Research

Papers

272

An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription

Y Chen, A Simeone, L Melidis, S Martinez Cuesta, D Tannahill and S Balasubramanian
ACS Chem. Bill., 2024, early online publication
DOI: 10.1021/acschembio.3c00775

271

G-quadruplex DNA structure is a positive regulator of MYC transcription

I Esain-Garcia, A Kirchner, L Melidis, R de Cesaris Araujo Tavares, S Dhir, A Simeone, Z Yu, S K Madden, R Hermann, D Tannahill and S Balasubramanian
PNAS, 2024, 12 (7), e2320240121
DOI: 10.1073/pnas.2320240121

270

Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity

A Serrano-Benitez, S E Wells, L Drummond-Clarke, L C Russo, J C Thomas, G A Leal, M A Farrow, J M Edgerton, S Balasubramanian, M Yang, C Frezza, A Gautam, J Brazina, K Burdova, N C Hoch, S P Jackson and K W Caldecott
The EMBO Journal., 2023, e113190
DOI: 10.15252/embj.2022223190

269

A Photoredox Reaction for the Selective Modification of 5-Carboxycytosine in DNA

B J Mortishire-Smith, S M Becker, A Simeone, L Melidis and S Balasubramanian
J. Am. Chem. Soc., 2023, early online article
DOI: 10.1021/jacs.2c12558

268

Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis

M M Simpson, C C Lam, J M Goodman and S Balasubramanian
Angew. Chemie, 2023, e202304756
DOI: 10.1002/anie.202304756

267

Simultaneous sequencing of genetic and epigenetic bases in DNA

J Füllgrabe, W S Gosal, P Creed, S Liu, C K Lumby, D J Morley, T W B Ost, A J Vilella, S Yu, H Bignell, P Burns, T Charlesworth, B Fu, H Fordham, N J Harding, O Gandelman, P Golder, C Hodgson, M Li, M Lila, Y Liu, J Mason, J Mellad, J M Monahan, O Nentwich, A Palmer, M Steward, M Taipale, A Vandomme, R S San-Bento, A Singhal, J Vivian, N Wójtowicz, N Williams, N J Walker, N C H Wong, G N Yalloway, J D Holbrook and S Balasubramanian
Nature Biotechnology, 2023, early online article
DOI: 10.1038/s41587-022-01652-0

266

Chem-map profiles drug binding to chromatin in cells

Z Yu, J Spiegel, L Melidis, W W I Hui, X Zhang, A Radzevičius and S Balasubramanian
Nature Biotechnology, 2023, early online article
DOI: 10.1038/s41587-022-01636-0

265

Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

I C Navarro, K M Suen, D Bensaddek, A Tanpure, A Lamond, S Balasubramanian and E A Miska
Wellcome Open Res, 2022, 7:282
DOI: 10.12688/wellcomeopenres.17893.1

264

DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody

S Galli, L Melidis, S M Flynn, D Varshney, A Simeone, J Spiegel, S K Madden, D Tannahill and S Balasubramanian
Journal of the American Chemical Society, 2022, 144, 50, 23096–23103
DOI: 10.1021/jacs.2c10656#

263

Self-organization of plasticity and specialization in a primitively social insect

S Patalano, A Alsina, C Gregorio-Rodríguez, M Bachman, S Dreier, I Hernando-Herraez, P Nana, S Balasubramanian, S Sumner, W Reik and S Rulands
Cells Systems, 2022, 13:9, 768-700.e4
DOI: 10.1016/j.cels.2022.08.002

262

Early detection of cancer

D Crosby, S Bhatia, K M Brindle, L M Coussens, C Dive, M Emberton, S Esener, R C Fitzgerald, S S Gambhir, P Kuhn, T R Rebbeck and S Balasubramanian
Science, 2022, 375:6586
DOI: 10.1126/science.aay9040

261

G-quadruplex DNA structures in human stem cells and differentiation

K G Zyner, A Simeone, S M Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill and S Balasubramanian
Nature Communications, 2022, 13:142
DOI: 10.1038/s41467-021-27719-1

260

Single-cell mapping of DNA G-quadruplex structures in human cancer cells

W W I Hui, A Simeone, K Zyner, D Tannahill and S Balasubramanian
Scientific Reports, 2021, 11, 23641
DOI: 10.1038/s41598-021-02943-3

259

RNA G-quadruplex structures control ribosomal protein production

D Varshney, S Martínez Cuesta, B Herdy, U Abdullah, D Tannahill and S Balasubramanian
Scientific Reports, 2021, 11, 22735
DOI: 10.1038/s41598-021-01847-6

258

Chemical profiling of DNA G-quadruplex-interacting proteins in live cells

X Zhang, J Spiegel, S Martínez Cuesta, S Adhikari and S Balasubramanian
Nature Chemistry, 2021, 13, 626–633
DOI: 10.1038/s41557-021-00736-9

257

Promoter G-quadruplex folding precedes transcription and is controlled by chromatin

J Shen, D Varshney, A Simeone, X Zhang, S Adhikari, D Tannahill and S Balasubramanian
Genome Biology, 2021, 22, 143
DOI: 10.1186/s13059-021-02346-7

256

G-quadruplexes are transcription factor binding hubs in human chromatin

J Spiegel, S Martinez Cuesta, S Adhikari, R Hänsel-Hertsch, D Tannahill and S Balasubramanian
Genome Biology, 2021, 22, 117
DOI: 10.1186/s13059-021-02324-z

255

TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

R Broome, I Chernukhin, S Jamieson, K Kishore, E K Papachristou, S-Q Mao, C Gonzalez Tejedo, A Mahtey, V Theodorou, A J Groen, C D’Santos, S Balasubramanian, A Madalina Farcas, R Siersbæk, J S Carroll
Cell Reports, 2021, 34:8, 108776
DOI: 10.1016/j.celrep.2021.108776

254

Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis

M Nappi, A Hofer, S Balasubramanian and M Gaunt
J. Am. Chem. Soc., 2020, 21484-21492
DOI: 10.1021/jacs.0c10616

253

Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma

Y-Z Xu, P Jenjaroenpun, T Wongsurawat, S D Byrum, V Shponka, D Tannahill, E AnChavez, S S Hung, C Steidl, S Balasubramanian, L M Rimsza and S Kendrick
NAR Cancer, 2020, 2:4, zcaa029
DOI: 10.1093/narcan/zcaa029

252

Natural, modified DNA bases

M Bilyard, S Becker and S Balasubramanian
Currently. Op. in Chemistry. Bio., 2022, 57, 1-7
DOI: 10.1016/j.cbpa.2020.01.014

251

Landscape of G-quadruplex DNA structural regions in breast cancer

R Hänsel-Hertsch, A Simeone, A Shea, W Hui, K Zyner, G Marsico, O Rueda, A Bruna, A Martin, X Zhang, S Adhikari, D Tannahill, C Caldas and S Balasubramanian
Nature Genetics, 2020, 52, 878-883
DOI: 10.1038/s41588-020-0672-8

250

Single-molecule visualization of DNA G-quadruplex formation in live cells

M Di Antonio, A Ponjavic, A Radzevičius, R T Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, S F Lee, D Klenerman and S Balasubramanian
Nature Chemistry, 2020, 12, 832–837
DOI: 10.1038/s41557-020-0506-4

249

Genome-wide DNA Methylation Signatures Are Determined by DNMT3A/B Sequence Preferences

S-Q Mao, S Martinez Cuesta, D Tannahill and S Balasubramanian
Biochemistry, 2020, 59, 27, 2541–2550
DOI: 10.1021/acs.biochem.0c00339

248

The regulation and functions of DNA and RNA G-quadruplexes

D Varshney, J Spiegel, K Zyner, D Tannahill and S Balasubramanian
Nature Reviews Molecular Cell Biology, 2020, 21, 459–474
DOI: 10.1038/s41580-020-0236-x

247

Affinity-selected bicyclic peptide G-quadruplex ligands mimic a protein-like binding mechanism

K C Liu, K Röder, C Mayer, S Adhikari, D J Wales and S Balasubramanian
J. Am. Chem. Soc.2020, 142, 18, 8367-8373
DOI: 10.1021/jacs.0c01879

246

The structure and function of DNA G-Quadruplexes

J Spiegel, S Adhikari and S Balasubramanian
Trends in Chemistry, 2020, 2:2, 123-136
DOI: 10.1016/j.trechm.2019.07.002

245

A Spontaneous Ring‐Opening Reaction Leads to a Repair‐Resistant Thymine Oxidation Product in Genomic DNA

A Sahakyan, A Mahtey, F Kawasaki and S Balasubramanian
Chem. Bio. Chem., 2020, 21, 320-323
DOI: 10.1002/cbic.201900484

244

An Activatable Cancer-Targeted Hydrogen Peroxide Probe for Photoacoustic and Fluorescence Imaging

J Weber, L Bollepalli, A Belenguer, M Di Antonio, N De Mitri, J Joseph, S Balasubramanian, C Hunter and S Bohndiek
Cancer Res., 2019, 79, 5407
DOI: 10.1158/0008-5472.CAN-19-0691

243

Unusual Activity of a Chlamydomonas TET/JBP Family Enzyme

L Aravind, S Balasubramanian and A Rao
Biochemistry, 2019, 58, 3627-3629
DOI: 10.1021/acs.biochem.9b00609

242

Genetic interactions of G-quadruplexes in humans

K Zyner, D Mulhearn, S Adhikari, S Martínez Cuesta, M Di Antonio, N Erard, G Hannon, D Tannahill and S Balasubramanian
eLife, 2019, 8:e46793
DOI: 10.7554/eLife.46793

241

Sequencing abasic sites in DNA at single-nucleotide resolution

Z Liu, S Martínez Cuesta, P van Delft and S Balasubramanian
Nature Chemistry, 2019, 11, 629-637
DOI: 10.1038/s41557-019-0279-9

240

A Photo‐responsive Small‐Molecule Approach for the Opto‐epigenetic Modulation of DNA Methylation

H P Nguyen, S Stewart, M N Kukwikila, S F Jones, D Offenbartl-Stiegert, S Mao, S Balasubramanian, S Beck and S Howorka
Angew. Chem. Int. Ed., 2019, 58, 6620-6624
DOI: 10.1002/anie.201901139

239

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylations

L Pandolfini, I Barbieri, A Bannister, A Hendrick, B Andrews, N Webster, P Murat, P Mach, R Brandi, S Robson, V Migliori, A Alendar, M d’Onofrio, S Balasubramanian and T Kouzarides
Molecular Cell, 2019, 74, 1-13
DOI: 10.1016/j.molcel.2019.03.040

238

Detection, Structure and Function of Modified DNA Bases

A Hofer, Z Liu, S Balasubramanian
J. Am. Chem. Soc., 2019, 141, 16, 6420-6429
DOI: 10.1021/jacs.9b01915

237

Whole genome experimental maps of DNA G-quadruplexes in multiple species

G Marsico, V S Chambers, A B Sahakyan, P McCauley, J M Boutell, M Di Antonio, S Balasubramanian
Nucleic Acids Research, 2019, 47:8, 3862-3874
DOI: 10.1093/nar/gkz179

236

Structure of (3+1) hybrid G-quadruplex in the PARP1 promoter

A Sengar, J J Vandana, V S Chambers, M Di Antonio, F R Winnerdy, S Balasubramanian, A T Phan
Nucleic Acids Research, 2018, 47:3, 1564–1572
DOI: 10.1093/nar/gky1179

235

RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs

P Murat, G Marsico, B Herdy, A Ghanbarian, G Portella and S Balasubramanian
Genome Biology, 2018, 9:229
DOI: 10.1186/s13059-018-1602-2

234

5-Formylcytosine organises nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells

E-A Raiber, G Portella, S Martinez Cuesta, R Hardisty, P Murat, Z Li, M Iurlaro, W Dean, J Spindel, D Beraldi, Z Liu, M Dawson, W Reik and S Balasubramanian
Nature Chemistry, 2018, 10, 1258–1266
DOI: 10.1038/s41557-018-0149-x

233

DNA G-quadruplex structures mold the DNA methylome

S-Q Mao, A T Ghanbarian, J Spiegel, S Martinez Cuesta, D Beraldi, M Di Antonio, G Marsico, R Hansel-Hertsch, D Tannahill and S Balasubramanian
Nature Structural & Molecular Biology2018, 25, 951–957
DOI: 10.1038/s41594-018-0131-8

232

Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts

B Herdy, C Mayer, D Varshney, G Marsico, P Murat, C Taylor, C D’Santos, D Tannahill and S Balasubramanian
Nucleic Acids Research2018, 46:21, 11592–11604
DOI: 10.1093/nar/gky861

231

Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome

C K Kwok, G Marsico, S Balasubramanian
Cold Spring Harb. Prospect. Biol.2018, 10:a032284
DOI: 10.1101/cshperspect.a032284

230

Sequencing 5‐Hydroxymethyluracil at Single‐Base Resolution

F Kawasaki, S Martinez Cuesta, D Beraldi, A Mahtey, R Hardisty, M Carrington, S Balasubramanian
Angew. Chem. Int. Ed.2018, 57 (31), 9694-9696
DOI: 10.1002/anie.201804046

229

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

M C Chen, R Tippana, N A Demeshkina, P Murat, S Balasubramanian, S Myong and A R Ferré-D’Amaré
Nature2018, 558, 465–469
DOI: 10.1038/s41586-018-0209-9

228

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

A Parry, M Hoare, D Bihary, R Hansel-Hertsch, S Smith, K Tomimatsu, E Mannion, A Smith, P D’Santos, A Russell,  S Balasubramanian, H Kimura, S Samarajiwa and M Narita
Nature Communications2018, 9, 1840
DOI: 10.1038/s41467-018-04283-9

227

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing

R Hansel-Hertsch, J Spiegel, G Marsico, D Tannahill and S Balasubramanian
Nature Protocols2018, 13, 551-564
DOI: 10.1038/nprot.2017.150

226

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

C Marchetti, K G Zyner, S A Ohnmacht, M Robson, S M Haider, J P Morton, G Marsico, T Vo, S Laughlin-Toth, A A Ahmed, G Di Vita, I Pazitna, M Gunaratnam, R J Besser, A C G Andrade, S Diocou, J A Pike, D Tannahill, R B Pedley, T R J Evans, W D Wilson, S Balasubramanian and S Neidle
J. Med. Chem.2018, 61 (6), 2500–2517
DOI: 10.1021/acs.jmedchem.7b01781

225

Machine learning model for sequence-driven DNA G-quadruplex formation

A Sahakyan, V S Chambers, G Marsico, T Santner, M Di Antonio and S Balasubramanian
Scientific Reports2017, 7, 14535
DOI: 10.1038/s41598-017-14017-4

224

DNA sequencing at 40: past, present and future

J Shendure, S Balasubramanian, G M Church, W Gilbert, J Rogers, J A Schloss and R H Waterson
Nature2017, 550, 345-353
DOI: 10.1038/nature24286

223

Therapeutics: Click and discover

G Vassiliou and S Balasubramanian
Nature2017, 548, 162-164
DOI: 10.1038/548162a

222

Synthesis and multiple incorporations of 2′-O-methyl-5-hydroxymethyl-, 5-hydroxymethyl- and 5-formylcytidine monomers into RNA oligonucleotides

A Tanpure and S Balasubramanian
ChemBioChem2017, 18, 2236 –2241
DOI: 10.1002/cbic.201700492

221

Mapping and elucidating the function of modified bases in DNA

E-A Raiber, R Hardisty, P van Delft and S Balasubramanian
Nature Review Chemistry2017, 1, 0069
DOI: 10.1038/s41570-017-0069

220

Local epigenetic reprogramming induced by G-quadruplex ligands

G Guilbaud, P Murat, B Recolin, B Campbell, A Maiter, J E Sale and S Balasubramanian
Nature Chemistry2017, 9, 1110-1117
DOI: 10.1038/nchem.2828

219

The profile and dynamics of RNA modifications in animals

P Van Delft, A Akay, S M Huber, C Bueschl, K L M Rudolph, T Di Domenico, R Schuhmacher, E A Miska and S Balasubramanian
ChemBioChem2017, 18, 979-984
DOI: 10.1002/cbic.201700093

218

Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma

E-A Raiber, D Beraldi, S Martínez Cuesta, G R McInroy, Z Kingsbury, J Becq, T James, M Lopes, K Allinson, S Field, S Humphray, T Santarius, C Watts, D Bentley and S Balasubramanian
npj Genomic Medicine20172:6
DOI: 10.1038/s41525-017-0007-6

217

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

R Hänsel-Hertsch, M Di Antonio and S Balasubramanian
Nature Reviews Molecular Cell Biology2017, 18, 279–284
DOI: 10.1038/nrm.2017.3

216

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, N J O’Neil, N Dos Santos, J Silvester, V Wei, J Garcia, F Kabeer, D Lai, P Soriano, J Banáth, D S Chiu, D Yap, D D Le, F B Ye, A Zhang, K Thu, J Soong, S Lin, A Hsin Chin Tsai, T Osako, T Algara, D N Saunders, J Wong, J Xian, M B Bally, J D Brenton, G W Brown, S P Shah, D Cescon, T W Mak, C Caldas, P C Stirling, P Hieter, S Balasubramanian and S Aparicio
Nature Communications20178, 14432
DOI:10.1038/ncomms144328

215

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming

I Milagre, T M Stubbs, M R King, J Spindel, F Santos, F Krueger, M Bachman, A Segonds-Pichon, S Balasubramanian, S R Andrews, W Dean and W Reik
Cell Reports201718:5, 1079–1089
DOI: 10.1016/j.celrep.2017.01.008

214

Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania

F Kawasaki, D Beraldi, R E Hardisty, G R McInroy, P van Delft and S Balasubramanian
Genome Biology201718:23
DOI: 10.1186/s13059-017-1150-1

213

G-quadruplex structures within the 3’-UTR of LINE-1 elements stimulate retrotransposition

A B Sahakyan, P Murat, C Mayer and S Balasubramanian
Nature Str. Mol. Biol.201724, 243–247
DOI: 10.1038/nsmb.336

212

2′-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA

S M Huber, P van Delft, A Tanpure, E A Miska and S Balasubramanian
J. Am. Chem. Soc.2017139 (5), 1766–1769
DOI: 10.1021/jacs.6b12180

211

Single genome retrieval of context-dependent variability in mutation rates for human germline

A B Sahakyan and S Balasubramanian
BMC Genomics201718:81
DOI: 10.1186/s12864-016-3440-5

210

Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

F Kawasaki, P Murat, Z Li, T Santner and S Balasubramanian
Chem. Comm.2017, 53, 1389 – 1392
DOI: 10.1039/C6CC08670E

209

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

T A Horea, F von Meyenna, M Ravichandranc, M Bachman, G Ficz, D Oxley, F Santosa, S Balasubramanian, T P Jurkowskic, and W Reik
PNAS, 2016, 113:42, 12202-12207
DOI: 10.1073/pnas.1608679113

208

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing

H L Lightfoot, E A Miska and S Balasubramanian
Org. Biomol. Chem., 2016, 14, 10208-10216
DOI: 10.1039/c6ob01945e

207

G-quadruplex structures mark human regulatory chromatin

R Hänsel-Hertsch, D Beraldi, S V Lensing, G Marsico, K Zyner, A Parry, M Di Antonio, J Pike, H Kimura, M Narita, D Tannahill and S Balasubramanian
Nature Genetics, 2016, 48, 1267-1272
DOI: 10.1038/ng.3662

206

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome

C K Kwok, G Marsico, A B Sahakyan, V S Chambers and S Balasubramanian
Nature Methods, 2016, 13, 841-844
DOI: 10.1038/nmeth.3965

205

DSBCapture: in situ capture and sequencing of DNA breaks

S V Lensing, G Marsico, R Hänsel-Hertsch, E Y Lam, D Tannahill and S Balasubramanian
Nature Methods, 2016, 13, 855-857
DOI: 10.1038/nmeth.3960

204

An Epigenetics-Inspired DNA-Based Data Storage System

C Mayer, G R McInroy, P Murat, P van Delft and S Balasubramanian
Angew. Chem. Int. Ed., 2016, 55:37, 11144-11148
DOI: 10.1002/anie.201605531

203

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine

M Iurlaro, G R McInroy, H E Burgess, W Dean, E-A Raiber, M Bachman, D Beraldi, S Balasubramanian and W Reik
Genome Biology, 2016, 17:141
DOI: 10.1186/s13059-016-1001-5

202

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA

C K Kwok, A Sahakyan and S Balasubramanian
Angew. Chem. Int. Ed., 2016, 55, 8958-8961
DOI: 10.1002/anie.201603562

201

Enhanced Methylation Analysis by Recovery of Unsequenceable Fragments

G R McInroy, D Beraldi, E-A Raiber, K Modrzynska, P van Delft, O Billker and S Balasubramanian
PLoS ONE, 2016, 3: e)152322
DOI: 10.1371/journal.pone.0152322

200

Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases

A Sahakyan and S Balasubramanian
BMC Genomics, 2016, 17:225
DOI: 10.1186/s12864-016-2582-9

199

Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes

O S Walker, S J Elsas̈ser, M Mahesh, M Bachman, S Balasubramanian and J W Chin
J. Am. Chem. Soc., 2016, 138, 718 – 721
DOI: 10.1021/jacs.5b07627

198

Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies

S Patalano, A Vlasova, C Wyatt, P Ewels, F Camara, P G Ferreira, C L Asher, T P Jurkowski, A Segonds-Pichon, M Bachman, I González-Navarrete, A E Minoche, F Krueger, E Lowy, M Marcet-Houben, J L Rodriguez-Ales, F S Nascimento, S Balasubramanian, T Gabaldon, J E Tarver, S Andrews, H Himmelbauer, W O H Hughes, R Guigó, W Reik, and S Sumner
PNAS, 2016, 112, 13970 – 13975
DOI: 10.1073/pnas.1515937112

197

High-throughput sequencing of DNA G-quadruplex structures in the human genome

V S Chambers, G Marsico, J M Boutell, M Di Antonio, G P Smith and S Balasubramanian
Nature Biotechnology, 2015, 33, 877 – 881
DOI: 10.1038/nbt.3295

196

FOXM1 binds directly to non-consensus sequences in the human genome

D A Sanders, M V Gormally, G Marsico, D Beraldi, D Tannahill and S Balasubramanian
Genome Biology, 2015, 16:130
DOI: 10.1186/s13059-015-0696-z

195

5-Formylcytosine can be a stable DNA modification in mammals

M Bachman, S Uribe-Lewis, X Yang, H E Burgess, M Iurlaro, W Reik and S Balasubramanian
Nature Chemical Biology, 2015, 11, 555 – 557
DOI: 10.1038/nchembio.1848

194

Selective Chemical Labeling of Natural T Modifications in DNA

R E Hardisty, F Kawasaki, A B Sahakyan and S Balasubramanian
J. Am. Chem. Soc., 2015, 137, 9270 – 9272
DOI: 10.1021/jacs.5b03730

193

C K Kwok and S Balasubramanian
Angew. Chem. Int. Ed., 2015, 54, 6751 – 6754
DOI: 10.1002/anie.201500891

192

G-quadruplex ligands exhibit differential G-tetrad selectivity

D D Le, M Di Antonio, L K M Chan, and S Balasubramanian
Chem. Commun., 2015, 51, 8048 – 8050
DOI: 10.1039/C5CC02252E

191

Chemical Methods for Decoding Cytosine Modifications in DNA

M J Booth, E-A Raiber, and S Balasubramanian
Chem. Rev., 2015, 115, 2240 – 2254
DOI: 10.1021/cr5002904

190

Accurate Measurement of 5-Methylcytosine and 5-Hydroxymethylcytosine in Human Cerebellum DNA by Oxidative Bisulfite on an Array (OxBS-Array)

S F Field, D Beraldi, M Bachman, S K Stewart, S Beck, and S Balasubramanian
PloS ONE, 2015, 10:e0118202t
DOI: 10.1371/journal.pone.0118202

189

Formation and Abundance of 5-Hydroxymethylcytosine in RNA

S M Huber, P van Delft, L Mendil, M Bachman, K Smollett, F Werner, E A Miska and S Balasubramanian
ChemBioChem., 2015, 16, 752 – 755
DOI: 10.1002/cbic.201500013

188

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase

M C Chen, P Murat, K Abecassis, A R Ferre-D’Amare and S Balasubramanian
Nucleic Acids Res., 2015, 43, 2223 – 2231
DOI: 10.1093/nar/gkv051

187

Decoding Genomes

S Balasubramanian
Biochem. Soc. Trans., 2015, 43, 1 – 5
DOI: 10.1042/BST20140254

186

5-Formylcytosine alters the structure of the DNA double helix

E Raiber, P Murat, D Y Chirgadze, D Beraldi, B F Luisi and S Balasubramanian
Nature Structural & Molecular Biology, 2015, 22, 44 – 49
DOI: 10.1038/nsmb.2936

185

Dual binding of an antibody and a small molecule increases the stability of the TERRA G-quadruplex

P M Yangyuoru, M Di Antonio, C Ghimire, G Biffi, S Balasubramanian, and H Mao
Angew. Chem. Int. Ed., 2015, 54, 910 – 913
DOI: 10.1002/anie.201408113

184

oxBS-450K: A method for analysing hydroxymethylation using 450K BeadChips

S K Stewart, T J Morris, P Guilhamon, H Bulstrode, M Bachman, S Balasubramanian and S Beck
Methods, 2015, 72, 9 – 15
DOI: 10.1016/j.ymeth.2014.08.009

183

Solexa Sequencing: Decoding Genomes on a Population Scale

S Balasubramanian
Clin. Chem., 2015, 61, 21 – 24
DOI: 10.1373/clinchem.2014.221747

182

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition

M V Gormally, T S Dexheimer, G Marsico, D A Sanders, C Lowe, D Matak-Vinković, S Michael, A Jadhav, G Rai, D J Maloney, A Simeonov and S Balasubramanian
Nature Communications, 2014, 5:5165
DOI: 10.1038/ncomms6165

181

Targeting DNA G-Quadruplexes with Helical Small Molecules

S Müller, K Laxmi-Reddy, PV Jena, B Baptiste, Z Dong, F Godde, T Ha, R Rodriguez, S Balasubramanian and I Huc
Chembiochem., 2014, 15, 2563 – 2570
DOI: 10.1002/cbic.201402439

180

Nucleotide contributions to the structural integrity and DNA replication initiation activity of noncoding Y RNA

I Wang, M P Kowalski, A R Langley, R Rodriguez, S Balasubramanian, S T Hsu, and T Krude
Biochemistry, 2014, 53, 5848 – 5863
DOI: 10.1021/bi500470b

179

5-Hydroxymethylcytosine is a predominantly stable DNA modification

M Bachman, S Uribe-Lewis, X Yang, M Williams, A Murrell and S Balasubramanian
Nature Chemistry, 2014, 6, 1049 – 1055
DOI: 10.1038/nchem.2064

178

Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells

D Schiavone, G Guilbaud, P Murat, C Papadopoulou, P Sarkies, M Prioleau, S Balasubramanian and J E Sale
The EMBO Journal, 2014, 33, 2507 – 2520
DOI: 10.15252/embj.201488398

177

Chemical biology on genomic DNA: minimizing PCR bias

G McInroy, E Raiber, and S Balasubramanian
Chem. Commun., 2014, 50, 12047 – 12049
DOI: 10.1039/C4CC05107F

176

Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer

G Biffi, D Tannahill, J Miller, W J Howat and S Balasubramanian
PLoS ONE, 2014, 9, e102711
DOI: 10.1371/journal.pone.0102711

175

Chemical Biology on the Genome

S Balasubramanian
Bioorg. Med. Chem.,2014, 22, 4356 – 4370
DOI: 10.1016/j.bmc.2014.05.016

174

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

M Di Antonio, K I E McLuckie, and S Balasubramanian
J. Am. Chem. Soc., 2014, 136, 5860 – 5863
DOI: 10.1021/ja5014344

173

Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution

M J Booth, G Marsico, M Bachman, D Beraldi, and S Balasubramanian
Nature Chemistry, 2014, 6, 435 – 440
DOI: 10.1038/nchem.1893

172

G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation

P Murat, J Zhong, L Lekieffre, N P Cowieson, J L Clancy, T Preiss, S Balasubramanian, R Khanna and J Tellam
Nature Chemical Biology, 2014, 10, 358 – 364
DOI: 10.1038/nchembio.1479

171

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

G Biffi, M Di Antonio, D Tannahill and S Balasubramanian
Nature Chemistry, 2014, 6, 75 – 80
DOI: 10.1038/nchem.1805

170

Targeting a c-MYC G-quadruplex DNA with a fragment library

H R Nasiri, N Bell, K McLuckie, J Husby, C Abell, S Neidle and S Balasubramanian
Chem. Commun., 2014, 50, 1704 – 1707
DOI: 10.1039/C3CC48390H

169

Existence and consequences of G-quadruplex structures in DNA

P Murat and S Balasubramanian
Curr. Opin. Genet. Dev., 2014, 25, 22 – 29
DOI: 10.1016/j.gde.2013.10.012

168

The binding interaction between long non-coding RNA HOTAIR and PRC2 proteins

L Wu, P Murat, D Matak-Vinkovic, A Murrell and S Balasubramanian
Biochemistry, 2013, 52, 9519 – 9527
DOI: 10.1021/bi401085h

167

Targeting RNA-Protein Interactions within the Human Immunodeficiency Virus Type 1 Lifecycle

N Bell, A L’Hernault, P Murat, J E Richards, A M Lever, and S Balasubramanian
Biochemistry, 2013, 52, 9269 – 9274
DOI: 10.1021/bi401270d

166

Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes

P Yangyuoru, A Zhang, Z Shi, D Koirala, S Balasubramanian and H Mao
ChemBioChem., 2013, 14, 1931 – 1935.
DOI: 10.1002/cbic.201300350

165

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation

M Iurlaro, G Ficz, D Oxley, E Raiber, M Bachman, M J Booth, S Andrews, S Balasubramanian and W Reik
Genome Biology, 2013, 14:R119
DOI: 10.1186/gb-2013-14-10-r119

164

Oxidative Bisulfite sequencing of 5-methylcytosine and 5-hydroxymethlcytosine

M J Booth, T W B Ost, D Beraldi, N Bell, M Branco, W Reik and S Balasubramanian
Nature Protocols, 2013, 8, 1841 – 1851
DOI: 10.1038/nprot.2013.115

163

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

P Murat, M V Gormally, D Sanders, M Di Antonio and S Balasubramanian
Chem. Commun., 2013, 49, 8453 – 8455
DOI: 10.1039/C3CC44737E

162

G-quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells

K I E McLuckie, M Di Antonio, H Zecchini, J Xian, C Caldas, B F Krippendorff, D Tannahill, C Lowe and S Balasubramanian
J. Am. Chem. Soc., 2013, 135, 9640 – 9643
DOI: 10.1021/ja404868t

161

G-quadruplex structures are stable and detectable in human genomic DNA

E Yi Ni Lam, D Beraldi, D Tannahill and S Balasubramanian
Nature Communications, 2013, 4, 1796
DOI: 10.1038/ncomms2792

160

Down-regulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer

T Mitchell, A Ramos-Montoya, M Di Antonio, P Murat, S Ohnmacht, M Micco, S Jurmeister, L Fryer, S Balasubramanian, S Neidle and D E Neal
Biochemistry, 2013, 52, 1429 – 1436
DOI: 10.1021/bi301349c

159

Genome-wide mapping of FOXM1 binding reveals co binding with estrogen receptor alpha in breast cancer cells

D A Sanders, C S Ross-Innes, D Beraldi, J S Carroll and S Balasubramanian
Genome Biology, 2013, 14:R6
DOI: 10.1186/gb-2013-14-1-r6

158

Quantitative visualization of DNA G-quadruplex structures in human cells

G Biffi, D Tannahill, J McCafferty and S Balasubramanian
Nature Chemistry, 2013, 5, 182 – 186
DOI: 10.1038/nchem.1548

157

An Acetylene-Bridged 6,8-Purine Dimer as a Fluorescent Switch-On Probe for Parallel G-Quadruplexes

M Nikan, M Di Antonio, K Abecassis, K McLuckie and S Balasubramanian
Angew. Chem. Int. Ed. , 2013, 52, 1428 – 1431
DOI: 10.1002/anie.201207075

156

An RNA Hairpin to G-Quadruplex Conformational Transition

A Bugaut, P Murat and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 19953 – 19956
DOI: 10.1021/ja308665g

155

The Kinetics and Folding Pathways of Intramolecular G-Quadruplex Nucleic Acids

A Zhang and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 19297 – 19308
DOI: 10.1021/ja309851t

154

Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

M Di Antonio, G Biffi, A Mariani, E-A Raiber, R Rodriguez and S Balasubramanian
Angew. Chem. Int. Ed, 2012, 51, 11073 – 11078
DOI: 10.1002/anie.201206281

153

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

S Müller, D A Sanders, M Di Antonio, S Matsis, J F Riou, R Rodriguez and S Balasubramanian
Org. Biomol. Chem., 2012, 10, 6537 – 6546
DOI: 10.1039/C2OB25830G

152

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase

E-A Raiber, D Beraldi, G Ficz, H Burgess, M R Branco, P Murat, D Oxley, M J Booth, W Reik and S Balasubramanian
Genome Biology, 2012, 13:R69
DOI: 10.1186/gb-2012-13-8-r69

151

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2

G Biffi, D Tannahill and S Balasubramanian
J. Am. Chem. Soc., 2012, 134, 11974 – 11976
DOI: 10.1021/ja305734x

150

50-UTR RNA G-quadruplexes: translation regulation and targeting

A Bugaut and S Balasubramanian
Nucleic Acids Res., 2012, 40, 4727 – 4741
DOI: 10.1093/nar/gks068

149

Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution

M J Booth, M R Branco, G Ficz, D Oxley, F Krueger, W Reik and S Balasubramanian
Science, 2012, 336, 934 – 937
DOI: 10.1126/science.1220671

148

Experimental Approaches to Identify Cellular G-quadruplex Structures and Functions

M Di Antonio, R Rodriguez and S Balasubramanian
Methods, 2012, 57, 84 – 92
DOI: 10.1016/j.ymeth.2012.01.008

147

Comparative Structural Effects of HIV-1 Gag and Nucleocapsid Proteins in Binding to and Unwinding of the Viral RNA Packaging Signal

N M Bell, J C Kenyon, S Balasubramanian and A M L Lever
Biochemistry, 2012, 51, 3162 – 3169
DOI: 10.1093/nar/gks068

146

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

R Rodriguez, K M Miller, J V Forment, C R Bradshaw, M Nikan, S Britton, T Oelschlaegel, B Xhemalce, S Balasubramanian and S P Jackson
Nature Chemical Biology, 2012, 8, 301 – 310
DOI: 10.1038/nchembio.780

145

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

P Sarkies, P Murat, L G Phillips, K J Patel, S Balasubramanian and J E Sale
Nucleic Acids Res., 2012, 40, 1485 – 1498
DOI: 10.1093/nar/gkr868

144

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

E-A Raiber, R Kranaster, E Lam, M Nikan and S Balasubramanian
Nucleic Acids Res., 2012, 40, 1499 – 1508
DOI: 10.1093/nar/gkr882

143

Demonstration of Ligand Decoration, and Ligand-Induced Perturbation, of G-Quadruplexes in a Plasmid Using Atomic Force Microscopy

I Mela, R Kranaster, R M Henderso, S Balasubramanian and J M Edwardson
Biochemistry, 2012, 51, 578 – 585
DOI: 10.1021/bi201600g

142

Synthesis of Bis-indole Carboxamides as G-Quadruplex Stabilizing and Inducing Ligands

J Dash, R N Das, N Hegde, G D Pantoş, P Shirude and S Balasubramanian
Chem. Eur. J., 2012, 18, 554 – 64
DOI: 10.1002/chem.201102556

141

Decoding genomes at high speed: implications for science and medicine

S Balasubramanian
Angew. Chem. Int. Ed., 2011, 50, 12406 – 12410
DOI: 10.1002/anie.201106707

140

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

D Koirala, S Dhakal, B Ashbridge, Y Sannohe, R Rodriguez, H Sugiyama, S Balasubramanian and H Mao
Nature Chemistry, 2011, 3, 782 – 787
DOI: 10.1038/nchem.1126

139

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton

N S Hegde, D A Sanders, R Rodriguez and S Balasubramanian
Nature Chemistry, 2011, 3, 725 – 731
DOI: 10.1038/nchem.1114

138

A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing

H L Lightfoot, A Bugaut, J Armisen, N J Lehrbach, E A Miska and S Balasubramanian
Biochemistry, 2011, 50, 7514 – 7521
DOI: 10.1021/bi200851d

137

A Sequence-Independent Analysis of the Loop Length Dependence of Intramolecular RNA G-Quadruplex Stability and Topology

A Zhang, A Bugaut and S Balasubramanian
Biochemistry, 2011, 50, 7251 – 7258
DOI: 10.1021/bi200805j

136

Sequencing nucleic acids: from chemistry to medicine

S Balasubramanian
Chem. Commun., 2011, 47, 7281 – 7286
DOI: 10.1039/c1cc11078k Highlight

135

Targeting G‐quadruplexes in gene promoters: a novel anticancer strategy?

S Balasubramanian, L H Hurley and S Neidle
Nature Reviews Drug Discovery, 2011, 10, 261 – 275
DOI: 10.1038/nrd3428

134

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae

J S Smith, Q Chen, L A Yatsunyk, J M Nicoludis, M S Garcia, R Kranaster, S Balasubramanian, D Monchaud, M Teulade-Fichou, L Abramowitz, D C Schultz and F B Johnson
Nature Structural & Molecular Biology, 2011, 18, 478 – 485
DOI: 10.1038/nsmb.2033

133

Synthesis and Binding Studies of Novel Diethynyl-pyridine Amides with Genomic Promoter DNA G-quadruplexes

J Dash, Z A E Waller, G D Pantos and S Balasubramanian
Chem. Eur. J., 2011, 17, 4571 – 4581
DOI: 10.1002/chem.201003157

132

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells

K I E McLuckie, Z A E Waller, D A Sanders, D Alves, R Rodriguez, J Dash, G J McKenzie, A R Venkitaraman and S Balasubramanian
J. Am. Chem. Soc., 2011, 133, 2658 – 2663
DOI: 10.1021/ja109474c

131

Small-molecule-mediated G-quadruplex isolation from human cells

S Müller, S Kumari, R Rodriguez and S Balasubramanian
Nature Chemistry, 2010, 2, 1095 – 1098
DOI: 10.1038/NCHEM.842

130

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines

M Bejugam, M Gunaratnam, S Müller, D A Sanders, S Sewitz, J A Fletcher, S Neidle and S Balasubramanian
ACS Med. Chem. Lett., 2010, 1, 306 – 310
DOI: 10.1021/ml100062z

129

Distinct functions of maternal and somatic Pat1 protein paralogs

A Marnef, M Maldonado, A Bugaut, S Balasubramanian, M Kress, D Weil and N Standart
RNA, 2010, 16, 2094 – 2107
DOI: 10.1261/rna.2295410

128

The BCL-2 5′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif that Modulates Protein Expression

R Shahid, A Bugaut and S Balasubramanian
Biochemistry, 2010, 49, 8300 – 8306
DOI: 10.1021/bi100957h

127

Small Molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

A Bugaut, R Rodriguez, S-T D Hsu and S Balasubramanian
Org. Biomol. Chem., 2010, 8, 2771 – 2776
DOI: 10.1039/c002418j

126

RNA Conformation in Catalytically Active Human Telomerase

J A Yeoman, A Orte, B Ashbridge, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2010, 132, 2852 – 2853
DOI: 10.1021/ja909383n

124

Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes

A Fegan, P S Shirude, L Ying and S Balasubramanian
Chem. Commun., 2010, 46, 946 – 948
DOI: 10.1039/b920680a

124

Single-Molecule Analysis of the Human Telomerase RNA·Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations

B Ashbridge, A Orte, J A Yeoman, M Kirwan, T Vulliamy, I Dokal, D Klenerman and S Balasubramanian
Biochemistry, 2009, 48, 10858 – 10865
DOI: 10.1021/bi901373e

123

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression

H Fernando, S Sewitz, J Darot, S Tavaré, J L Huppert and S Balasubramanian
Nucleic Acids Research, 2009, 37, 6716 – 6722
DOI: 10.1093/nar/gkp740

122

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

N J Lehrbach, J Armisen, H L Lightfoot, K J Murfitt, A Bugaut, S Balasubramanian and E A Miska
Nature Structural & Molecular Biology, 2009, 16, 1016 – 1020
DOI:10.1038/nsmb.1675

121

A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

S-T Hsu, P Varnai, A Bugaut, A P Reszka, S Neidle and S Balasubramanian
J. Am. Chem. Soc., 2009, 131, 13399 – 13409
DOI: 10.1021/ja904007p

120

G-quadruplex DNA bound by a synthetic ligand is highly dynamic

P V Jena, P S Shirude, B Okumus, K Laxmi-Reddy, F Godde, I Huc, S Balasubramanian and T Ha
J. Am. Chem. Soc., 2009, 131, 12522 – 12523
DOI: 10.1021/ja903408r

119

A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression

Z A E Waller, S A Sewitz, S-T Hsu and S Balasubramanian
J. Am. Chem. Soc., 2009, 131, 12628 – 12633
DOI: 10.1021/ja901892u

118

G-quadruplex nucleic acids as therapeutic targets

S Balasubramanian and S Neidle
Curr. Opin. Chem. Bio., 2009, 13, 345 – 353
DOI: 10.1016/j.cbpa.2009.04.637

117

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

S Müller, G Dan Pantos, R Rodriguez and S Balasubramanian
Chem. Commun., 2009, 80 – 82
DOI: 10.1039/B816861J

116

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates

J E Redman, J M Granadino-Roldán, J A Schouten, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2009, 7, 76 – 84
DOI: 10.1039/b814682a

115

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

T B C London, L J Barber, G Mosedale, G P Kelly, S Balasubramanian, I D Hickson, S J Boulton and K Hiom
J. Biol. Chem., 2008, 283, 36132 – 36139
DOI: 10.1074/jbc.M808152200

114

Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of the NRAS Proto-oncogene

S Kumari, A Bugaut and S Balasubramanian
Biochemistry, 2008, 47, 12664 – 12669
DOI: 10.1021/bi8010797

113

Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes

J Dash, P S Shirude, S-T D Hsu and S Balasubramanian
J. Am. Chem. Soc., 2008, 130, 15950 – 15956
DOI: 10.1021/ja8046552

112

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

R Rodriguez, S Müller, J A Yeoman, C Trentesaux, J-F Riou and S Balasubramanian
J. Am. Chem. Soc., 2008, 130, 15758 – 15759
DOI: 10.1021/ja805615w

111

Accurate whole human genome sequencing using reversible terminator chemistry

D R Bentley, S Balasubramanian, H P Swerdlow et al.
Nature, 2008, 456, 53 – 59
DOI: 10.1038/nature07517

110

G-quadruplexes: the beginning and end of UTRs

J L Huppert, A Bugaut, S Kumari and S Balasubramanian
Nucleic Acids Res., 2008, 36, 6260 – 6268
DOI: 10.1093/nar/gkn511

109

Selective Recognition of a DNA G-Quadruplex by an Engineered Antibody

H Fernando, R Rodriguez and S Balasubramanian
Biochemistry, 2008, 47, 9365 – 9371
DOI: 10.1021/bi800983u

108

Single molecule conformational analysis of DNA G-quadruplexes

P S Shirude and S Balasubramanian
Biochimie, 2008, 90, 1197 – 1206
DOI: 10.1039/b801465e

107

G-quadruplex recognition by bis-indole carboxamides

J Dash, P S Shirude and S Balasubramanian
Chem. Commun., 2008, 3055 – 3057
DOI: 10.1039/b806042h

106

Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC

P S Shirude, L Ying and S Balasubramanian
Chem. Commun., 2008, 2007 – 2009
DOI: 10.1039/b801465e

105

Rigid cyanine dye nucleic acid labels

A Fegan, P S Shirude and S Balasubramanian
Chem. Commun., 2008, 2004 – 2006
DOI: 10.1039/b801629a

104

Single-molecule analysis of human telomerase monomer

D Alves, H Li, R Codrington, A Orte, X Ren, D Klenerman and S Balasubramanian
Nature Chemical Biology, 2008, 4, 287 – 289
DOI: 10.1038/nchembio.82

103

Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry

A Bugaut, K Jantos, J-L Wietor, R Rodriguez, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 2008, 47, 2677 – 2680
DOI: 10.1002/anie.200705589

102

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition

Z A E Waller, P Shirude, R Rodriguez and S Balasubramanian
Chem. Commun., 2008, 1467 – 1469
DOI: 10.1039/b718854d

101

A Sequence-Independent Study of the Influence of Short Loop Lengths on the Stability and Topology of Intramolecular DNA G-Quadruplexes

A Bugaut and S Balasubramanian
Biochemistry, 2008, 47, 689 – 697
DOI: 10.1021/bi701873c1

100

Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression

M Bejugam, S Sewitz, S P Shirude, R Rodriquez, R Shahid and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 12926 – 12927
DOI: 10.1021/ja075881p

99

Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands

P S Shirude, E R Gillies, S Ladame, F Godde, K Shin-ya, I Huc and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 11890 – 11891
DOI: 10.1021/ja073775h

98

Ligand-Driven G-Quadruplex Conformational Switching By Using an Unusual Mode of Interaction

R Rodriguez, G Dan Pantos, D P N Goncalves, J K M Sanders and S Balasubramanian
Angew. Chem. Int. Ed., 2007, 46, 5404 – 5407
DOI: 10.1002/anie.200605075

97

Single-Molecule Conformational Analysis of G-Quadruplex Formation in the Promoter DNA Duplex of the Proto-Oncogene C-Kit

P S Shirude, B Okumus, L Ying, T Ha and S Balasubramanian
J. Am. Chem. Soc., 2007, 129, 7484 – 7485
DOI: 10.1021/ja070497d

96

An RNA G-quadruplex in the 5‘ UTR of the NRAS proto-oncogene modulates translation

S Kumari, A Bugaut, J L Huppert and S Balasubramanian
Nature Chemical Biology, 2007, 3, 218 – 221
DOI: 10.1038/nchembio864

95

G-quadruplexes in promoters throughout the human genome

J L Huppert and S Balasubramanian
Nucleic Acids Res., 2007, 35, 2, 406 – 413
DOI: 10.1093/nar/gkm109

94

Tetramethylpryidiniumporphyrazines – a new class of G-quadruplex inducing and stabilising ligands

D P Goncalves, R Rodriguez, S Balasubramanian and J K M Sanders
Chem. Commun., 2006, 4685 – 4687
DOI: 10.1039/b611731g

93

Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library

J E Redman, S Ladame, A P Reszka, S Neidle and S Balasubramanian
Org. Biomol. Chem., 2006, 4, 4364 – 4369
DOI: 10.1039/B611716C

92

A Simple Nanomixer for Single-Molecule Kinetics Measurements

S S White, S Balasubramanian, D Klenerman and L Ying
Angew. Chem. Int. Ed., 2006, 45, 7540 – 7543
DOI: 10.1002/anie.200602289

91

Determination of the Fraction and Stoichiometry of Femtomolar Levels of Biomolecular Complexes in an Excess of Monomer Using Single-Molecule, Two-Color Coincidence Detection

A Orte, R Clarke, S Balasubramanian and D Klenerman
Anal. Chem., 2006 78, 7707 – 7715
DOI: 10.1021/ac061122y

90

Structural Analysis of the Catalytic Core of Human Telomerase RNA by FRET and Molecular Modeling

G Gavory, M F Symmons, Y Krishnan Ghosh, D Klenerman and S Balasubramanian
Biochemistry, 2006, 45, 13304 – 13311
DOI: 10.1021/bi061150a

89

Oxazole-Based Peptide Macrocycles: A New Class of G-Quadruplex Binding Ligands

K Jantos, R Rodriguez, S Ladame, P S Shirude and S Balasubramanian
J. Am. Chem. Soc., 2006, 128, 13662 – 13663
DOI: 10.1021/ja064713e

88

Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins

D P N Goncalves, S Ladame, S Balasubramanian and J K M Sanders
Org. Biomol. Chem., 2006, 4, 3337 – 3342
DOI: 10.1039/b608494j

87

Investigating a quadruplex-ligand interaction by unfolding kinetics

J J Green, S Ladame, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2006, 126, 9809 – 9812
DOI: 10.1021/ja0615425

86

A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene

H Fernando, A P Reszka, J Huppert, S Ladame, S Rankin, A R Venkitaraman, S Neidle and S Balasubramanian
Biochemistry, 2006, 45, 7854 – 7860
DOI: 10.1021/bi0601510

85

Analysis of Human Telomerase Activity and Function by Two Color Single Molecule Coincidence Fluorescence Spectroscopy

X Ren, H Li, R W Clarke, D A Alves, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2006, 128, 4992 – 5000
DOI: 10.1021/ja056613z

84

A Reversible pH-Driven DNA Nanoswitch Array

D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman and D Zhou
J. Am. Chem. Soc., 2006, 128, 2067 – 2071
DOI: 10.1021/ja0568300

83

Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein

S Ladame, J A Schouten, J Roldan, J E Redman, S Neidle and S Balasubramanian
Biochemistry, 2006, 45, 1393 – 1399
DOI: 10.1021/bi050229x

82

DNA molecular motor driven micromechanical cantilever arrays

W Shu, D Liu, M Watari, C K Riener, T Strunz, M E Welland, S Balasubramanian and R McKendry
J. Am. Chem. Soc., 2005, 127, 17054 – 17060
DOI: 10.1021/ja0554514

81

PNA forms an i-motif

Y Krishnan-Ghosh, E Stephens and S Balasubramanian
Chem. Commun., 2005, 5278 – 5280
DOI: 10.1039/B510405J

80

Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach

S Ladame, A Whitney and S Balasubramanian
Angew. Chem. Int. Ed., 2005, 44, 5736 – 5739
DOI: 10.1002/anie.200501450

79

Putative DNA quadruplex formation within the human c-kit oncogene

S Rankin, A P Reszka, J Huppert, M Zloh, G N Parkinson, A K Todd, S Ladame, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 2005, 127, 10584 – 10589
DOI: 10.1021/ja050823u

78

Dynamic covalent chemistry on self-templating PNA oligomers: formation of a bimolecular PNA quadruplex

Y Krishnan-Ghosh and S Balasubramanian
Chem. Commun., 2005, 3068 – 3070
DOI: 10.1039/B503578C

77

Prevalence of quadruplexes in the human genome

J L Huppert and S Balasubramanian
Nucleic Acids Res., 2005, 33, 2908 – 2916
DOI: 10.1093/nar/gki609

76

Solid-phase methods for the synthesis of cyanine dyes

S Mason, J Hake, J Nairne, E J Cummins and S Balasubramanian
J. Org. Chem., 2005, 70, 2939 – 2949
DOI: 10.1021/jo0479415

75

Loop-length dependent folding of G-quadruplexes

P Hazel, J Huppert, S Balasubramanian and S Neidle
J. Am. Chem. Soc., 2004, 126, 16405 – 16415
DOI: 10.1021/ja045154j

74

Individual molecules of dye-labeled DNA act as a reversible two-colour switch upon application of an electric field

S S White, L Ying, S Balasubramanian and D Klenerman
Angew. Chem. Int. Ed., 2004, 43, 5926 – 5930
DOI: 10.1021/jp036715g

73

Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes

S D Patel, M Isalan, G Gavory, S Ladame, Y Choo and S Balasubramanian
Biochemistry, 2004, 43, 13452 – 13458
DOI: 10.1021/bi048892t

72

Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform

S Ladame, J A Schouten, J Stuart, J Roldan, S Neidle and S Balasubramanian
Org. Biomol. Chem., 20042, 2925 – 2931
DOI: 10.1039/B409698C

71

Measuring Single Molecule Nucleic Acid Dynamics in Solution by Two-Color Filtered Ratiometric Fluorescence Correlation Spectroscopy

H Li, X Ren, S Balasubramanian and D Klenerman
PNAS, 2004, 101, 14425 – 14430
DOI: 10.1073/pnas.0404295101

70

Formation of an Interlocked Quadruplex Dimer by d(GGGT)

Y Krishnan-Ghosh, D Liu and S Balasubramanian
J. Am. Chem. Soc. , 2004, 125, 11009 – 11016
DOI: 10.1021/ja049259y

69

Studies on the chemical stability and synthetic utility of an oxazolidine linker for solid-phase chemistry

A J Wills, M Cano and S Balasubramanian
J. Org. Chem., 2004, 69, 5439 – 47
DOI: 10.1021/jo049569z

69

Studies on the chemical stability and synthetic utility of an oxazolidine linker for solid-phase chemistry

A J Wills, M Cano and S Balasubramanian
J. Org. Chem., 2004, 69, 5439 – 47
DOI: 10.1021/jo049569z

68

Molecule by molecule direct and quantitative counting of antibody complexes in solution

H Li, L Ying, S Balasubramanian and D Klenerman
Anal. Chem., 2004, 76, 4446 – 51
DOI: 10.1021/ac049512c

67

A PNA4 Quadruplex

Y Krishnan-Ghosh, E Stephens and S Balasubramanian
J. Am. Chem. Soc., 2004, 126, 5944 – 5945
DOI: 10.1021/ja031508f

66

Targeting the Single-Stranded Overhang of Telomeres with PNA Inhibits Cell Growth and Induces Apoptosis of Human Immortal Cells

M A Shammas, X Liu, G Gavory, K D Raney, S Balasubramanian and R J Shmookler Reis
Experimental Cell Research, 2004, 295, 204 – 214
DOI: 10.1016/j.yexcr.2004.01.003

65

Templated Ligand Assembly using G-quadruplex DNA and Dynamic Covalent Chemistry

A Whitney, S Ladame and S Balasubramanian
Angew. Chem. Int. Ed., 2004, 43, 1143 – 1146
DOI: 10.1002/anie.200353069

64

Studies on the Structure and Dynamics of the Human Telomeric Quadruplex by Single Molecule Fluorescence Resonance Energy Transfer

L Ying, J J Green, H Li, D Klenerman and S Balasubramanian
PNAS, 2003, 100, 14629 – 14634
DOI: 10.1073/pnas.2433350100

63

A proton fuelled DNA nanomachine

D Liu and S Balasubramanian
Angew. Chem. Int. Ed., 2003, 42, 5734 – 5736
DOI: 10.1002/anie.200352402

62

Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenital point mutation

X Ren, G Gavory, H Li, L Ying, D Klenerman and S Balasubramanian
Nucleic Acids Res., 2003, 31, 6509 – 6515
DOI: 10.1093/nar/gkg871

61

From the combinatorial chemistry boom to polymer-supported parallel chemistry: established technologies for drug discovery

M Cano and S Balasubramanian
Drugs of the Future, 2003, 28, 659 – 678
DOI: 10.1002/chin.200446268

60

Recent Developments in Linker Design and Application

A J Wills and S Balasubramanian
Curr. Op. Chem. Biol., 2003, 7, 346 – 352
DOI: 10.1016/S1367-5931(03)00035-8

59

Dynamic Covalent Chemistry on Self-Templating Peptides: Formation of a Disulfide-linked β-Hairpin Mimic

Y Krishnan-Ghosh and S Balasubramanian
Angew. Chem. Int. Ed., 2003, 42, 2171 – 2173
DOI: 10.1002/anie.200250551

58

G-Quadruplex-Specific Peptide-Hemicyanine Ligands by Partial Combinatorial Selection

J A Schouten, S Ladame, S J Mason, M A Cooper and S Balasubramanian
J. Am. Chem. Soc., 2003, 125, 5594 – 5595
DOI: 10.1021/ja029356w

57

Kinetics of Unfolding the Human Telomeric DNA Quadruplex using a PNA Trap

J Green, L Ying, D Klenerman and S Balasubramanian
J. Am. Chem. Soc., 2003, 125, 3763 – 3767
DOI: 10.1021/ja029149w

56

Ultrasensitive coincidence fluorescence detection of single DNA molecules

H Li, L Ying, J J Green, S Balasubramanian and D Klenerman
Anal. Chem., 2003, 75, 1664 – 1670
DOI: 10.1021/ac026367z

55

Site-Specific Cleavage of Human Telomerase RNA using PNA-Neocuproine.Zn(II) derivatives

A Whitney, G Gavory and S Balasubramanian
Chem. Commun., 2003, 36 – 37
DOI: 10.1039/B210135A

54

PNA and oligonucleoide inhibitors of human telomerase

G Gavory and S Balasubramanian
Telomerases, Telomeres and Cancer Eds., G Krupp and R Parwaresch 67-80, Landes Bioscience: Austin, 2003

53

Solid phase catch-activate and release synthesis of cyanine dyes

S J Mason and S Balasubramanian
Org. Lett., 2002, 4, 4261 – 62
DOI: 10.1021/ol026836j

52

Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro

G Gavory, M Farrow and S Balasubramanian
Nucleic Acids Res., 2002, 30, 4470 – 4480

51

Synthesis of a polymer supported oxazolidine aldehyde for asymmetric chemistry

A J Wills, Y Krishnan-Ghosh and S Balasubramanian
J. Org. Chem., 2002, 67, 6646 – 6652
DOI: 10.1021/jo0203239

50

Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation

I Horsey, Y Krishnan-Ghosh and S Balasubramanian
Chem. Commun., 2002, 14, 1950 – 51
DOI: 10.1039/B206054J

49

Solid phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates

S Ladame, R J Harrison, S Neidle and S Balasubramanian
Org. Lett., 2002, 4, 2509 – 2512
DOI: 10.1021/ol026130p

48

Synthesis of diastereomerically pure 1,4,5-substituted-2-oxopiperazines on solid-phase

N M Khan, M Cano and S Balasubramanian
Tetrahedron Lett., 2002, 43, 2439 – 2443
DOI: 10.1016/S0040-4039(02)00268-X

47

Practical synthesis of a dithiane protected 3′,5′-dialkyoxybenzoin photolabile safety-catch linker (BPSC) for solid phase organic synthesis

M Cano, M Ladlow and S Balasubramanian
J. Org. Chem., 2002, 67, 129 – 135
DOI: 10.1021/jo010703e

46

Studies on the chemical stability and functional group compatibility of the Benzoin Photolabile Safety-catch (BPSC) linker using an analytical construct

M Cano, M Ladlow and S Balasubramanian
J. Comb. Chem., 2002, 4, 44 – 48
DOI: 10.1021/cc010040e

45

Solid Phase Chemical Technologies for Combinatorial Chemistry

S Balasubramanian
J. Cell. Biochem. Suppl., 2001, 37, 28 – 33

44

Non-Arrhenius kinetics of a DNA Hairpin-Loop

L Ying, M I Wallace, S Balasubramanian and D Klenerman
PNAS, 2001, 98, 5584 – 5589
DOI: 10.1073/pnas.10152349844

43

Probing DNA surface attachment and local environment using single molecule spectroscopy

M A Osborne, C L Barnes, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2001, 105, 3120 – 3126
DOI: 10.1021/jp0038660

42

Selection of Zinc Fingers that Bind Single-Stranded Telomeric DNA in the G-Quadruplex Conformation

M Isalan, S D Patel, S Balasubramanian and Y Choo
Biochemistry, 2001, 40, 830 – 836
DOI: 10.1021/bi001728v

41

Exploring a Benzyloxyaniline Linker Utilizing Ceric Ammonium Nitrate (CAN) as a Cleavage Reagent: Solid-Phase Synthesis of N-Unsubstituted Beta-Lactams and Secondary Amides

K Gordon and S Balasubramanian
Org. Lett., 2001, 3, 53 – 56
DOI: 10.1021/ol006766l

40

The science of chemical discovery: probing the unknown with new technologies

S Balasubramanian
Drug Discovery Today, 2000, 5, 533-534
DOI: 10.1016/S1359-6446(00)01582-8

39

FRET Fluctuation Spectroscopy: Exploring the Conformational Dynamics of a DNA Hairpin Loop

M I Wallace, L Ying, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2000, 104, 11551 – 11555
DOI: 10.1021/jp001560n

38

A stereoselective synthesis of 1,3,4-substituted -lactams from polymer-supported chiral oxazolidine aldehyde

K Gordon, M Bolger, N Khan and S Balasubramanian
Tetrahedron Lett., 2000, 41, 8621 – 8625
DOI: 10.1021/ol2020048

37

Strategies for the synthesis of fluorescently labelled PNA

X Liu and S Balasubramanian
Tetrahedron Lett., 2000, 41, 6153 – 6156
DOI: 10.1016/S0040-4039(00)00996-5

35

Single Molecule Analysis of DNA Immobilised on Microspheres

M A Osborne, W S Furey, D Klenerman and S Balasubramanian
Anal. Chem., 2000, 72, 3678 – 3681
DOI: 10.1021/ac000129r

35

Ratiometric analysis of single-molecule fluorescence resonance energy transfer using logical combinations of threshold criteria: A study of 12-mer DNA

L Ying, M I Wallace, S Balasubramanian and D Klenerman
J. Phys. Chem. B., 2000, 104, 5171 – 5178
DOI: 10.1021/jp993914k

34

Recent Developments in the Encoding and Deconvolution of Combinatorial Libraries

C L Barnes and S Balasubramanian
Curr. Opin. Chem. Bio., 2000, 4, 346 – 350
DOI: 10.1016/S1367-5931(00)00098-3

33

Double Fluorescence Resonance Energy Transfer to Explore Multicomponent Binding Interactions: A Case Study of DNA Mismatches

I Horsey, W S Furey, J G Harrison, M A Osborne and S Balasubramanian
Chem. Commun., 2000, 12, 1043 – 1044
DOI: 10.1039/B002540M

32

Solid-Phase Synthesis of N-Alkyl-N-(β-keto)amides and 1,2,4,5-Tetrasubstituted Imidazoles Using a Traceless Cleavage Strategy

H B Lee and S Balasubramanian
Org. Lett., 2000, 2, 323 – 326
DOI: 10.1021/ol991271l
Read Article

267

A Photoredox Reaction for the Selective Modification of 5-Carboxycytosine in DNA

B J Mortishire-Smith, S M Becker, A Simeone, L Melidis and S Balasubramanian
J. Am. Chem. Soc., 2023, early online article
DOI: 10.1021/jacs.2c12558

31

Screening for Oligonucleotide Binding Affinity by a Convenient Fluorescence Competition Assay

J G Harrison, X Liu and S Balasubramanian
Nucleic Acids Research, 1999, 27, e14
DOI: 10.1093/nar/27.17.e14

30

Thermodynamic Melting Studies on Oligonucleotide-Peptide Conjugates

C Frier, J G Harrison and S Balasubramanian
Nucleosides and Nucleotides, 1999, 18, 1477 – 1478
DOI: 10.1080/07328319908044758

29

Solid-phase synthesis: designer linkers for combinatorial chemistry

K Gordon and S Balasubramanian
J.Chem. Tech. Biotech., 1999, 74, 835 – 851
DOI: 10.1002/(SICI)1097-4660(199909)74:9<835::AID-JCTB130>3.0.CO;2-Z

28

Recent advances in solid-phase chemical methodologies

K Gordon and S Balasubramanian
Current Opinion in Drug Discovery and Development, 1999, 2, 342 – 349

27

Exploring a chemical encoding strategy for combinatorial synthesis using Friedels-Craft alkylation

R H Scott, C Barnes U Gerhard and S Balasubramanian
Chem. Commun., 1999, 1331-1332
DOI: 10.1039/A902489A

26

Studies on Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid Phase Synthesis

H B Lee and S Balasubramanian

J. Org. Chem., 1999, 64, 3454 – 3460; 1999, 64, 5728 (legend correction)
DOI: 10.1021/jo981987e

25

Inhibition of Human Telomerase by PNA- Cationic Peptide Conjugates

J G Harrison, C Frier, R Laurant, K D Raney and S Balasubramanian
Bioorg. Med. Chem. Lett., 1999, 9, 1273 – 1278
DOI: 10.1016/S0960-894X(99)00170-5

24

Progress in Chemical Encoding for Combinatorial Synthesis


C Barnes, R H Scott and S Balasubramanian
Recent Res. Devel. in Organic Chem., 1998, 2, 367 – 379
DOI: 10.1002/chin.199946279

23

Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates

J G Harrison and S Balasubramanian
Nucleic Acids Res., 1998, 26, 3136 – 3145
DOI: 10.1093/nar/26.13.3136

22

Optically Biased Diffusion of Single Molecules Studied by Confocal Fluorescence Microscopy


M A Osbourne, S Balasubramanian, W S Furey and D Klenerman

J. Phys. Chem. B, 1998, 102, 3160 – 3167
DOI: 10.1021/jp9715078

21

Use of Fluorescence Resonance Energy Transfer to Investigate the Conformation of DNA Substrates Bound to the Klenow Fragment

W S Furey, C M Joyce, M A Osbourne, D Klenerman, J A Peliska and S Balasubramanian
Biochemistry, 1998, 37, 2979 – 2990
DOI: 10.1021/bi9719758

20

A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine peptide Library


Y W Cheung, C Abell and S Balasubramanian
J. Am. Chem. Soc., 1997, 119, 9568 – 9569
DOI: 10.1021/ja971825k

19

Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids

M H Todd, S Balasubramanian and C Abell
Tetrahedron Lett., 1997, 38, 6781 – 6784
DOI: 10.1016/S0040-4039(97)01552-9

18

Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support

V Arumugam, A Routledge, C Abell and S Balasubramanian
Tetrahedron Lett., 1997, 38, 6473 – 6476
DOI: 10.1016/S0040-4039(97)01481-0

17

Properties of Fluorophores on Solid Phase Resins; Implications for Screening, Encoding and Reaction Monitoring

R H Scott and S Balasubramanian
Bioorg. Med. Chem. Lett., 1997, 7, 1567 – 1572
DOI: 10.1016/S0960-894X(97)00263-1

16

A Convenient Synthetic Route to Oligonucleotide Conjugates

J G Harrison and S Balasubramanian
Bioorg. Med. Chem. Lett., 1997, 7, 1041 – 1046
DOI: 10.1016/S0960-894X(97)00152-2

15

The Use of a Dithiane Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis

A Routledge, C Abell and S Balasubramanian

Tetrahedron Lett., 1997, 38, 1227 – 1230
DOI: 10.1016/S0040-4039(96)02478-1

14

An Investigation into Solid-Phase Radical Chemistry – Synthesis of Furan Rings


A Routledge, C Abell and S Balasubramanian

SynLett., 1997, 61 – 62
DOI: 10.1055/s-1997-704

13

Solid Phase Reductive Alkylation of Secondary Amines

N K Khan, V Arumugam and S Balasubramanian
Tetrahedron Lett., 1996, 37, 4819 – 4822
DOI: 10.1016/0040-4039(96)00945-8

12

Escherichia coli Chorismate Synthase Catalyses the Conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate


S Bornemann, M K Ramjee, S Balasubramanian, C Abell, J R Coggins, D J Lowe and R N F Thorneley
J. Biol. Chem., 1995, 270, 22811 – 22815
DOI: 10.1074/jbc.270.39.22811

11

The Mechanism of Metal Independent Hydroxylation by Chromobacterium violaceum Phenylalanine Hydroxylase

R T Carr, S Balasubramanian, P Hawkins and S J Benkovic

Biochemistry, 1995, 34, 7525 – 7532
DOI: 10.1021/bi00022a028

10

Escherichia coli Chorismate Synthase: A Deuterium Kinetic Isotope Effect Under Single Turnover and Steady State Conditions shows that a Flavin Intermediate forms before the C-(6proR)-H bond is cleaved

S Bornemann, S Balasubramanian, J R Coggins, C Abell, D J Lowe and R N F Thorneley

Biochem. J., 1995, 305, 707 – 710
DOI: 10.1042/bj3050707

9

Observation of a Secondary Tritium Isotope Effect in the Reaction Catalyzed by Neurospora Crassa Chorismate Synthase

S Balasubramanian, J R Coggins and C Abell
Biochemistry, 1995, 34, 341 – 348
DOI: 10.1021/bi00001a042

8

Recombinant HIV-1 Nucleocapsid Protein Accelerates HIV-1 Reverse Transcriptase Catalyzed DNA Strand Transfer Reactions and Modulates RNase H Activity


J A Peliska, S Balasubramanian, D P Giedroc and S J Benkovic
Biochemistry, 1994, 33, 13817 – 13823
DOI: 10.1021/bi00250a036

7

Identification of Metal Ligands in Cu(II) Inhibited Chromobacterium violaceum Phenylalanine Hydroxylase by Electron Spin Echo Envelope Modulation Analysis of Histidine to Serine Mutations


S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic

Biochemistry, 1994, 33, 8532 – 8537
DOI: 10.1021/bi00194a019

6

Studies on Escherichia coli Chorismate Synthase

S Borneman, M N Ramjee, D J Lowe, R N F Thorneley, J R Coggins, C Abell, S Balasubramanian, T R Hawkes, W W Nichols and G M Davies
Flavins and Flavoproteins, (Ed. K. Yagi) 843-846. Walter de Gruyer, Berlin, New York, 1994

5

Histidines 138 and 143 are Copper Binding Ligands in Chromobacterium violaceum Phenylalanine Hydroxylase

S Balasubramanian, R T Carr, C J Bender, J Peisach and S J Benkovic
Chemistry and Biology of Pteridines and Folates, Eds. J.E. Ayling, M.G. Nair, and C.M. Baugh, 1993, 67 – 71
DOI: 10.1007/978-1-4615-2960-6_13

4

Reaction of (6R)-6-F-EPSP with Recombinant Escherichia coli Chorismate Synthase Generates a Stable Flavin Mononucleotide Semiquinone Radical

M N Ramjee, S Balasubramanian, C Abell, J R Coggins, G M Davies, T R Hawkes, D J Lowe and R N F Thorneley
J. Am. Chem. Soc., 1992, 114, 3151 – 3153
DOI: 10.1021/ja00034a079

3

Inhibition of Chorismate Synthase by (6R)- and (6S)-6-Fluoro-5-enolpyruvylshikimate 3-Phosphate


S Balasubramanian, G M Davies, J R Coggins and C Abell
J. Am. Chem. Soc., 1991, 113, 8945 – 8946
DOI: 10.1021/ja00023a051

2

The Synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-Enolpyruvylshikimate 3-Phosphate

S Balasubramanian and C Abell
Tetrahedron Lett., 1991, 32, 963 – 966
DOI: 10.1016/S0040-4039(00)92131-2

1

Observation of an Isotope Effect in the Chorismate Synthase Reaction

S Balasubramanian, C Abell and J R Coggins

J. Am. Chem. Soc., 1990, 112, 8581-858
DOI: 10.1021/ja00179a052