide-linked β-Hairpin Mimic
Y Krishnan-Ghosh and S Balasubramanian
Angew. Chem. Int. Ed., 2003, 42, 2171 – 2173
DOI: 10.1002/anie.200250551
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58

G-Quadruplex-Specific Peptide-Hemicyanine Ligands by Partial Combinatorial Selection
J A Schouten, S Ladame, S J Mason, M A Cooper and S Balasubramanian
J. Am. Chem. Soc., 2003, 125, 5594 – 5595
DOI: 10.1021/ja029356w
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57

Kinetics of Unfolding the Human Telomeric DNA Quadruplex using a PNA Trap
J Green, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2003, 125, 3763 – 3767
DOI: 10.1021/ja029149w
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56

Ultrasensitive coincidence fluorescence detection of single DNA molecules
H Li, L Ying, J J Green, S Balasubramanian and D Klenerman
Anal. Chem., 2003, 75, 1664 – 1670
DOI: 10.1021/ac026367z
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55

Site-Specific Cleavage of Human Telomerase RNA using PNA-Neocuproine.Zn(II) derivatives
A Whitney, G Gavory and S Balasubramanian
Chem. Commun., 2003, 36 – 37
DOI: 10.1039/B210135A
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54

PNA and oligonucleoide inhibitors of human telomerase
G Gavory and S Balasubramanian
Telomerases, Telomeres and Cancer Eds., G Krupp and R Parwaresch 67-80, Landes Bioscience: Austin, 2003

53

Solid phase catch-activate and release synthesis of cyanine dyes
S J Mason and S Balasubramanian
Org. Lett., 2002, 4, 4261 – 62
DOI: 10.1021/ol026836j
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52

Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro
G Gavory, M Farrow and S Balasubramanian
Nucleic Acids Res., 2002, 30, 4470 – 4480
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51

Synthesis of a polymer supported oxazolidine aldehyde for asymmetric chemistry
A J Wills, Y Krishnan-Ghosh and S Balasubramanian
J. Org. Chem., 2002, 67, 6646 – 6652
DOI: 10.1021/jo0203239
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50

Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation
I Horsey, Y Krishnan-Ghosh and S Balasubramanian
Chem. Commun., 2002, 14, 1950 – 51
DOI: 10.1039/B206054J
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49

Solid phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates
S Ladame, R J Harrison, S Neidle and S Balasubramanian
Org. Lett., 2002, 4, 2509 – 2512
DOI: 10.1021/ol026130p
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48

Synthesis of diastereomerically pure 1,4,5-substituted-2-oxopiperazines on solid-phase
N M Khan, M Cano and S Balasubramanian
Tetrahedron Lett., 2002, 43, 2439 – 2443
DOI: 10.1016/S0040-4039(02)00268-X
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47

Practical synthesis of a dithiane protected 3′,5′-dialkyoxybenzoin photolabile safety-catch linker (BPSC) for solid phase organic synthesis
M Cano, M Ladlow and S Balasubramanian
J. Org. Chem., 2002, 67, 129 – 135
DOI: 10.1021/jo010703e
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46

Studies on the chemical stability and functional group compatibility of the Benzoin Photolabile Safety-catch (BPSC) linker using an analytical construct
M Cano, M Ladlow and S Balasubramanian
J. Comb. Chem., 2002, 4, 44 – 48
DOI: 10.1021/cc010040e
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45

Solid Phase Chemical Technologies for Combinatorial Chemistry
S Balasubramanian
J. Cell. Biochem. Suppl., 2001, 37, 28 – 33

44

Non-Arrhenius kinetics of a DNA Hairpin-Loop
L Ying, M I Wallace, S Balasubramanian and D Klenerman
PNAS, 2001, 98, 5584 – 5589
DOI: 10.1073/pnas.101523498
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43

Probing DNA surface attachment and local environment using single molecule spectroscopy
M A Osborne, C L Barnes, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2001, 105, 3120 – 3126
DOI: 10.1021/jp0038660
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42

Selection of Zinc Fingers that Bind Single-Stranded Telomeric DNA in the G-Quadruplex Conformation
M Isalan, S D Patel, S Balasubramanian and Y Choo
Biochemistry, 2001, 40, 830 – 836
DOI: 10.1021/bi001728v
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41

Exploring a Benzyloxyaniline Linker Utilizing Ceric Ammonium Nitrate (CAN) as a Cleavage Reagent: Solid-Phase Synthesis of N-Unsubstituted Beta-Lactams and Secondary Amides
K Gordon and S Balasubramanian
Org. Lett., 2001, 3, 53 – 56
DOI: 10.1021/ol006766l
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40

The science of chemical discovery: probing the unknown with new technologies
S Balasubramanian
Drug Discovery Today, 2000, 5, 533-534
DOI: 10.1016/S1359-6446(00)01582-8
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39

FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin Loop
M I Wallace, L Ying, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2000, 104, 11551 – 11555
DOI: 10.1021/jp001560n
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38

A stereoselective synthesis of 1,3,4-substituted -lactams from polymer-supported chiral oxazolidine aldehyde
K Gordon, M Bolger, N Khan and S Balasubramanian
Tetrahedron Lett., 2000, 41, 8621 – 8625
DOI: 10.1021/ol2020048
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37

Strategies for the synthesis of fluorescently labelled PNA
X Liu and S Balasubramanian
Tetrahedron Lett., 2000, 41, 6153 – 6156
DOI: 10.1016/S0040-4039(00)00996-5
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36

Single Molecule Analysis of DNA Immobilised on Microspheres
M A Osborne, W S Furey, D Klenerman and S Balasubramanian
Anal. Chem., 2000, 72, 3678 – 3681
DOI: 10.1021/ac000129r
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35

Ratiometric analysis of single-molecule fluorescence resonance energy transfer using logical combinations of threshold criteria: A study of 12-mer DNA
L Ying, M I Wallace, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2000, 104, 5171 – 5178
DOI: 10.1021/jp993914k
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34

Recent Developments in the Encoding and Deconvolution of Combinatorial Libraries
C L Barnes and S Balasubramanian
Curr. Opin. Chem. Bio., 2000, 4, 346 – 350
DOI: 10.1016/S1367-5931(00)00098-3
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33

Double Fluorescence Resonance Energy Transfer to Explore Multicomponent Binding Interactions: A Case Study of DNA Mismatches
I Horsey, W S Furey, J G Harrison, M A Osborne and S Balasubramanian
Chem. Commun., 2000, 12, 1043 – 1044
DOI: 10.1039/B002540M
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32

Solid-Phase Synthesis of N-Alkyl-N-(β-keto)amides and 1,2,4,5-Tetrasubstituted Imidazoles Using a Traceless Cleavage Strategy
H B Lee and S Balasubramanian
Org. Lett., 2000, 2, 323 – 326
DOI: 10.1021/ol991271l
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31

Screening for Oligonucleotide Binding Affinity by a Convenient Fluorescence Competition Assay
J G Harrison, X Liu and S Balasubramanian
Nucleic Acids Research, 1999, 27, e14
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30

Thermodynamic Melting Studies on Oligonucleotide-Peptide Conjugates
C Frier, J G Harrison and S Balasubramanian
Nucleosides and Nucleotides, 1999, 18, 1477 – 1478
DOI: 10.1080/07328319908044758
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29

Solid-phase synthesis: designer linkers for combinatorial chemistry
K Gordon and S Balasubramanian
J.Chem. Tech. Biotech., 1999, 74, 835 – 851
DOI: 10.1002/(SICI)1097-4660(199909)74:9<835::AID-JCTB130>3.0.CO;2-Z
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28

Recent advances in solid-phase chemical methodologies
K Gordon and S Balasubramanian
Current Opinion in Drug Discovery and Development, 1999, 2, 342 – 349
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27

Exploring a chemical encoding strategy for combinatorial synthesis using Friedels-Craft alkylation
R H Scott, C Barnes U Gerhard and S Balasubramanian
Chem. Commun., 1999, 1331-1332
DOI: 10.1039/A902489A
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26

Studies on Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid Phase Synthesis
H B Lee and S Balasubramanian

J. Org. Chem., 1999, 64, 3454 – 3460; 1999, 64, 5728 (legend correction)
DOI: 10.1021/jo981987e
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25

Inhibition of Human Telomerase by PNA- Cationic Peptide Conjugates
J G Harrison, C Frier, R Laurant, K D Raney and S Balasubramanian
Bioorg. Med. Chem. Lett., 1999, 9, 1273 – 1278
DOI: 10.1016/S0960-894X(99)00170-5
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24

Progress in Chemical Encoding for Combinatorial Synthesis

C Barnes, R H Scott and S Balasubramanian
Recent Res. Devel. in Organic Chem., 1998, 2, 367 – 379
DOI: 10.1002/chin.199946279
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23

Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates
J G Harrison and S Balasubramanian
Nucleic Acids Res., 1998, 26, 3136 – 3145
DOI: 10.1093/nar/26.13.3136
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22

Optically Biased Diffusion of Single Molecules Studied by Confocal Fluorescence Microscopy

M A Osbourne, S Balasubramanian, W S Furey and D Klenerman

J. Phys. Chem. B, 1998, 102, 3160 – 3167
DOI: 10.1021/jp9715078
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21

Use of Fluorescence Resonance Energy Transfer to Investigate the Conformation of DNA Substrates Bound to the Klenow Fragment
W S Furey, C M Joyce, M A Osbourne, D Klenerman, J A Peliska and S Balasubramanian
Biochemistry, 1998, 37, 2979 – 2990
DOI: 10.1021/bi9719758
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20

A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine peptide Library

Y W Cheung, C Abell and S Balasubramanian
J. Am. Chem. Soc., 1997, 119, 9568 – 9569
DOI: 10.1021/ja971825k
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19

Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids
M H Todd, S Balasubramanian and C Abell
Tetrahedron Lett., 1997, 38, 6781 – 6784
DOI: 10.1016/S0040-4039(97)01552-9
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18

Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support
V Arumugam, A Routledge, C Abell and S Balasubramanian
Tetrahedron Lett., 1997, 38, 6473 – 6476
DOI: 10.1016/S0040-4039(97)01481-0
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17

Properties of Fluorophores on Solid Phase Resins; Implications for Screening, Encoding and Reaction Monitoring
R H Scott and S Balasubramanian
Bioorg. Med. Chem. Lett., 1997, 7, 1567 – 1572
DOI: 10.1016/S0960-894X(97)00263-1
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16

A Convenient Synthetic Route to Oligonucleotide Conjugates
J G Harrison and S Balasubramanian
Bioorg. Med. Chem. Lett., 1997, 7, 1041 – 1046
DOI: 10.1016/S0960-894X(97)00152-2
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15

The Use of a Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis
A Routledge, C Abell and S Balasubramanian

Tetrahedron Lett., 1997, 38, 1227 – 1230
DOI: 10.1016/S0040-4039(96)02478-1
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14

An Investigation into Solid-Phase Radical Chemistry – Synthesis of Furan Rings

A Routledge, C Abell and S Balasubramanian

SynLett., 1997, 61 – 62
DOI: 10.1055/s-1997-704
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13

Solid Phase Reductive Alkylation of Secondary Amines
N K Khan, V Arumugam and S Balasubramanian
Tetrahedron Lett., 1996, 37, 4819 – 4822
DOI: 10.1016/0040-4039(96)00945-8
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12

Escherichia coli Chorismate Synthase Catalyses the Conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate

S Bornemann, M K Ramjee, S Balasubramanian, C Abell, J R Coggins, D J Lowe and R N F Thorneley
J. Biol. Chem., 1995, 270, 22811 – 22815
DOI: 10.1074/jbc.270.39.22811
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11

The Mechanism of Metal Independent Hydroxylation by Chromobacterium violaceum Phenylalanine Hydroxylase
R T Carr, S Balasubramanian, P Hawkins and S J Benkovic

Biochemistry, 1995, 34, 7525 – 7532
DOI: 10.1021/bi00022a028
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10

Escherichia coli Chorismate Synthase: A Deuterium Kinetic Isotope Effect Under Single Turnover and Steady State Conditions shows that a Flavin Intermediate forms before the C-(6proR)-H bond is cleaved
S Bornemann, S Balasubramanian, J R Coggins, C Abell, D J Lowe and R N F Thorneley

Biochem. J., 1995, 305, 707 – 710
DOI: 10.1042/bj3050707
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9

Observation of a Secondary Tritium Isotope Effect in the Reaction Catalyzed by Neurospora Crassa Chorismate Synthase
S Balasubramanian, J R Coggins and C Abell
Biochemistry, 1995, 34, 341 – 348
DOI: 10.1021/bi00001a042
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8

Recombinant HIV-1 Nucleocapsid Protein Accelerates HIV-1 Reverse Transcriptase Catalyzed DNA Strand Transfer Reactions and Modulates RNase H Activity

J A Peliska, S Balasubramanian, D P Giedroc and S J Benkovic
Biochemistry, 1994, 33, 13817 – 13823
DOI: 10.1021/bi00250a036
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7

Identification of Metal Ligands in Cu(II) Inhibited Chromobacterium violaceum Phenylalanine Hydroxylase by Electron Spin Echo Envelope Modulation Analysis of Histidine to Serine Mutations

S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic

Biochemistry, 1994, 33, 8532 – 8537
DOI: 10.1021/bi00194a019
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6

Studies on Escherichia coli Chorismate Synthase
S Borneman, M N Ramjee, D J Lowe, R N F Thorneley, J R Coggins, C Abell, S Balasubramanian, T R Hawkes, W W Nichols and G M Davies
Flavins and Flavoproteins, (Ed. K. Yagi) 843-846. Walter de Gruyer, Berlin, New York, 1994

5

Histidines 138 and 143 are Copper Binding Ligands in Chromobacterium violaceum Phenylalanine Hydroxylase
S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic
Chemistry and Biology of Pteridines and Folates, Eds. J.E. Ayling, M.G. Nair, and C.M. Baugh, 1993, 67 – 71
DOI: 10.1007/978-1-4615-2960-6_13
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4

Reaction of (6R)-6-F-EPSP with Recombinant Escherichia coli Chorismate Synthase Generates a Stable Flavin Mononucleotide Semiquinone Radical
M N Ramjee, S Balasubramanian, C Abell, J R Coggins, G M Davies, T R Hawkes, D J Lowe and R N F Thorneley
J. Am. Chem. Soc., 1992, 114, 3151 – 3153
DOI: 10.1021/ja00034a079
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3

Inhibition of Chorismate Synthase by (6R)- and (6S)-6-Fluoro-5-enolpyruvylshikimate 3-Phosphate

S Balasubramanian, G M Davies, J R Coggins and C Abell
J. Am. Chem. Soc., 1991, 113, 8945 – 8946
DOI: 10.1021/ja00023a051
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2

The Synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-Enolpyruvylshikimate 3-Phosphate
S Balasubramanian and C Abell
Tetrahedron Lett., 1991, 32, 963 – 966
DOI: 10.1016/S0040-4039(00)92131-2
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1

Observation of an Isotope Effect in the Chorismate Synthase Reaction
S Balasubramanian, C Abell and J R Coggins

J. Am. Chem. Soc., 1990, 112, 8581-858
DOI: 10.1021/ja00179a052
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